Regulation of receptor trafficking by GRKs and arrestins

scientific article

Regulation of receptor trafficking by GRKs and arrestins is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1146/ANNUREV.PHYSIOL.69.022405.154712
P3181OpenCitations bibliographic resource ID663830
P698PubMed publication ID17037978

P2093author name stringJeffrey L Benovic
Shawn K Milano
Catherine A C Moore
P407language of work or nameEnglishQ1860
P304page(s)451-82
P577publication date2007-01-01
P1433published inAnnual Review of PhysiologyQ567364
P1476titleRegulation of receptor trafficking by GRKs and arrestins
P478volume69

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cites work (P2860)
Q3636820214-3-3ζ Protein regulates anterograde transport of the human κ-opioid receptor (hKOPR).
Q3573319617β-estradiol signaling and regulation of Sertoli cell function
Q33617270A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit
Q27936217A calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6.
Q39956855A homogeneous enzyme fragment complementation-based beta-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors
Q89532087A kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework
Q39103103A label-free optical biosensor with microfluidics identifies an intracellular signalling wave mediated through the β(2)-adrenergic receptor
Q89637920A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration
Q24300454A novel GRK2/HDAC6 interaction modulates cell spreading and motility
Q39603042A novel trafficking signal within the HLA-C cytoplasmic tail allows regulated expression upon differentiation of macrophages
Q38089182A perspective on more effective GPCR-targeted drug discovery efforts.
Q34506992A single lys residue on the first intracellular loop modulates the endoplasmic reticulum export and cell-surface expression of α2A-adrenergic receptor
Q89531733A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity
Q35954036A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export
Q34076241AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release
Q35632439ARF family G proteins and their regulators: roles in membrane transport, development and disease.
Q35837141ARRDC1 as a mediator of microvesicle budding
Q36003618Acute activation of β2-adrenergic receptor regulates focal adhesions through βArrestin2- and p115RhoGEF protein-mediated activation of RhoA.
Q35562523Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals.
Q42613667Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.
Q57023982Airway smooth muscle photorelaxation via opsin receptor activation
Q97681381Analyzing kinetic signaling data for G-protein-coupled receptors
Q35875489Anterograde trafficking of nascent α(2B)-adrenergic receptor: structural basis, roles of small GTPases
Q34043023Application of in utero electroporation of G-protein coupled receptor (GPCR) genes, for subcellular localization of hardly identifiable GPCR in mouse cerebral cortex
Q50496653Arf6 negatively controls the rapid recycling of the β2 adrenergic receptor.
Q36953762Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences
Q38831938Arrestin-2 and arrestin-3 differentially modulate locomotor responses and sensitization to amphetamine
Q33992591Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4
Q37336333Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2
Q41986106BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm Bombyx mori
Q37045440Beta-arrestin-mediated signaling in the heart
Q29616793Beta-arrestins and cell signaling
Q38214613Biased signaling of protease-activated receptors
Q24309529Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases
Q51547929C-terminal of human histamine H1 receptors regulates their agonist-induced clathrin-mediated internalization and G-protein signaling.
Q35106596CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association
Q39597237CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.
Q24318576CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum
Q41944437CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1α and ubiquitin
Q30541389CXCL12-induced monocyte-endothelial interactions promote lymphocyte transmigration across an in vitro blood-brain barrier
Q42082356Cannabinoid CB1 and CB2 Receptor Signaling and Bias
Q64058913Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
Q30487855Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway
Q40106332Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors
Q34762029Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions
Q37165951Characterization of relaxin receptor (RXFP1) desensitization and internalization in primary human decidual cells and RXFP1-transfected HEK293 cells
Q34416235Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular α₁-adrenergic receptor function
Q55235440Chemotactic Cues for NOTCH1-Dependent Leukemia.
