Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

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Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas is …
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scholarly articleQ13442814

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P356DOI10.1007/S00401-012-0958-8
P932PMC publication ID3306778
P698PubMed publication ID22358457
P5875ResearchGate publication ID221855065

P50authorPeter LichterQ2076661
François DozQ56809901
David T. W. JonesQ58388511
Richard GilbertsonQ64746860
Franck BourdeautQ66360615
Michael D. TaylorQ88072573
Christine HaberlerQ88178484
André O von BuerenQ88766377
Andrey KorshunovQ89166780
Yoon-Jae ChoQ90317000
Stefan RutkowskiQ90355738
Marcel KoolQ90637389
Steven CliffordQ90928957
Paul A NorthcottQ91826566
Scott L PomeroyQ92805532
Antoinette Y N Schouten-van MeeterenQ114726801
Olivier DelattreQ30119391
Martin McCabeQ37835209
Jan KosterQ39051477
Stefan M. PfisterQ39183179
Marc RemkeQ43153350
Magnus L BäcklundQ55458949
Dannis G van VuurdenQ56613322
P2093author name stringDavid W Ellison
V Peter Collins
Torsten Pietsch
Maria Schlanstein
P2860cites workMolecular subgroups of medulloblastoma: the current consensusQ24615271
The 2007 WHO classification of tumours of the central nervous systemQ24685772
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN lociQ28236937
beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour CommitteeQ28279527
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcomeQ28298987
Subtypes of medulloblastoma have distinct developmental originsQ28300616
Altered neural cell fates and medulloblastoma in mouse patched mutantsQ28588056
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological featuresQ33366431
A flexible R package for nonnegative matrix factorizationQ33624159
FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastomaQ34215755
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutationsQ34248736
Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samplesQ35837393
Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinctQ35960250
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroupsQ36460209
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cellsQ36882529
Medulloblastoma comprises four distinct molecular variantsQ36920479
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastomaQ37002410
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastomaQ39679776
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterationsQ40339027
Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristicsQ43631246
Treatment of early childhood medulloblastoma by postoperative chemotherapy aloneQ46367739
Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratificationQ48194323
Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients.Q53286039
Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.Q55462417
Adult medulloblastoma comprises three major molecular variants.Q55463035
Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.Q55468802
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttranscriptomeQ252857
meta-analysisQ815382
medulloblastomaQ1333608
P304page(s)473-484
P577publication date2012-02-23
P1433published inActa NeuropathologicaQ343168
P1476titleMolecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
P478volume123

