The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer

scientific article published on 11 October 2018

The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/BIOM8040112
P932PMC publication ID6316532
P698PubMed publication ID30314361

P2093author name stringStefano Stifani
P2860cites workThe prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau proteinQ22010198
COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancerQ24308780
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta productionQ24309767
A Pin1/mutant p53 axis promotes aggressiveness in breast cancerQ24312083
Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Disease, and Models to Predict Disease RecurrenceQ26774502
Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteinsQ26825421
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Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcomeQ28266821
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functionsQ29547189
Cyclin-dependent kinases: engines, clocks, and microprocessorsQ29614786
Multidomain Peptidyl Prolyl cis/trans IsomerasesQ30316949
The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop.Q30318118
Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase.Q30658503
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Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma.Q55457248
Prolyl isomerase Pin1: a promoter of cancer and a target for therapyQ58695611
BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expressionQ64381021
Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1Q79423580
High Pin1 expression is associated with tumor progression in colorectal cancerQ79924753
Medulloblastoma: From Molecular Subgroups to Molecular Targeted TherapiesQ88330665
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Polo-like kinases and acute leukemiaQ90929187
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PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cellsQ34283602
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.Q34285636
Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-κB.Q34372855
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesisQ34411509
The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progressionQ34548253
Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma TumorigenesisQ34550706
The rs2233678 polymorphism in PIN1 promoter region reduced cancer risk: a meta-analysisQ34846983
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Prevalent overexpression of prolyl isomerase Pin1 in human cancersQ35097986
Cancer stem cells in glioblastomaQ35829972
Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α.Q35897505
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effectQ36437994
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroupsQ36460209
Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cellsQ36738071
Medulloblastoma comprises four distinct molecular variantsQ36920479
The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and diseaseQ36945537
Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in TumorigenesisQ36955828
Pin1-Nanog expression in human glioma is correlated with advanced tumor progressionQ37181702
Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression.Q37257716
Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiationQ37475499
Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesisQ37485770
Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cellsQ37604060
Regulation and function of pyruvate kinase M2 in cancerQ37631099
The clinical implications of medulloblastoma subgroupsQ38008153
Mitochondria: FKBP38 and mitochondrial degradationQ38198443
ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and RepairQ38225143
Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegenerationQ38240761
Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular diseaseQ38265843
Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationshipsQ38340277
Pin1: Intimate involvement with the regulatory protein kinase networks in the global phosphorylation landscapeQ38376214
Glioblastoma: pathology, molecular mechanisms and markersQ38460865
Sonic hedgehog patterning during cerebellar developmentQ38616153
Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesisQ38632886
Cyclophilin A Maintains Glioma-Initiating Cell Stemness by Regulating Wnt/β-catenin Signaling.Q38645254
Intertumoral Heterogeneity within Medulloblastoma SubgroupsQ38671456
Inhibition of CDK-mediated Smad3 phosphorylation reduces the Pin1-Smad3 interaction and aggressiveness of triple negative breast cancer cells.Q38692982
Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-viral TherapyQ38795155
The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug targetQ38852028
Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathwayQ38964993
The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial InfectionsQ39021153
PIN1 inhibits apoptosis in hepatocellular carcinoma through modulation of the antiapoptotic function of survivinQ39207945
Diverse structures, functions and uses of FK506 binding proteins.Q39399392
Medulloblastoma: experimental models and realityQ39446793
Cyclosporin A and sanglifehrin A enhance chemotherapeutic effect of cisplatin in C6 glioma cells.Q39732080
Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma.Q39744728
Enhancement of vascular endothelial growth factor-mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpressionQ39813847
The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastomaQ39814307
Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiformeQ41082755
Knockdown of Pin1 leads to reduced angiogenic potential and tumorigenicity in glioblastoma cellsQ42152253
The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer.Q44618217
Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cellsQ46665781
A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein DaxxQ46949438
Glycogen Synthase Kinases: Moonlighting Proteins with Theranostic Potential in CancerQ47224305
Structure and function of the human parvulins Pin1 and Par14/17.Q47640105
A metabolic function of FGFR3-TACC3 gene fusions in cancer.Q47660101
Dual Roles of Pin1 in Cancer Development and ProgressionQ47965344
Challenges and Recent Advances in Medulloblastoma TherapyQ48004874
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectbrain cancerQ9303627
P577publication date2018-10-11
P1433published inBiomoleculesQ23929963
P1476titleThe Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer
P478volume8

Reverse relations

cites work (P2860)
Q94550998Cancer and Alzheimer's disease inverse relationship: an age-associated diverging derailment of shared pathways
Q64243731Introduction to Peptidyl-Prolyl cis/trans Isomerase (PPIase) Series

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