Q42263287Chronic stress promotes lymphocyte reduction through TLR2 mediated PI3K signaling in a β-arrestin 2 dependent manner
Q37529047Class B β-arrestin2-dependent CCR5 signalosome retention with natural antibodies to CCR5.
Q64055252Concepts of GPCR-controlled navigation in the immune system
Q30557505Conformational biosensors reveal GPCR signalling from endosomes.
Q30485797Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis
Q34285721Cooperation Between the Septins and the Actomyosin Ring and Role of a Cell-Integrity Pathway During Cell Division in Fission Yeast
Q45194242Coordinate-based co-localization-mediated analysis of arrestin clustering upon stimulation of the C-C chemokine receptor 5 with RANTES/CCL5 analogues
Q37735949Custom-designed proteins as novel therapeutic tools? The case of arrestins
Q33374405Delayed internalization and lack of recycling in a beta2-adrenergic receptor fused to the G protein alpha-subunit
Q33685883Deletion of the distal COOH-terminus of the A2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling
Q57099294Desensitization of depolarization-mediated contractile pathways does not necessarily regulate receptor-mediated excitation-contraction coupling in longitudinal smooth muscle of guinea pig ileum
Q36463629Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor
Q33961384Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract
Q39077634Dexamethasone in the presence of desipramine enhances MAPK/ERK1/2 signaling possibly via its interference with β-arrestin
Q42522747Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptor
Q42428997Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation
Q35166797Differential expression of arrestins is a predictor of breast cancer progression and survival
Q42126128Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK
Q34787383Differential temporal and spatial regulation of somatostatin receptor phosphorylation and dephosphorylation
Q34551737Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis
Q42865771Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins.
Q28118801Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking
Q36887413Divergent modes for cargo-mediated control of clathrin-coated pit dynamics
Q35585071Dual mode of glucagon receptor internalization: role of PKCα, GRKs and β-arrestins
Q37670366Dynamic mass redistribution analysis of endogenous β-adrenergic receptor signaling in neonatal rat cardiac fibroblasts
Q34803218EFR3s are palmitoylated plasma membrane proteins that control responsiveness to G-protein-coupled receptors
Q34048283EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms
Q39436094Endocrinology and the brain: corticotropin-releasing hormone signaling
Q29616848Endocytosis and signalling: intertwining molecular networks
Q33931244Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals
Q26798878Evidence for the role of corticotropin-releasing factor in major depressive disorder
Q47163312Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.
Q27313090FYVE-dependent endosomal targeting of an arrestin-related protein in amoeba
Q38698390Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins.
Q27333875Filamin A-hinge region 1-EGFP: a novel tool for tracking the cellular functions of filamin A in real-time
Q37638132Fine-tuning of GPCR activity by receptor-interacting proteins
Q39300226Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.
Q36580782Formyl peptide receptor-mediated ERK1/2 activation occurs through G(i) and is not dependent on beta-arrestin1/2.
Q42117966Functional consequences of perturbed CXCL12 signal processing: analyses of immature hematopoiesis in GRK6-deficient mice
Q35881875G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro
Q51090373G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin.
Q36665235G Protein-coupled Receptor Biased Agonism
Q35838936G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression
Q54642775G protein-coupled receptor kinase (GRK)
Q37167895G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation
Q38307746G protein-coupled receptor kinase 2 moderates recruitment of THP-1 cells to the endothelium by limiting histamine-invoked Weibel-Palade body exocytosis.
Q28728953G protein-coupled receptor kinase 2, with β-arrestin 2, impairs insulin-induced Akt/endothelial nitric oxide synthase signaling in ob/ob mouse aorta
Q36006990G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition
Q35166206G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4
Q47069082G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans
Q33553460G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation
Q37200868G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.
Q38834292G protein-coupled receptor kinases as regulators of dopamine receptor functions
Q36914223G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction
Q35662226G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells
Q38018652G-protein coupled receptor resensitization-appreciating the balancing act of receptor function.
