Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma

scientific article

Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.CANLET.2014.02.017
P932PMC publication ID4141892
P698PubMed publication ID24569090

P50authorTimothy GershonQ42874066
P2093author name stringKatherine Tech
Mohanish Deshmukh
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
Dissecting the genomic complexity underlying medulloblastomaQ24621907
Links between metabolism and cancerQ24626229
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesQ24632807
Pyruvate kinase M2 is a phosphotyrosine-binding proteinQ27650067
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesisQ27671695
N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiationQ28207748
Subgroup-specific structural variation across 1,000 medulloblastoma genomesQ28271811
Control of neuronal precursor proliferation in the cerebellum by Sonic HedgehogQ28586621
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growthQ29547680
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesisQ29615683
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomasQ34167499
Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells.Q34342590
Malonyl-CoA: the regulator of fatty acid synthesis and oxidationQ34352236
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.Q34377342
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.Q35213694
Minireview: malonyl CoA, AMP-activated protein kinase, and adiposityQ35538672
Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastomaQ35837389
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroupsQ36460209
Childhood tumors of the nervous system as disorders of normal developmentQ36651332
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cellsQ36950291
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastomaQ37002410
MYC, metabolism, cell growth, and tumorigenesis.Q37040243
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activityQ37082118
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancerQ37120167
Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastomaQ37196742
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathwayQ37249645
Role of MYC in Medulloblastoma.Q37256443
Myc's broad reachQ37299032
Reflecting on 25 years with MYC.Q37333643
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapyQ37437194
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cellsQ37692621
IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectivesQ38052534
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiformeQ39606772
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growthQ39773538
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterationsQ40339027
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomasQ40497319
Cancer-associated IDH1 mutations produce 2-hydroxyglutarateQ41926372
Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastomaQ42167075
c-Myc and cancer metabolismQ42351696
Evidence that haploinsufficiency of Ptch leads to medulloblastoma in miceQ42485741
Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum.Q42919775
[18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastomaQ45169857
Demonstration of diffuse leptomeningeal metastasis in a treated case of medulloblastoma with F-18 FDG PET/CT.Q45925422
Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.Q48921989
Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.Q55476488
The lipogenesis pathway as a cancer targetQ84499304
P433issue2 Pt A
P407language of work or nameEnglishQ1860
P921main subjectcerebellumQ130983
medulloblastomaQ1333608
neurogenesisQ1456827
P304page(s)268-72
P577publication date2015-01-28
P1433published inCancer LettersQ326372
P1476titleAdaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma
P478volume356

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cites work (P2860)
Q41716968Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth
Q26770345Energy metabolism in neurodevelopment and medulloblastoma
Q47557123Long non-coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR-106a-5p/E2F3 axis.
Q44872362Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Q54977032Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice.
Q47161374TAp73 is a marker of glutamine addiction in medulloblastoma
Q100954531The critical roles of lncRNAs in the pathogenesis of melanoma
Q38737928Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice

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