Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation.

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Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1084920101
P356DOI10.1038/SREP46366
P932PMC publication ID5394470
P698PubMed publication ID28417956

P50authorMarcel KoolQ90637389
Peter SiesjöQ55221651
Gabriel Gallo-OllerQ63979399
Julio Enríquez PérezQ87852977
Malin WickströmQ42609796
P2093author name stringAnna Darabi
Cecilia Krona
Edward Visse
John Inge Johnsen
Emma Sandén
Tomas J Ekström
Thale Kristin Olsen
Cecilia Dyberg
Atosa Estekizadeh
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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell linesQ29615823
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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological featuresQ33366431
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NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancerQ33655771
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A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivoQ34132933
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomasQ34167499
Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristicsQ43631246
Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterpartsQ43671177
Tumor-associated macrophages in SHH subgroup of medulloblastomasQ46117209
Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cellsQ46841906
Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenograftsQ47951778
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Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma.Q55466712
Tissue expression of IL16 in prostate cancer and its association with recurrence after radical prostatectomyQ57565129
Modulation of lymphocyte migration by human lymphokines. I. Identification and characterization of chemoattractant activity for lymphocytes from mitogen-stimulated mononuclear cellsQ70232420
Enhancer hijacking activates GFI1 family oncogenes in medulloblastomaQ34362028
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesisQ34411509
Higher susceptibility of NOD/LtSz-scid Il2rg (-/-) NSG mice to xenotransplanted lung cancer cell linesQ34415301
Patient-specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ.Q34554842
Medulloblastoma subgroups remain stable across primary and metastatic compartmentsQ35099027
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Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells.Q35696355
COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subsetQ35818767
A standardized and reproducible protocol for serum-free monolayer culturing of primary paediatric brain tumours to be utilized for therapeutic assaysQ35860191
Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastomaQ35914511
MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-propertiesQ35925281
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Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.Q36134167
Novel mutations target distinct subgroups of medulloblastoma.Q36143877
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancerQ36228506
Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiformeQ36413742
Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responsesQ36591942
Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trialsQ36622291
Origin of the vasculature supporting growth of primary patient tumor xenograftsQ36863454
Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma.Q37040617
Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targetsQ37152015
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Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular nicheQ37433709
Cytogenetic prognostication within medulloblastoma subgroupsQ37627692
Collaborating with the enemy: function of macrophages in the development of neoplastic disease.Q38098161
Anti-angiogenic therapy in pediatric brain tumors: an effective strategy?Q38156302
Macrophage polarization in pathologyQ38554081
Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cellsQ38935879
COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models.Q38981326
Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomasQ39023964
Intratumoral COX-2 inhibition enhances GM-CSF immunotherapy against established mouse GL261 brain tumors.Q39062141
Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophagesQ39225975
Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinomaQ40428404
Karyotypic complexity of the NCI-60 drug-screening panel.Q40604171
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmedulloblastomaQ1333608
P304page(s)46366
P577publication date2017-04-18
P1433published inScientific ReportsQ2261792
P1476titleEstablishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation
P478volume7

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cites work (P2860)
Q92326554Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth
Q39446793Medulloblastoma: experimental models and reality
Q93039110Modeling medulloblastoma in vivo and with human cerebellar organoids
Q92862783Patient-Derived Orthotopic Xenograft Models of Pediatric Brain Tumors: In a Mature Phase or Still in Its Infancy?
Q42362521Preclinical Modeling and Therapeutic Avenues for Cancer Metastasis to the Central Nervous System
Q92705351Preclinical Models of Craniospinal Irradiation for Medulloblastoma
Q63976777Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation

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