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Q39365632Proton Beam Therapy for Pediatric Brain Tumor
Q44872362Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Q33709483RITA displays anti-tumor activity in medulloblastomas independent of TP53 status
Q38194436RNA binding protein-mediated post-transcriptional gene regulation in medulloblastoma
Q98280890Radial shock waves prevent growth retardation caused by the clinically used drug vismodegib in ex vivo cultured bones
Q38537549Radiotherapy for adult medulloblastoma: Long term result from a single institution. A review of prognostic factors and why we do need a multi-institutional cooperative program
Q39449209RalA is overactivated in medulloblastoma
Q37312706Real-time PCR assay based on the differential expression of microRNAs and protein-coding genes for molecular classification of formalin-fixed paraffin embedded medulloblastomas
Q37636027Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis
Q53737190Refining medulloblastoma subgroups.
Q52095907Regulation of USP37 Expression by REST-Associated G9a-Dependent Histone Methylation.
Q30878032Relative cerebral blood volume from dynamic susceptibility contrast perfusion in the grading of pediatric primary brain tumors
Q38742012Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine
Q51230315Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4.
Q92154185Resolving medulloblastoma cellular architecture by single-cell genomics
Q38121136Rhabdoid tumors: clinical approaches and molecular targets for innovative therapy
Q41989047Risk factors for the prognosis of pediatric medulloblastoma: a retrospective analysis of 40 cases
Q36901551Risk stratification of childhood medulloblastoma in the molecular era: the current consensus
Q88737429Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial
Q43153279Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays
Q38268588Role of CXCL12 and CXCR4 in normal cerebellar development and medulloblastoma.
Q37256443Role of MYC in Medulloblastoma.
Q54782837Rubinstein-Taybi syndrome predisposing to non-WNT, non-SHH, group 3 medulloblastoma.
Q38509205SHH inhibitors for the treatment of medulloblastoma
Q47840177SNCA, a novel biomarker for Group 4 medulloblastomas, can inhibit tumor invasion and induce apoptosis.
Q47851151STIL balancing primary microcephaly and cancer
Q91780113Salvage Therapy for Childhood Medulloblastoma: A Single Center Experience
Q90003904Salvage therapy for progressive, treatment-refractory or recurrent pediatric medulloblastoma: a systematic review protocol
Q91933328Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes
Q35611341Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.
Q38645948Sexual dimorphism in glioma glycolysis underlies sex differences in survival
Q34117529Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males
Q36956174Signaling pathway and molecular subgroups of medulloblastoma
Q26827171Significance and therapeutic value of miRNAs in embryonal neural tumors
Q50744249Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma.
Q58795103Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks
Q36471378Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma
Q91452793Stalled developmental programs at the root of pediatric brain tumors
Q89207952Subfrontal recurrence after cerebellar medulloblastoma resection without local relapse: case-based update
Q36929844Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma
Q92663944Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma
Q57794783Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma
Q37316068TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
Q38404462Targeted approaches to childhood cancer: progress in drug discovery and development
Q36618268Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumors
Q38222028Targeted treatment for sonic hedgehog-dependent medulloblastoma.
Q57042397Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33
Q35894565Targeting brain tumor cAMP: the case for sex-specific therapeutics
Q35246513Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma
Q26777997Targeting the Hedgehog Pathway in Pediatric Medulloblastoma
Q42361001The 2016 World Health Organization Classification of tumours of the Central Nervous System: what the paediatric neuroradiologist needs to know
Q36753692The Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors as a Paradigm for Cross-Species Comparative Oncogenomics
Q38421001The Emerging Molecular Foundations of Pediatric Brain Tumors
Q57474469The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer
Q39662585The Neuroradiological Spectra of Adult and Pediatric Medulloblastoma Differ : Results from a Literature-based Meta-analysis
Q96304778The Non-coding Side of Medulloblastoma
Q35542600The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma.
Q89184115The Role of Advanced Brain Tumor Imaging in the Care of Patients with Central Nervous System Malignancies
Q36490004The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants
Q38112071The adolescent and young adult with cancer: state of the art--brain tumor
Q41470815The anti-neoplastic activity of Vandetanib against high-risk medulloblastoma variants is profoundly enhanced by additional PI3K inhibition
Q38206276The biologic era of childhood medulloblastoma and clues to novel therapies
Q38008153The clinical implications of medulloblastoma subgroups
Q96576668The clinical treatment and outcome of cerebellopontine angle medulloblastoma: a retrospective study of 15 cases
Q39438064The evolution of medulloblastoma therapy to personalized medicine
Q36334648The germline variants in DNA repair genes in pediatric medulloblastoma: a challenge for current therapeutic strategies
Q38703533The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis.
Q38231122The molecular landscape of pediatric brain tumors in the next-generation sequencing era.
Q33697463The prenatal origins of cancer
Q46155460The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival
Q38083796The role of chromatin remodeling in medulloblastoma.
Q38092920The role of microRNAs in medulloblastoma.
Q37033873The role of stem cells and progenitors in the genesis of medulloblastoma
Q36896072The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs).
Q26782159The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma
Q28070264The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors
Q48000346The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities
Q37261835Treatment Options for Medulloblastoma and CNS Primitive Neuroectodermal Tumor (PNET)
Q30764536Treatment developments and the unfolding of the quality of life discussion in childhood medulloblastoma: a review
Q47132607Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma
Q46117209Tumor-associated macrophages in SHH subgroup of medulloblastomas
Q92289585UAB30, A Novel Rexinoid Agonist, Decreases Stemness In Group 3 Medulloblastoma Human Cell Line Xenografts
Q36288376Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups
Q42647486Update on molecular and genetic alterations in adult medulloblastoma
Q90197653Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma
Q88766689Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma
Q27853187Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Q38164659Vismodegib: an inhibitor of the Hedgehog signaling pathway in the treatment of basal cell carcinoma
Q34979270WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma
Q38053857What underlies the diversity of brain tumors?
Q34249356Widespread contribution of Gdf7 lineage to cerebellar cell types and implications for hedgehog-driven medulloblastoma formation
Q38952766Wnt activation affects proliferation, invasiveness and radiosensitivity in medulloblastoma.
Q90266281Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer
Q28080016Young investigator challenge: Cytomorphologic analysis of cerebrospinal fluid in 70 pediatric patients with medulloblastoma and review of the literature focusing on novel diagnostic and prognostic tests
Q64100105c-Myc activation promotes cofilin-mediated F-actin cytoskeleton remodeling and telomere homeostasis as a response to oxidant-based DNA damage in medulloblastoma cells
Q38973879miR-106b is overexpressed in medulloblastomas and interacts directly with PTEN.
Q36685489miR-192 suppresses leptomeningeal dissemination of medulloblastoma by modulating cell proliferation and anchoring through the regulation of DHFR, integrins, and CD47
Q38673795p53 and Meduloblastoma
Q33908911β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.

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