Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells

scientific article published on 18 June 2013

Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CLIM.2013.06.005
P932PMC publication ID3809126
P698PubMed publication ID23891738

P50authorShahab AsgharzadehQ55458999
P2093author name stringXiuhua Gao
Nabil Ahmed
Jie Wei
Liping Song
Vita S Brawley
Daofeng Liu
Nathan Robison
Ashley Margol
Leonid S Metelitsa
Gengwen Tian
P2860cites workMolecular subgroups of medulloblastoma: the current consensusQ24615271
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Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptorQ27681807
Subgroup-specific structural variation across 1,000 medulloblastoma genomesQ28271811
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcomeQ28298987
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutationsQ30040534
Defective NKT cell activation by CD1d+ TRAMP prostate tumor cells is corrected by interleukin-12 with α-galactosylceramide.Q33622444
Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvantQ33628422
Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironmentQ33925291
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomasQ34167499
Establishment of a human medulloblastoma cell line and its heterotransplantation into nude miceQ34564601
Differential antitumor immunity mediated by NKT cell subsets in vivoQ34603019
The unconventional lifestyle of NKT cellsQ34770393
Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signalsQ35622939
Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-mycQ35818710
A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myelomaQ36370927
Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2Q36399484
Harnessing human CD1d restricted T cells for tumor immunity: progress and challengesQ37388427
The tumor biology and molecular characteristics of medulloblastoma identifying prognostic factors associated with survival outcomes and prognosis.Q37884837
Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profileQ38028930
Medulloblastomas expressing IL13Ralpha2 are targets for IL13-zetakine+ cytolytic T cells.Q40070837
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterationsQ40339027
Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastomaQ40376124
CD1d expression on B-precursor acute lymphoblastic leukemia subsets with poor prognosis.Q40451359
Autologous natural killer cell therapy for human recurrent malignant glioma.Q40531550
Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cellsQ40781889
Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cellsQ44452165
Regression of experimental medulloblastoma following transfer of HER2-specific T cellsQ45868854
Distinct homeostatic requirements of CD4+ and CD4- subsets of Valpha24-invariant natural killer T cells in humansQ46718817
Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell-mediated expansionQ47935150
Distinct roles for sphingolipids and glycosphingolipids at different stages of neuronal developmentQ48347333
Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.Q48439090
Loss of IFN-gamma production by invariant NK T cells in advanced cancer.Q52934636
Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.Q55469539
c-Myc promoter activation in medulloblastoma.Q55472620
Antigen-specific regulation of CD1 expression in humansQ74169467
Impaired proliferative response of V alpha 24 NKT cells from cancer patients against alpha-galactosylceramideQ74261475
P433issue1
P921main subjectmedulloblastomaQ1333608
immunotherapyQ1427096
P304page(s)55-64
P577publication date2013-06-18
P1433published inClinical ImmunologyQ15752921
P1476titleMedulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells
P478volume149

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