Poly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription

scientific article published on 2 April 2007

Poly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1044870856
P356DOI10.1038/SJ.ONC.1210434
P698PubMed publication ID17404575
P5875ResearchGate publication ID6416520

P50authorSimon D WagnerQ37830432
P2093author name stringH E Ambrose
V Papadopoulou
R W Beswick
P2860cites workSTAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomasQ24295903
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phaseQ24300180
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiationQ24305562
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damageQ24522502
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
Poly(ADP-ribose) polymerase is a B-MYB coactivatorQ28140372
The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator functionQ28190711
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediatorQ28243358
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphomaQ28256118
A B-cell-specific DNA recombination complexQ28274822
Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcriptionQ28291892
A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expressionQ28345011
Transcription. Gene expression needs a break to unwind before carrying onQ79774694
Specific binding of poly(ADP-ribose) polymerase-1 to cruciform hairpinsQ81643488
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathwayQ28579105
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammationQ28584806
Control of inflammation, cytokine expression, and germinal center formation by BCL-6Q28585541
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functionsQ29617672
Poly(ADP-ribose): novel functions for an old moleculeQ29617735
Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ationQ30640821
A peptide aptamer to antagonize BCL-6 function.Q33228615
The PARP superfamilyQ34335821
Role of poly(ADP-ribose) formation in DNA repairQ34359946
Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomasQ34380954
The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT.Q34480893
PARP goes transcriptionQ35155777
Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factorQ35203930
The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activityQ35204751
Poly(ADP-ribosyl)ated chromatin domains: access grantedQ35667074
PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse developmentQ35848522
Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structureQ36297600
Two new isotype-specific switching activities detected for Ig class switchingQ36709872
Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1.Q37149860
BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressorQ37477121
Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.Q37626496
Analysis of nucleotide sequence-dependent DNA binding of poly(ADP-ribose) polymerase in a purified systemQ38346297
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.Q40263593
Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequencesQ40414748
Analysis of multiple genomic sequence alignments: a web resource, online tools, and lessons learned from analysis of mammalian SCL loci.Q40497945
ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.Q40627341
Acetylation inactivates the transcriptional repressor BCL6.Q40694067
Sequence-specific binding of poly(ADP-ribose) polymerase-1 to the human T cell leukemia virus type-I tax responsive elementQ40728894
TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell lineQ40982321
Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocationQ41127074
Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell lineQ41729284
Transcription. Puffing with PARP.Q44288761
NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.Q45193551
Regulation of poly(ADP-ribose) polymerase-1 by DNA structure-specific bindingQ45287574
BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma.Q45345453
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.Q52085890
Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.Q52548831
Identification of negative regulatory regions within the first exon and intron of the BCL6 gene.Q53404877
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic HypermutationQ57198273
(ADP-ribose)n participates in DNA excision repairQ59086284
Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphomaQ72529454
Transcriptional repression by binding of poly(ADP-ribose) polymerase to promoter sequencesQ77088821
P433issue42
P407language of work or nameEnglishQ1860
P304page(s)6244-6252
P577publication date2007-04-02
P1433published inOncogeneQ1568657
P1476titlePoly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription
P478volume26

Reverse relations

cites work (P2860)
Q36637370AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6.
Q40324816An Infectious Disease-Associated Il12b Polymorphism Regulates IL-12/23 p40 Transcription Involving Poly(ADP-Ribose) Polymerase 1.
Q47148667Antidepressant-Like Actions of Inhibitors of Poly(ADP-Ribose) Polymerase in Rodent Models
Q38089268Beyond DNA repair, the immunological role of PARP-1 and its siblings.
Q39281377C-terminal binding protein and poly(ADP)ribose polymerase 1 contribute to repression of the p21(waf1/cip1) promoter
Q35961020Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade
Q38325685Deciphering the insights of poly(ADP-ribosylation) in tumor progression.
Q39063397Flow signaling and atherosclerosis
Q33649584Functional Aspects of PARP1 in DNA Repair and Transcription
Q89659830Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies
Q27304386Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
Q45365306Novel poly (ADP-ribose) polymerase 1 binding motif in hepatitis B virus core promoter impairs DNA damage repair
Q37022423PARP activation promotes nuclear AID accumulation in lymphoma cells
Q98386293PARP inhibition and immune modulation: scientific rationale and perspectives for the treatment of gynecologic cancers
Q34651839PARP-1 and YY1 are important novel regulators of CXCL12 gene transcription in rat pancreatic beta cells
Q92383717PARP-1 deregulation in multiple sclerosis
Q37021548Poly(ADP-ribose) polymerase-1 down-regulates BRCA2 expression through the BRCA2 promoter
Q39217821Regulation of HFE expression by poly(ADP-ribose) polymerase-1 (PARP1) through an inverted repeat DNA sequence in the distal promoter
Q37699389Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells
Q38047690Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes
Q37036322STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.
Q33638395The BRCT domain of PARP-1 is required for immunoglobulin gene conversion
Q27666697The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger
Q36132464The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.
Q37508170The Sound of Silence: RNAi in Poly (ADP-Ribose) Research
Q35636016Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1.2. Association with Sodium-Dependent Bile Acid Transport
Q36842905Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation