The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function

scientific article (publication date: 7 December 2001)

The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M106528200
P698PubMed publication ID11590148

P2093author name stringS Hasan
M Covic
M O Hottiger
R Imhof
P O Hassa
P2860cites workNF-kappaB is activated and promotes cell death in focal cerebral ischemiaQ48220270
Nuclear factor-kappaB/Rel proteins: a point of convergence of signalling pathways relevant in neuronal function and dysfunctionQ48298914
Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching.Q54558116
Tankyrase, a poly(ADP-ribose) polymerase at human telomeresQ22008022
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymeraseQ22010521
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1.Q24522478
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signallingQ28139111
CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10Q28140452
Poly(ADP-ribose) polymerase-1 in the nervous systemQ28144839
Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivatorsQ28299369
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functionsQ29617672
Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathwayQ33592325
Poly (ADP-ribose) polymerase, nitric oxide and cell deathQ33633084
Role of general and gene-specific cofactors in the regulation of eukaryotic transcriptionQ33671382
Identification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax proteinQ33798511
Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient miceQ33891214
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?Q33944812
Inhibition of nuclear receptor signalling by poly(ADP-ribose) polymeraseQ33957685
NF-kappaB in neuronal plasticity and neurodegenerative disordersQ34131754
The world according to PARP.Q34179346
Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation.Q34340925
DNA repair defect in poly(ADP-ribose) polymerase-deficient cell linesQ34668455
Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetesQ35065308
Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosisQ35606094
Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitroQ36035454
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonismQ36369850
An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activationQ36666995
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.Q37738852
PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation.Q39727130
PARP is important for genomic stability but dispensable in apoptosisQ40442742
Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymeraseQ40896649
The human general co-factorsQ40929080
Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivatorQ41133317
Nitric oxide synthase: role in the genesis of vascular diseaseQ41360752
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicityQ41488356
Rel/NF-kappa B and I kappa B proteins: an overviewQ41595423
Achieving transcriptional specificity with NF-kappa B.Q41756452
Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300.Q42140547
P433issue49
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)45588-97
P577publication date2001-12-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function
P478volume276

