Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development

scientific article published on 11 October 2012

Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1750-3639.2012.00631.X
P8608Fatcat IDrelease_lthxisxmkncg5neqrpjcik5rde
P698PubMed publication ID22966790

P50authorArie PerryQ37837647
Vijay RamaswamyQ43153342
Charles G EberhartQ87148391
Paul A NorthcottQ91826566
P2093author name stringMichael D Taylor
James M Olson
Sameer Agnihotri
Sidney E Croul
Adrian M Dubuc
Donya Aref
Connor J Moffatt
P2860cites workMolecular subgroups of medulloblastoma: the current consensusQ24615271
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcomeQ28298987
Subtypes of medulloblastoma have distinct developmental originsQ28300616
Cerebellum development and medulloblastomaQ28304753
Development and cancer of the cerebellumQ28305235
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiationQ28505942
DNA array analysis of the developing rat cerebellum: transforming growth factor-beta2 inhibits constitutively activated NF-kappaB in granule neuronsQ28575059
The polycomb group protein EZH2 is involved in progression of prostate cancerQ29614514
TM4 microarray software suiteQ29618829
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological featuresQ33366431
Central nervous system neuronal migrationQ33593457
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomasQ34167499
Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic featuresQ34866372
Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in miceQ34998146
Clonal selection drives genetic divergence of metastatic medulloblastomaQ35784926
Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samplesQ35837393
MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathwayQ35907425
Morphing into cancer: the role of developmental signaling pathways in brain tumor formationQ36205991
c-Myc expression and MEK1-induced Erk2 nuclear localization are required for TGF-beta induced epithelial-mesenchymal transition and invasion in prostate cancerQ36294128
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroupsQ36460209
Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma developmentQ36509989
Transforming growth factor-beta in cancer and metastasisQ36585129
Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neuronsQ36735270
Medulloblastoma comprises four distinct molecular variantsQ36920479
The origins of medulloblastoma subtypesQ37014819
Noncanonical TGF-β signaling during mammary tumorigenesisQ37044600
Role of TGF-β and the tumor microenvironment during mammary tumorigenesisQ37044604
The TGF-beta paradox in human cancer: an updateQ37261631
Molecular diagnostics of CNS embryonal tumorsQ37794829
Medulloblastomas: update on a heterogeneous diseaseQ37926454
Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC.Q39469388
MicroRNA-21 suppression impedes medulloblastoma cell migrationQ39503647
Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastomaQ39593013
FOXG1 dysregulation is a frequent event in medulloblastomaQ40128459
Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescenceQ41980817
Enhanced neurogenesis from neural progenitor cells with G1/S-phase cell cycle arrest is mediated by transforming growth factor beta1.Q46376497
Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expressionQ46507354
Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc.Q46939297
Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafishQ47074019
TGF beta 1 and TGF beta 2 are potential growth regulators for medulloblastomas, primitive neuroectodermal tumors, and ependymomas: evidence in support of an autocrine hypothesisQ48125390
Transient production of TGF-beta 2 by postnatal cerebellar neurons and its effect on neuroblast proliferationQ48129225
Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratificationQ48194323
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effectQ48249566
Transforming growth factor-beta 2 both stimulates and inhibits neurogenesis of rat cerebellar granule cells in cultureQ48888000
TGF-beta2 neutralization inhibits proliferation and activates apoptosis of cerebellar granule cell precurors in the developing cerebellumQ48945809
The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.Q53492300
Adult medulloblastoma comprises three major molecular variants.Q55463035
P433issue2
P921main subjectmedulloblastomaQ1333608
P304page(s)178-191
P577publication date2012-10-11
P1433published inBrain PathologyQ4955776
P1476titleCanonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development
P478volume23

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Q471166124SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma
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Q92563867The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma
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Q30581795Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer