Medulloblastoma: recurrence and metastasis

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Medulloblastoma: recurrence and metastasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2217/CNS.13.30
P932PMC publication ID6166489
P698PubMed publication ID25054581

P2093author name stringSidney Croul
Donya Aref
P2860cites workMutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndromeQ24336457
Dissecting the genomic complexity underlying medulloblastomaQ24621907
Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous systemQ28270384
Subgroup-specific structural variation across 1,000 medulloblastoma genomesQ28271811
beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour CommitteeQ28279527
Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastomaQ28284093
ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migrationQ28284396
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcomeQ28298987
Subtypes of medulloblastoma have distinct developmental originsQ28300616
Control of neuronal precursor proliferation in the cerebellum by Sonic HedgehogQ28586621
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutationsQ30040534
Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastomaQ30156001
SPARC mediates Src-induced disruption of actin cytoskeleton via inactivation of small GTPases Rho-Rac-Cdc42Q30423594
CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009.Q30447832
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological featuresQ33366431
Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study.Q33539849
Mutations in SUFU predispose to medulloblastomaQ34133729
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomasQ34167499
Children's Oncology Group's 2013 blueprint for research: central nervous system tumors.Q34285237
Inhibition of the MET Receptor Tyrosine Kinase as a Novel Therapeutic Strategy in MedulloblastomaQ34398276
The molecular basis of Turcot's syndromeQ34662365
Rapid diagnosis of medulloblastoma molecular subgroupsQ34764793
Physical mapping of chromosome 17p13.3 in the region of a putative tumor suppressor gene important in medulloblastomaQ43667669
N-myc and c-myc oncogenes amplification in medulloblastomas. Evidence of particularly aggressive behavior of a tumor with c-myc amplification.Q45118490
Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trialQ45120061
The treatment of medulloblastoma. Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisoneQ45121434
Treatment of early childhood medulloblastoma by postoperative chemotherapy aloneQ46367739
Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expressionQ46507354
Molecular analysis of the lissencephaly gene 1 (LIS-1) in medulloblastomasQ48063530
Structural chromosomal abnormalities in human medulloblastomaQ48125276
Chromosome abnormalities in pediatric brain tumorsQ48135652
Large-cell medulloblastomas. A distinct variant with highly aggressive behaviorQ48459892
Large cell/anaplastic medulloblastomas and medullomyoblastomas: clinicopathological and genetic featuresQ48805693
High-resolution deletion mapping of chromosome arm 17p in childhood primitive neuroectodermal tumors reveals a common chromosomal disruption within the Smith-Magenis region, an unstable region in chromosome band 17p11.2.Q48822376
Epidemiology of adult medulloblastomaQ50638609
Medulloblastoma. A report of 201 cases with emphasis on the relationship of histologic variants to survivalQ51120057
Role of Wnt pathway in medulloblastoma oncogenesis.Q52547248
MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma.Q53201641
Stratification of medulloblastoma on the basis of histopathological grading.Q53255752
Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients.Q53286039
Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas.Q53300055
An operative staging system and a megavoltage radiotherapeutic technic for cerebellar medulloblastomas.Q54427712
Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.Q55468802
Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.Q55469539
Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas.Q55473840
"Large cell/anaplastic" medulloblastomas: a Pediatric Oncology Group Study.Q55474949
Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.Q55476488
Sporadic medulloblastomas contain oncogenic beta-catenin mutations.Q55477948
Correlation between polysialic-neural cell adhesion molecule levels in CSF and medulloblastoma outcomes.Q55479479
Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II.Q55480515
Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute.Q55481382
Medulloblastoma: survey of factors possibly influencing the prognosis.Q55489984
Nuclear localization and mutation of beta-catenin in medulloblastomasQ73662960
Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic featuresQ34866372
Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomesQ34977375
Anaplasia and grading in medulloblastomas.Q35208292
APC mutations in sporadic medulloblastomasQ35745470
Clonal selection drives genetic divergence of metastatic medulloblastomaQ35784926
Correlation of loss of heterozygosity at chromosome 9q with histological subtype in medulloblastomasQ35796194
Novel mutations target distinct subgroups of medulloblastoma.Q36143877
Morphing into cancer: the role of developmental signaling pathways in brain tumor formationQ36205991
Functional genomics identifies drivers of medulloblastoma disseminationQ36296016
Review: In vivo models for defining molecular subtypes of the primitive neuroectodermal tumor genome: current challenges and solutionsQ36451030
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroupsQ36460209
Comparative genomic hybridization and histological variation in primitive neuroectodermal tumoursQ36620330
Medulloblastoma comprises four distinct molecular variantsQ36920479
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastomaQ37002410
An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET).Q37177897
Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastomaQ38340521
The use of gene expression analysis to gain insights into signaling mechanisms of metastatic medulloblastoma.Q38352855
ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma.Q38358939
MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology GroupQ38456964
Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastomaQ39382947
MicroRNA-21 suppression impedes medulloblastoma cell migrationQ39503647
Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.Q39627627
Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysisQ39828521
c-Met activation in medulloblastoma induces tissue factor expression and activity: effects on cell migration.Q39862140
The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration.Q39879515
The role of the membrane cytoskeleton cross-linker ezrin in medulloblastoma cellsQ39904552
An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastomaQ39910333
Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferationQ39939384
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterationsQ40339027
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic diseaseQ40781851
Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumorsQ40795419
Molecular analysis of childhood primitive neuroectodermal tumors defines markers associated with poor outcomeQ40851117
Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumoursQ41099186
Medulloblastoma. The identification of prognostic subgroups and implications for multimodality managementQ41449272
Genetics of pediatric central nervous system tumorsQ41667932
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449Q42031842
Sporadic medulloblastomas contain PTCH mutations.Q42434884
Basal cell carcinomas in mice overexpressing sonic hedgehogQ42437252
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.Q42439709
Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.Q42440473
A frequent activated smoothened mutation in sporadic basal cell carcinomasQ42467910
P433issue4
P921main subjectmedulloblastomaQ1333608
P304page(s)377-385
P577publication date2013-07-01
P1433published inCNS oncologyQ26842350
P1476titleMedulloblastoma: recurrence and metastasis
P478volume2