Q24298167G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis
Q37058647GPCR monomers and oligomers: it takes all kinds
Q37141950GPCR signaling along the endocytic pathway
Q28277702GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
Q47850354GRK2/β-arrestin mediates arginine vasopressin-induced cardiac fibroblast proliferation.
Q36652054GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance
Q46392966GRPR antagonist protects from drug-induced liver injury by impairing neutrophil chemotaxis and motility.
Q48389256GSK-3β Interacts with Dopamine D1 Receptor to Regulate Receptor Function: Implication for Prefrontal Cortical D1 Receptor Dysfunction in Schizophrenia.
Q37781424GSK-3β activity and hyperdopamine-dependent behaviors
Q37439970Green light to illuminate signal transduction events.
Q42687594Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation
Q37529530HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism
Q47394219Heterologous phosphorylation-induced formation of a stability lock permits regulation of inactive receptors by β-arrestins
Q35279688Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.
Q42032404Heterotrimeric G-protein signaling in Arabidopsis: Puzzling G-protein-coupled receptor
Q26269890High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex
Q26752632Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis
Q36412846Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization
Q42510638Identification and functional characterization of the pheromone biosynthesis activating neuropeptide receptor isoforms from Mamestra brassicae
Q37224229Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer
Q35000307Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor-positive breast cancers.
Q38758506Identification of human somatostatin receptor 2 domains involved in internalization and signaling in QGP-1 pancreatic neuroendocrine tumor cell line
Q41414211Identification of immune response-related genes and signalling pathways in spleen of Vibrio parahaemolyticus-infected Epinephelus fuscoguttatus (Forskal) by next-generation sequencing
Q92689354Identification of putative Type-I sex pheromone biosynthesis-related genes expressed in the female pheromone gland of Streltzoviella insularis
Q36320429Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM.
Q34659164Imaging ligand-dependent activation of CXCR7.
Q42082080Impaired feedback regulation of the receptor activity and the myofilament Ca2+ sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage
Q48170805Impaired striatum-dependent behavior in GASP-1-knock-out mice
Q33819256In search of analgesia: emerging roles of GPCRs in pain.
Q99629092Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction
Q36318886Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.
Q36303242Inferring the lifetime of endosomal protein complexes by fluorescence recovery after photobleaching
Q33991193Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3.
Q39898138Intracellular trafficking of the human oxytocin receptor: evidence of receptor recycling via a Rab4/Rab5 "short cycle".
Q47668309Investigating Internalization and Intracellular Trafficking of GPCRs: New Techniques and Real-Time Experimental Approaches
Q35921640Involvement of nuclear factor κB (NF-κB) signaling pathway in regulation of cardiac G protein-coupled receptor kinase 5 (GRK5) expression
Q37963358Keeping the balance between proliferation and differentiation: the primary cilium
Q37238856Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development
Q34105586Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease
Q24647565Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling
Q33650270Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors
Q35001258Ligand-dependent mechanisms of sst2A receptor trafficking: role of site-specific phosphorylation and receptor activation in the actions of biased somatostatin agonists
Q34438861Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail
Q35779987Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity
Q40621763Loss of β-arrestin1 expression predicts unfavorable prognosis for non-small cell lung cancer patients
Q34767650M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms
Q36446593MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors
Q38210121MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation
Q47303449Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling.
Q37305078Modeling of G-protein-coupled receptor signaling pathways
Q36553327Modulation of methuselah expression targeted to Drosophila insulin-producing cells extends life and enhances oxidative stress resistance.
