| scholarly article | Q13442814 |
| P50 | author | Isao Oishi | Q55277232 |
| P2093 | author name string | Yasuhiro Minami | |
| Hiroko Fujimoto | |||
| Naoko Kato | |||
| Akinori Yoda | |||
| Takeshi Kondo | |||
| Nobuyuki Onishi | |||
| Xiao Zhou Xu | |||
| Kyoko Toyoshima | |||
| P2860 | cites work | Linkage of ATM to cell cycle regulation by the Chk2 protein kinase | Q22008502 |
| A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase | Q22008669 | ||
| Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome | Q22011001 | ||
| Chk2 activates E2F-1 in response to DNA damage | Q24300634 | ||
| Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila | Q24304184 | ||
| PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2 | Q24313485 | ||
| The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation | Q43628901 | ||
| Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks | Q43773216 | ||
| Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. | Q44284890 | ||
| PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break | Q44384534 | ||
| Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis | Q44509795 | ||
| A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment. | Q47072183 | ||
| Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis | Q47072850 | ||
| Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway | Q48022280 | ||
| A kinase from fission yeast responsible for blocking mitosis in S phase | Q48074342 | ||
| Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner | Q24336721 | ||
| PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints | Q24527393 | ||
| Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways | Q24533297 | ||
| Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control | Q24537538 | ||
| p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation | Q24596239 | ||
| A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage | Q24651421 | ||
| Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro | Q24656275 | ||
| hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response | Q28139139 | ||
| Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway | Q28141324 | ||
| Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain | Q28207961 | ||
| Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23 | Q28218453 | ||
| Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity | Q28218469 | ||
| Substrate specificity of the human protein phosphatase 2Cdelta, Wip1 | Q28243258 | ||
| The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair | Q28278532 | ||
| Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase | Q28283888 | ||
| DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein | Q28577209 | ||
| Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions | Q29614216 | ||
| DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis | Q29614217 | ||
| Chk1 and Chk2 kinases in checkpoint control and cancer | Q29617706 | ||
| The structure and regulation of protein phosphatases | Q29618929 | ||
| The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast | Q29620732 | ||
| Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import. | Q33292501 | ||
| Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination | Q34011653 | ||
| Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response | Q34075834 | ||
| Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription | Q34149479 | ||
| Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner | Q34324643 | ||
| CHK2 kinase--a busy messenger. | Q34457165 | ||
| Molecular reactions of protein phosphatases--insights from structure and chemistry | Q34465999 | ||
| Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2. | Q35079512 | ||
| DNA damage tumor suppressor genes and genomic instability | Q35755997 | ||
| The Chk2 protein kinase | Q35848492 | ||
| Wip1-deficient mice are resistant to common cancer genes | Q35862684 | ||
| A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins | Q38295120 | ||
| Chk2 activation and phosphorylation-dependent oligomerization | Q39674829 | ||
| Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines. | Q40553780 | ||
| Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation | Q40696570 | ||
| P433 | issue | 34 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 16 | |
| P304 | page(s) | 24847-24862 | |
| P577 | publication date | 2006-06-23 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1 | |
| P478 | volume | 281 |
| Q33294239 | A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. |
| Q41844898 | A small molecular scaffold for selective inhibition of Wip1 phosphatase |
| Q38963051 | Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability. |
| Q46593571 | Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase |
| Q52687490 | Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain. |
| Q46299925 | Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions |
| Q36743535 | Emerging roles of nuclear protein phosphatases |
| Q37603053 | Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14(ARF)-MDM2-p53 axis. |
| Q33813999 | Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas |
| Q37396919 | Genetic variants and mutations of PPM1D control the response to DNA damage. |
| Q33952816 | Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures |
| Q35842531 | Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage |
| Q36403630 | Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum |
| Q39738661 | Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage |
| Q24595171 | Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol |
| Q36429985 | Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1). |
| Q41073169 | PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin |
| Q36108815 | PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. |
| Q36181526 | PPM1D regulates p21 expression via dephoshporylation at serine 123 |
| Q39930727 | PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression |
| Q34198570 | Phosphatases in the cellular response to DNA damage. |
| Q36429982 | Regulation of the Wip1 phosphatase and its effects on the stress response. |
| Q37788536 | Serine/threonine phosphatases in the DNA damage response and cancer |
| Q48451908 | Smaller protein, larger therapeutic potential: PPM1D as a new therapeutic target in brainstem glioma |
| Q35908249 | Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase |
| Q24658001 | Targeting protein serine/threonine phosphatases for drug development |
| Q24310746 | The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress |
| Q36490004 | The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants |
| Q24297633 | The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop |
| Q36617172 | The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways. |
| Q33720757 | WIP1 phosphatase as pharmacological target in cancer therapy. |
| Q38266298 | Wip1 phosphatase in breast cancer |
Search more.