The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants

scientific article

The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/ONC.2014.37
P932PMC publication ID4722800
P698PubMed publication ID24632620
P5875ResearchGate publication ID260841391

P50authorStefan M. PfisterQ39183179
Marc RemkeQ43153350
Marcel KoolQ90637389
Paul A NorthcottQ91826566
P2093author name stringJ Lee
M D Taylor
K Gandhi
R C Castellino
M C Buss
M J Schniederjan
P2860cites workTrafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalizationQ22010658
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loopQ24297633
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent mannerQ24336721
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsQ24527393
p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiationQ24596239
Molecular subgroups of medulloblastoma: the current consensusQ24615271
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyQ24651380
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.Q27851485
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23Q28218453
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activityQ28218469
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN lociQ28236937
Subgroup-specific structural variation across 1,000 medulloblastoma genomesQ28271811
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphataseQ28283888
Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastomaQ28284093
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcomeQ28298987
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancerQ28388006
Altered neural cell fates and medulloblastoma in mouse patched mutantsQ28588056
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutationsQ30040534
Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastomaQ30156001
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.Q33209208
Overexpressed TP73 induces apoptosis in medulloblastomaQ33290650
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological featuresQ33366431
Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosisQ33438165
Targeting p53 for Novel Anticancer TherapyQ33655329
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomasQ34167499
FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastomaQ34215755
G-protein-coupled receptors and cancer.Q34606002
G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4Q35166206
Clonal selection drives genetic divergence of metastatic medulloblastomaQ35784926
HDM2 promotes WIP1-mediated medulloblastoma growth.Q35845228
Functional genomics identifies drivers of medulloblastoma disseminationQ36296016
Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1DQ36326949
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroupsQ36460209
Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular VariablesQ36476670
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpointQ36841814
Medulloblastoma comprises four distinct molecular variantsQ36920479
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.Q37089440
Genetic variants and mutations of PPM1D control the response to DNA damage.Q37396919
A review on CXCR4/CXCL12 axis in oncology: no place to hide.Q38017493
Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91.Q39875833
Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.Q40263011
Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Surveillance Epidemiology and End ResultsQ40636357
c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in miceQ41589752
CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastomaQ41760694
RETRACTED ARTICLE: Localized synovial hypertrophy in the anteromedial compartment of the osteoarthritic kneeQ42425290
WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.Q42676343
SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells.Q43700208
Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patientsQ44608794
p53 expression predicts dismal outcome for medulloblastoma patients with metastatic diseaseQ44635070
Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trialQ45120061
Medulloblastoma: freedom from relapse longer than 8 years--a therapeutic cure?Q46648311
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodiesQ46853172
Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas.Q48506060
Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhoodQ48948841
PPM1D is a potential target for 17q gain in neuroblastomaQ52828743
Surveillance scanning of children with medulloblastoma.Q52883048
Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients.Q53286039
Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine.Q53322778
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.Q53346673
The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.Q53595739
Medulloblastoma: a potpourri of distinct entities.Q55462236
Adult medulloblastoma comprises three major molecular variants.Q55463035
Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.Q55468802
c-Myc promoter activation in medulloblastoma.Q55472620
Wip1 Phosphatase Modulates ATM-Dependent Signaling PathwaysQ61849111
The role of receptor kinases and arrestins in G protein-coupled receptor regulationQ74578170
Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survivalQ81325774
MedulloblastomaQ84749666
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectmedulloblastomaQ1333608
P304page(s)1126-1140
P577publication date2014-03-17
P1433published inOncogeneQ1568657
P1476titleThe WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants
P478volume34