Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

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Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1048635299
P356DOI10.1007/S00401-014-1276-0
P932PMC publication ID4059991
P698PubMed publication ID24791927
P5875ResearchGate publication ID262050375

P50authorPeter LichterQ2076661
Gudrun FleischhackQ92107761
Carsten DachsbacherQ102839730
Kerstin KaulichQ114726762
Heyko SkladnyQ114726763
Guido ReifenbergerQ30004009
Stefan M. PfisterQ39183179
Volker HovestadtQ43153333
Marc RemkeQ43153350
David T. W. JonesQ58388511
Jörg FelsbergQ66360667
Michael D. TaylorQ88072573
André O von BuerenQ88766377
Andrey KorshunovQ89166780
Andreas FaldumQ90049005
Katja von HoffQ90355734
Stefan RutkowskiQ90355738
Marcel KoolQ90637389
Martin MynarekQ90928955
Tobias GoschzikQ90928960
Paul A NorthcottQ91826566
P2093author name stringTorsten Pietsch
Rene Schmidt
Friedrich Cremer
P2860cites workRelative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplificationQ24530153
Molecular subgroups of medulloblastoma: the current consensusQ24615271
Dissecting the genomic complexity underlying medulloblastomaQ24621907
The 2007 WHO classification of tumours of the central nervous systemQ24685772
Nonparametric Estimation from Incomplete ObservationsQ25938997
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibitionQ27852966
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN lociQ28236937
beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour CommitteeQ28279527
DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsiesQ28282708
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcomeQ28298987
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological featuresQ33366431
Mutations in SUFU predispose to medulloblastomaQ34133729
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomasQ34167499
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutationsQ34248736
Medulloblastoma variants: age-dependent occurrence and relation to Gorlin syndrome--a new clinical perspectiveQ34605276
Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II studyQ36025964
Medulloblastoma comprises four distinct molecular variantsQ36920479
Subgroup-specific prognostic implications of TP53 mutation in medulloblastomaQ36929844
Medulloblastomics: the end of the beginningQ37469904
Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91.Q39875833
Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomasQ40156627
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterationsQ40339027
Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumorsQ40795419
Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arraysQ43153279
Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trialQ45120061
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomasQ45345260
Treatment of early childhood medulloblastoma by postoperative chemotherapy aloneQ46367739
Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratificationQ48194323
TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.Q54402731
Adult medulloblastoma comprises three major molecular variants.Q55463035
Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.Q55468802
Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.Q55469539
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectmulticenter clinical trialQ6934595
P304page(s)137-149
P577publication date2014-05-04
P1433published inActa NeuropathologicaQ343168
P1476titlePrognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort
P478volume128

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cites work (P2860)
Q33665382A Retrospective Study of Progression-Free and Overall Survival in Pediatric Medulloblastoma Based on Molecular Subgroup Classification: A Single-Institution Experience
Q90843167A little piece of mind: best practices for brain tumor intraoperative consultation
Q48116800Advances in Genomics Explain Medulloblastoma Behavior at the Bedside.
Q58491122Brain Tumours
Q37688184CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways
Q38819030Characterization of MHC Class I and β-2-Microglobulin Expression in Pediatric Solid Malignancies to Guide Selection of Immune-Based Therapeutic Trials
Q48138393Clinical Application of Whole Genome Array Improves the Diagnosis of Pediatric Brain Tumors
Q39795085Clinical, Pathological, and Molecular Characterization of Infant Medulloblastomas Treated with Sequential High-Dose Chemotherapy
Q91719964DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas
Q52655770DNA methylation-based classification of central nervous system tumours.
Q50063187DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma
Q38836198Establishment of a novel human medulloblastoma cell line characterized by highly aggressive stem-like cells
Q55459405Extent of resection in medulloblastoma: time to reconsider?
Q36142459Genetic and molecular alterations across medulloblastoma subgroups
Q48361757Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas
Q92811055Human Medulloblastoma Cell Lines: Investigating on Cancer Stem Cell-Like Phenotype
Q38629781Imaging Biomarkers for Adult Medulloblastomas: Genetic Entities May Be Identified by Their MR Imaging Radiophenotype.
Q91596369Medulloblastoma
Q54954567Medulloblastoma in the Molecular Era.
Q36493799Medulloblastoma subgroup-specific outcomes in irradiated children: who are the true high-risk patients?
Q50089784Medulloblastoma with transitional features between Group 3 and Group 4 is associated with good prognosis.
Q38791824Medulloblastoma: Tumor Biology and Relevance to Treatment and Prognosis Paradigm
Q64079587Medulloblastoma: optimizing care with a multidisciplinary approach
Q50604253Medulloblastoma: selecting children for reduced treatment.
Q37573700Molecular Classification of Medulloblastoma
Q39181104Molecular stratification of medulloblastoma: comparison of histological and genetic methods to detect Wnt activated tumours
Q36367397Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy.
Q47827397Multicenter pilot study of radio-chemotherapy as first-line treatment for adults with medulloblastoma (NOA-07).
Q98191465Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma
Q37004219Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis
Q41989047Risk factors for the prognosis of pediatric medulloblastoma: a retrospective analysis of 40 cases
Q36901551Risk stratification of childhood medulloblastoma in the molecular era: the current consensus
Q91780113Salvage Therapy for Childhood Medulloblastoma: A Single Center Experience
Q41969132Spatial heterogeneity in medulloblastoma
Q52097904Synergistic anti-cancer effects of epigenetic drugs on medulloblastoma cells.
Q88800677The clinical importance of medulloblastoma extent of resection: a systematic review
Q37391485Update on the integrated histopathological and genetic classification of medulloblastoma - a practical diagnostic guideline

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