FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts.

scientific article published on 2 May 2018

FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-018-25263-5
P932PMC publication ID5932040
P698PubMed publication ID29720672

P50authorJamie M AyeQ88548481
Gregory K FriedmanQ42170568
Laura L StafmanQ88548479
P2093author name stringElizabeth A Beierle
Blake P Moore
Elizabeth Mroczek-Musulman
Jerry E Stewart
Evan F Garner
Adele P Williams
P2860cites workNIH Image to ImageJ: 25 years of image analysisQ23319322
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Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancerQ27853204
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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcomeQ28298987
FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levelsQ28541065
FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse modelQ29248124
FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cellsQ31952928
FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cellsQ40140527
FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPaseQ40317574
FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylationQ40528059
Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatmentQ40644323
Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.Q40745321
Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosisQ40749272
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Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenograftsQ42809089
Fingolimod confers neuroprotection through activation of Rac1 after experimental germinal matrix hemorrhage in rat pupsQ46079105
Activation of Akt and Erk pathways in medulloblastomaQ48397343
FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway.Q54334399
Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genesQ74415871
CIP2A is Overexpressed in Non-Small Cell Lung Cancer and Correlates with Poor PrognosisQ34138056
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FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphomaQ34269804
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FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signalingQ34459845
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PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effectsQ35552005
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Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastomaQ35845241
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemiaQ35945171
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphomaQ36384629
Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex virusesQ36493813
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosisQ36602177
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastomaQ36655904
Medulloblastoma comprises four distinct molecular variantsQ36920479
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Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of StrokeQ37209163
Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenograftsQ38263942
Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cellsQ38622060
SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell lineQ38699543
Oncogenic Role of SET/I2PP2A for Gynecologic CancersQ38738002
FTY720-induced enhancement of autophagy protects cells from FTY720 cytotoxicity in colorectal cancerQ38785633
Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer.Q38869675
FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cellsQ38879206
Childhood medulloblastoma.Q38885202
Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancerQ38937332
FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune systemQ39114974
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer modelsQ39242149
Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutationQ39438493
FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells.Q39565401
FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.Q39645996
PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice.Q39699582
CIP2A expression is elevated in cervical cancerQ39757518
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmedulloblastomaQ1333608
xenograftQ64148587
P304page(s)6913
P577publication date2018-05-02
P1433published inScientific ReportsQ2261792
P1476titleFTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts
P478volume8

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cites work (P2860)
Q92476256Applications of patient-derived tumor xenograft models and tumor organoids
Q57062990Investigation of PP2A and Its Endogenous Inhibitors in Neuroblastoma Cell Survival and Tumor Growth
Q92489253Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration
Q101407729Therapeutic potential of Fingolimod in triple negative breast cancer preclinical models

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