Q33654876Molecular basis of impaired glycogen metabolism during ischemic stroke and hypoxia
Q41895362Molecular determinants of orexin receptor-arrestin-ubiquitin complex formation
Q37928310Molecular genetics of retinal degeneration: A Drosophila perspective
Q37360145Monomeric rhodopsin is the minimal functional unit required for arrestin binding
Q37551913Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis
Q34488901Multiple Scaffolding Functions of β-Arrestins in the Degradation of G Protein-coupled Receptor Kinase 2
Q40434620Muscarinic acetylcholine receptor-mediated tight junction opening is involved in epiphora in late phase of submandibular gland transplantation
Q27016049Muscle plasticity and β₂-adrenergic receptors: adaptive responses of β₂-adrenergic receptor expression to muscle hypertrophy and atrophy
Q37698155Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice
Q37369199Nanoconjugation prolongs endosomal signaling of the epidermal growth factor receptor and enhances apoptosis
Q24320318Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
Q41298460Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
Q37050877New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle.
Q39859981New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration
Q30010172Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.
Q39533158Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis
Q26747422Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious
Q24320039Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
Q98178368Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies
Q34268347Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer
Q35951881Phosphorylation of sst2 receptors in neuroendocrine tumors after octreotide treatment of patients
Q35580796Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress
Q36680544Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells
Q28304837Physiologic and cardiac roles of beta-arrestins
Q35617641Potent Anti-HIV Chemokine Analogs Direct Post-Endocytic Sorting of CCR5
Q33799795Prolyl hydroxylase 2: a novel regulator of β2 -adrenoceptor internalization
Q37135949Prostaglandin E2 affects T cell responses through modulation of CD46 expression
Q35791490Protein-protein interactions at the adrenergic receptors
Q54979675Quantitative Control of GPCR Organization and Signaling by Endocytosis in Epithelial Morphogenesis.
Q28472427Quantitative modeling of GRK-mediated beta2AR regulation
Q24302003Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi
Q33924469Rab8 interacts with distinct motifs in alpha2B- and beta2-adrenergic receptors and differentially modulates their transport
Q35972045Re-Evaluation of the PBAN Receptor Molecule: Characterization of PBANR Variants Expressed in the Pheromone Glands of Moths.
Q39412560Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell
Q38944155Region-specific roles of the corticotropin-releasing factor-urocortin system in stress.
Q36943320Regulated recycling of mutant CFTR is partially restored by pharmacological treatment
Q52319999Regulation of Clathrin-Mediated Endocytosis.
Q38521133Regulation of GPCR Trafficking by Ubiquitin
Q24294895Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent
Q35027563Regulation of Rho-GEF Rgf3 by the arrestin Art1 in fission yeast cytokinesis
Q37388772Regulation of nuclear factor κB (NF-κB) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5).
Q36701400Regulation of post-Golgi traffic of G protein-coupled receptors
Q35064562Regulation of protease-activated receptor signaling by post-translational modifications
Q35179117Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
Q37453900Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2
Q37726354Regulators of G protein signaling proteins as central components of G protein-coupled receptor signaling complexes
Q30844374Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions
Q35841335Rhodopsin management during the light-dark cycle of Anopheles gambiae mosquitoes
Q37178682Rich tapestry of G protein-coupled receptor signaling and regulatory mechanisms
Q48594442Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest
Q30475129Role of CRF receptor signaling in stress vulnerability, anxiety, and depression.
Q36763812Role of Ubiquitination in Endocytic Trafficking of G‐Protein‐Coupled Receptors
Q37129351Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease
Q38226347Role of phospholipase d in g-protein coupled receptor function
Q35841895Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors.
Q36197653Role of rhodopsin and arrestin phosphorylation in retinal degeneration of Drosophila
Q37329469Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation
Q37676928Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking
Q38050189Roles of proteolysis in regulation of GPCR function
Q41107029S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary
Q35091511S-nitrosylation-regulated GPCR signaling
Q50939912SAR study and conformational analysis of a series of novel peptide G protein-coupled receptor kinase 2 inhibitors.
Q24297153SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane
Q36731235Selective agonism in somatostatin receptor signaling and regulation
Q36932111Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation
Q33870369Signal transduction by protease-activated receptors
Q30445020Signaling by sensory receptors
Q37302221Signaling from endosomes: location makes a difference.