Reverse relations

cites work (P2860)
Q3573855917β estradiol regulates adhesion molecule expression in mesangial cells during glomerulonephritis
Q447601643-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice
Q356835743. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia.
Q27657009A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Q35963779ARTD1 Suppresses Interleukin 6 Expression by Repressing MLL1-Dependent Histone H3 Trimethylation.
Q34045036Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation
Q34520738Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury
Q41553016Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets
Q36371540Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage
Q34129764Activation of poly(ADP-ribose) polymerase-1 delays wound healing by regulating keratinocyte migration and production of inflammatory mediators
Q42422374Activator-induced spread of poly(ADP-ribose) polymerase promotes nucleosome loss at Hsp70.
Q36069553Airway blood flow changes and airway obstruction following lung injury
Q42445357Angiotensin II promotes poly(ADP-ribosyl)ation of c-Jun/c-Fos in cardiac fibroblasts
Q28512283Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression
Q52372449Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach.
Q38089268Beyond DNA repair, the immunological role of PARP-1 and its siblings.
Q34652977Caspases in cell survival, proliferation and differentiation.
Q36450945Caspases leave the beaten track: caspase-mediated activation of NF-kappaB.
Q41012711Charon Mediates Immune Deficiency-Driven PARP-1-Dependent Immune Responses in Drosophila
Q28216747Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway
Q40137373Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription
Q38337980Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells.
Q44839291Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia
Q36913813Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes
Q37995692DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out.
Q44403217Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock.
Q80805109Differential expression in lupus-associated IL-10 promoter single-nucleotide polymorphisms is mediated by poly(ADP-ribose) polymerase-1
Q38346928Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
Q90512417Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide
Q40550641Dual regulation of AP-2alpha transcriptional activation by poly(ADP-ribose) polymerase-1
Q48146722Dual role of intrauterine immune challenge on neonatal and adult brain vulnerability to hypoxia-ischemia
Q36252549Engagement of Components of DNA-Break Repair Complex and NFκB in Hsp70A1A Transcription Upregulation by Heat Shock
Q28590100Essential role of poly(ADP-ribosyl)ation in cocaine action
Q35543779Fine Tuning the Transcriptional Regulation of the CXCL1 Chemokine
Q33649584Functional Aspects of PARP1 in DNA Repair and Transcription
Q33553364Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells
Q28207148Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing
Q33267541Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression
Q46217674In vivo regulation of the chicken cardiac troponin T gene promoter in zebrafish embryos.
Q36001244Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
Q41880369Inhibition of poly(adenosine diphosphate-ribose) polymerase attenuates ventilator-induced lung injury
Q34355908Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation.
Q42161912Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats
Q33920534Interaction of Sindbis virus non-structural protein 3 with poly(ADP-ribose) polymerase 1 in neuronal cells
Q39908141Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance
Q47109838Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo
Q36858872Life and death in peripheral T cells
Q39536409Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction.
Q36410673Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice
Q43479307Mechanical stretch induces angiotensinogen expression through PARP1 activation in kidney proximal tubular cells.
Q40608483Modulation of the activation of extracellular signal-regulated kinase (ERK) and the production of inflammatory mediators by ADP-ribosylation inhibitors
Q59138338Molecular Mechanisms of H. pylori-Induced DNA Double-Strand Breaks
Q37235363Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
Q111440848Molecular response to PARP1 inhibition in ovarian cancer cells as determined by mass spectrometry based proteomics
Q92256639Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases
Q38677373NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699.
Q28477156NF-κB potentiates caspase independent hydrogen peroxide induced cell death
Q36348582NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1
Q34042969New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases
Q36118418New opportunities in chemosensitization and radiosensitization: modulating the DNA-damage response
Q46933091Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene
Q37574176Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice
Q38510909Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites
Q24669960Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?
Q37373701Oxidative stress and accelerated vascular aging: implications for cigarette smoking
Q46564526Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications.
Q37334922PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.
Q39957001PARP mediates structural alterations in diabetic cardiomyopathy
Q24300180PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
Q34030005PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro
Q34421470PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells
Q35004641PARP-1 modulates amyloid beta peptide-induced neuronal damage
Q42107975PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?
Q53830448PARP-1: a new player in the asthma field?
Q34491906PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B.
Q35679521PARP1 activation/expression modulates regional-specific neuronal and glial responses to seizure in a hemodynamic-independent manner
Q64059806PARP1 is a versatile factor in the regulation of mRNA stability and decay
Q26858894Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation
Q46799848Poly (ADP) ribose synthetase inhibition in alveolar macrophages undergoing hypoxia and reoxygenation
Q37111639Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation
Q90645966Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity
Q41820940Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review.
Q99551282Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation
Q38134049Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications
Q37693027Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
Q28185088Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes
Q35192798Poly(ADP-ribose) polymerase 1-sirtuin 1 functional interplay regulates LPS-mediated high mobility group box 1 secretion
Q37773040Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications
Q42441367Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses.
Q33578933Poly(ADP-ribose) polymerase-1 and its cleavage products differentially modulate cellular protection through NF-kappaB-dependent signaling
Q34017468Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia
Q34023297Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation
Q40501267Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat.positive transcription elongation factor b (p-TEFb) complex
Q39076617Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription
Q40181345Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.
Q36161842Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury.
Q40019330Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.
Q38155805Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response
Q35858661Poly(ADP-ribosyl)ation inhibitors: promising drug candidates for a wide variety of pathophysiologic conditions
Q40150418Poly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription
Q40637491Recombinant IFN-alpha2b treatment activates poly (ADPR) polymerase-1 (PARP-1) in KB cancer cells
Q35570762Regulation of Chromatin Structure and Gene Activity by Poly(ADP-Ribose) Polymerases
Q39217821Regulation of HFE expression by poly(ADP-ribose) polymerase-1 (PARP1) through an inverted repeat DNA sequence in the distal promoter
Q36204365Regulation of chromatin structure by poly(ADP-ribosyl)ation
Q33303916Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1
Q35874520Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase
Q44936746Role of PARP on iNOS pathway during endotoxin-induced acute lung injury
Q35074264Role of PARP under stress conditions: cell death or protection?
Q51016986Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy.
Q37008658Role of Txk, a member of the Tec family of tyrosine kinases, in immune-inflammatory diseases
Q44225537Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents
Q38047690Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes
Q44519296Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment
Q34638102Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line
Q40458807Synergistic inhibition of PARP-1 and NF-κB signaling downregulates immune response against recombinant AAV2 vectors during hepatic gene therapy.
Q92012927The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers
Q24629787The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1
Q39447003The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study
Q33376830The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation
Q38346240The septic shock-associated IL-10 -1082 A > G polymorphism mediates allele-specific transcription via poly(ADP-Ribose) polymerase 1 in macrophages engulfing apoptotic cells
Q37070511Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells
Q36884763Transcriptional Reprogramming and Resistance to Colonic Mucosal Injury in Poly(ADP-ribose) Polymerase 1 (PARP1)-deficient Mice
Q47827497Transcriptome-wide identification of the RNA-binding landscape of the chromatin-associated protein PARP1 reveals functions in RNA biogenesis.
Q88204103Trastuzumab-Resistant HER2+ Breast Cancer Cells Retain Sensitivity to Poly (ADP-Ribose) Polymerase (PARP) Inhibition
Q33799832Trypanosoma cruzi induces the reactive oxygen species-PARP-1-RelA pathway for up-regulation of cytokine expression in cardiomyocytes
Q34185821Tumor necrosis factor signaling.
Q34348370Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death
Q24337273Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells
Q34605890ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A.
Q40671288gamma-Irradiation-induced DNA damage enhances NO production via NF-kappaB activation in RAW264.7 cells