Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process

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Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...857324G
P356DOI10.1371/JOURNAL.PONE.0057324
P932PMC publication ID3589474
P698PubMed publication ID23472081
P5875ResearchGate publication ID235886358

P50authorJulie BossuytQ57401334
Donald M. BersQ40664240
Erhe GaoQ38137327
P2093author name stringLinda Lee
Walter J Koch
Douglas G Tilley
Joseph E Rabinowitz
J Kurt Chuprun
Jonathan Hullmann
Jeffrey S Martini
Jessica I Gold
P2860cites workStructure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulationQ22007990
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A predicted amphipathic helix mediates plasma membrane localization of GRK5Q24310352
Protein kinase cascades in the regulation of cardiac hypertrophyQ24518494
Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine tQ69789172
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MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failureQ79922459
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Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactionsQ39408797
G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expressionQ39784124
G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequenceQ40418854
Structure and mechanism of the G protein-coupled receptor kinases.Q40774628
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heartQ40892894
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamiliesQ41159622
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription couplingQ41919774
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Characterization of lymphocyte beta 2-adrenoceptor signalling in patients with left ventricular volume overload diseaseQ42518961
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockadeQ42538793
Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone ratsQ44019905
Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trialQ44994661
Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II.Q45264881
Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5Q24561772
Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase DomainQ27666718
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophyQ28219383
Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failureQ28568934
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart developmentQ28592216
Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2Q28611497
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G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.Q33795250
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Regulation of G protein-coupled receptor kinasesQ34126348
Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic MechanismsQ34253155
Phosphorylation of G protein-coupled receptors: GPCR kinases in heart diseaseQ34302311
Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseasesQ34313936
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CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivoQ35159705
G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4Q35166206
Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failureQ35228115
Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelinQ35312534
G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progressionQ35838936
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.Q35951476
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failureQ36286936
Physiological roles of G protein-coupled receptor kinases and arrestinsQ36737680
Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytesQ36858613
The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alphaQ36976809
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failureQ37000342
Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communicationQ37118045
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Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling.Q37537689
G protein-coupled receptor kinases in normal and failing myocardiumQ37881660
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
P304page(s)e57324
P577publication date2013-03-05
P1433published inPLOS OneQ564954
P1476titleNuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process
P478volume8

Reverse relations

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