scholarly article | Q13442814 |
review article | Q7318358 |
P50 | author | Hazel Rogers | Q57416591 |
Richard G Grundy | Q58068549 | ||
P2093 | author name string | Jasper Estranero | |
Keshni Gudka | |||
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Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS. | Q33716552 | ||
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma | Q33751426 | ||
A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. | Q33926416 | ||
Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease | Q33990951 | ||
Cross-species genomics matches driver mutations and cell compartments to model ependymoma | Q34031780 | ||
Temsirolimus in the treatment of relapsed or refractory mantle cell lymphoma | Q34129360 | ||
ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. | Q34153957 | ||
CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity | Q34157312 | ||
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas | Q34167499 | ||
Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas | Q34191508 | ||
Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group | Q34196216 | ||
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy | Q34240198 | ||
Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program. | Q34249719 | ||
Novel agents targeting the IGF-1R/PI3K pathway impair cell proliferation and survival in subsets of medulloblastoma and neuroblastoma | Q34442835 | ||
Phenotypic variations in NF1-associated low grade astrocytomas: possible role for increased mTOR activation in a subset | Q34467227 | ||
A prognostic analysis of pediatrics central nervous system small cell tumors: evaluation of EGFR family gene amplification and overexpression | Q34486255 | ||
Profiling pathway-specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid rhabdoid tumors (CNS ATRT): favorable activity of targeting EGFR- ErbB2 signaling with lapatinib | Q34572719 | ||
Childhood brain tumors | Q34573495 | ||
Initial testing (stage 1) of the investigational mTOR kinase inhibitor MLN0128 by the pediatric preclinical testing program | Q34592429 | ||
Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy | Q35085321 | ||
Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors | Q35112340 | ||
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PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting | Q35260766 | ||
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Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist | Q35718965 | ||
An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes. | Q35904519 | ||
PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma | Q36157714 | ||
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Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program. | Q36386881 | ||
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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas | Q36532504 | ||
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A new mutational AKTivation in the PI3K pathway | Q36907930 | ||
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas | Q37055286 | ||
The regulation and function of Class III PI3Ks: novel roles for Vps34. | Q37063618 | ||
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer | Q37187915 | ||
Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas | Q37238690 | ||
p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity | Q37312165 | ||
Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target | Q37312742 | ||
Perifosine: update on a novel Akt inhibitor. | Q37393008 | ||
Prevalence of subependymal giant cell tumors in patients with tuberous sclerosis and a review of the literature | Q37399421 | ||
Medulloblastomics: the end of the beginning | Q37469904 | ||
Regulation and cellular functions of class II phosphoinositide 3-kinases. | Q38002953 | ||
PI3K in cancer-stroma interactions: bad in seed and ugly in soil. | Q38124762 | ||
Subependymal giant cell astrocytomas in patients with tuberous sclerosis complex: considerations for surgical or pharmacotherapeutic intervention | Q38150748 | ||
Targeted therapy in pediatric low-grade glioma | Q38194055 | ||
Phase 1 study of dalotuzumab monotherapy and ridaforolimus-dalotuzumab combination therapy in paediatric patients with advanced solid tumours | Q38392521 | ||
EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines | Q38420153 | ||
Drugging PI3K in cancer: refining targets and therapeutic strategies | Q38539217 | ||
Tuberous sclerosis--A model for tumour growth | Q38713439 | ||
JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma | Q38783253 | ||
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary | Q38829244 | ||
Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus. | Q38905340 | ||
The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy | Q38919020 | ||
A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes | Q39047678 | ||
PI3K pathway activation provides a novel therapeutic target for pediatric ependymoma and is an independent marker of progression-free survival | Q39090163 | ||
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications | Q39196241 | ||
Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours | Q39306427 | ||
Phase I study of vinblastine and sirolimus in pediatric patients with recurrent or refractory solid tumors | Q39365297 | ||
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia | Q39722770 | ||
Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration. | Q39922005 | ||
P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | brain tumor | Q233309 |
targeted therapy | Q492646 | ||
phosphoinositide-3 kinase inhibitor | Q7187512 | ||
protein kinase inhibitors | Q7251487 | ||
P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
P304 | page(s) | 2083-2095 | |
P577 | publication date | 2016-12-02 | |
2017-01-10 | |||
P1433 | published in | Oncotarget | Q1573155 |
P1476 | title | The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors | |
P478 | volume | 8 |