Q57359903Signaling on the endocytic pathway
Q43106575Site specificity of agonist and second messenger-activated kinases for somatostatin receptor subtype 2A (Sst2A) phosphorylation
Q30432989Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
Q26858975Small GTPase regulation of GPCR anterograde trafficking
Q36735740Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium
Q35216414Somatostatin receptor biology in neuroendocrine and pituitary tumours: part 1--molecular pathways
Q52341061Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.
Q28508089Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4
Q39152899Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells
Q48324782Split luciferase complementation assay for the analysis of G protein-coupled receptor ligand response in Saccharomyces cerevisiae.
Q27649357Structure of Vps26B and mapping of its interaction with the retromer protein complex
Q27657193Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking
Q37332439Subcellular trafficking of the TRH receptor: effect of phosphorylation
Q93372309Sustained Melanopsin Photoresponse Is Supported by Specific Roles of β-Arrestin 1 and 2 in Deactivation and Regeneration of Photopigment
Q24315160TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes
Q38186775Targeting cell surface trafficking of pain-facilitating receptors to treat chronic pain conditions
Q36230191Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development.
Q28571736Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control
Q38089142The A, B, Cs of G-protein-coupled receptor pharmacology in assay development for HTS.
Q37634891The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β2-adrenergic receptor recycling and ERK activation
Q39775078The GIT-PIX complexes regulate the chemotactic response of rat basophilic leukaemia cells
Q26765437The Ins and Outs of Anthrax Toxin
Q47107303The Role of Natural Antibodies to CC Chemokine Receptor 5 in HIV Infection
Q36562896The Role of chemokine receptor CXCR4 in breast cancer metastasis
Q27865233The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1
Q37236186The arrestin fold: variations on a theme
Q38928549The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling.
Q38313467The calcium sensing receptor: from calcium sensing to signaling
Q37356066The carboxy-terminal tail of human cytomegalovirus (HCMV) US28 regulates both chemokine-independent and chemokine-dependent signaling in HCMV-infected cells
Q39945961The carboxyl-terminal PDZ ligand motif of chemokine receptor CXCR2 modulates post-endocytic sorting and cellular chemotaxis
Q37768803The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets
Q52738410The complexities of G-protein-coupled receptor kinase function in Hedgehog signaling.
Q36944706The complications of promiscuity: endocannabinoid action and metabolism
Q24323133The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization
Q36000382The evolving impact of g protein-coupled receptor kinases in cardiac health and disease
Q30250314The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development
Q46965251The hydrophobic amino acid cluster at the cytoplasmic end of transmembrane helix III modulates the coupling of the β(1)-adrenergic receptor to G(s).
Q42781808The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility
Q24292828The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
Q47952666The neuro control of the ovarain cycle - a hypothesis
Q90913018The role of GPCRs in bone diseases and dysfunctions
Q33747115The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4
Q59807304Therapeutic Targets for Treatment of Heart Failure: Focus on GRKs and β-Arrestins Affecting βAR Signaling
Q40455623Tracking cell surface GABAB receptors using an alpha-bungarotoxin tag
Q37021523Trafficking of central opioid receptors and descending pain inhibition
Q36887422Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps
Q38521174Trafficking of β-Adrenergic Receptors: Implications in Intracellular Receptor Signaling
Q30544677Two tyrosine-based sorting signals in the Cx43 C-terminus cooperate to mediate gap junction endocytosis
Q36670706Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling
Q36228675Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family
Q39033646Ubiquitination and the Regulation of Membrane Proteins
Q36411260Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
Q39850663Ubiquitination of chemokine receptors
Q49960856Unique Roles of β-Arrestin in GPCR Trafficking Revealed by Photoinducible Dimerizers
Q35764696Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor
Q27008332Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches
Q26766480Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set
Q41535363Visualization of ligand-induced dopamine D2S and D2L receptor internalization by TIRF microscopy
Q37168887WHIM syndrome: congenital immune deficiency disease
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