G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4

scientific article

G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/BI2005202
P932PMC publication ID3156627
P698PubMed publication ID21728385
P5875ResearchGate publication ID51466518

P2093author name stringJeffrey L Benovic
Breann L Barker
P2860cites workHIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosisQ24298167
A predicted amphipathic helix mediates plasma membrane localization of GRK5Q24310352
Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signallingQ24321629
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5Q24336128
Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and traffickingQ24647176
Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signalingQ24647565
Mutational analysis of the hsp70-interacting protein HipQ24647965
Synucleins are a novel class of substrates for G protein-coupled receptor kinasesQ28138274
Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2Q28140208
Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2Q28140354
Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK familyQ28240861
Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5Q28251366
Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6Q28252224
Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression systemQ28263716
Regulation of receptor trafficking by GRKs and arrestinsQ28268248
Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variantsQ28278171
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2Q28299947
The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cellsQ28509420
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signalingQ30432989
The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transductionQ34016197
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.Q34064133
Regulation of G protein-coupled receptor kinasesQ34126348
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency diseaseQ34190328
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2Q35131741
The ins and outs of G protein-coupled receptor traffickingQ35183866
Involvement of chemokine receptors in organ-specific metastasisQ36455122
Trafficking of G protein-coupled receptorsQ36594595
Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytesQ36858613
Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.Q38308305
Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitizationQ38361904
G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channelQ40208895
G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeletonQ40432756
The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulinQ41032869
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamiliesQ41159622
The β-Adrenergic Receptor Kinase (GRK2) Is Regulated by PhospholipidsQ41296481
Binding and phosphorylation of tubulin by G protein-coupled receptor kinasesQ47761391
G protein-coupled receptor kinasesQ77366588
Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophagesQ80276238
P4510describes a project that usesImageQuantQ112270642
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
phosphorylationQ242736
P304page(s)6933-6941
P577publication date2011-07-12
P1433published inBiochemistryQ764876
P1476titleG protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4
P478volume50

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cites work (P2860)
Q29417144A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans
Q34218573A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization.
Q55508245A single amino acid substitution in CXCL12 confers functional selectivity at the beta-arrestin level.
Q52583829A variant of GRK5 is associated with the therapeutic efficacy of repaglinide in Chinese Han patients with type 2 diabetes mellitus.
Q34611859Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells
Q47740257G Protein-Coupled Receptor Kinases in the Inflammatory Response and Signaling.
Q37167895G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation
Q36006990G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition
Q42056965G-protein-coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in a polymicrobial sepsis model in mice.
Q26801467G-protein-coupled receptor kinases in inflammation and disease
Q37214389Genetic Determinants of Type 2 Diabetes in Asians
Q34755795Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.
Q39126530Mechanisms of Regulation of the Chemokine-Receptor Network.
Q34614326Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process
Q42323959Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues
Q27685147Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle
Q50285621The Role of G Protein-coupled Receptor Kinases in Cancer
Q36490004The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants
Q36218540The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions
Q34219369β-Arrestin1 and distinct CXCR4 structures are required for stromal derived factor-1 to downregulate CXCR4 cell-surface levels in neuroblastoma

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