Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers

scientific article

Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.186.9.1547
P932PMC publication ID2199107
P698PubMed publication ID9348312
P5875ResearchGate publication ID13881501

P2093author name stringJ Sklar
F C Kuo
P2860cites workCharacterization of a mammalian homolog of the Escherichia coli MutY mismatch repair proteinQ24309547
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesisQ24318724
Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidineQ27932229
Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damageQ28114912
Differential display of eukaryotic messenger RNA by means of the polymerase chain reactionQ28131789
T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell deathQ28237366
Biology of germinal centers in lymphoid tissueQ28247064
Opposing roles of CD95 (Fas/APO-1) and CD40 in the death and rescue of human low density tonsillar B cellsQ28289647
Rad51 expression and localization in B cells carrying out class switch recombinationQ28508346
Germinal centersQ29616234
The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)Q29619959
An immunoglobulin mutator that targets G.C base pairsQ33584295
Modeling and optimization of populations subject to time-dependent mutationQ33958359
Hypothesis: somatic hypermutation by gene conversion via the error prone DNA----RNA----DNA information loopQ34398630
The B-cell development in tonsillar lymphoid follicles.Q34420183
Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversityQ34487675
In situ studies of the antigen-driven somatic hypermutation of immunoglobulin genesQ35380869
Selection of B cell clones and memory B cellsQ36137566
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spotsQ36172034
Antibody diversity: somatic hypermutation of rearranged VH genesQ36587415
Presence of human cellular protein(s) that specifically binds and cleaves 8-hydroxyguanine containing DNA.Q38349097
Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?Q38622353
The role of somatic hypermutation in the generation of antibody diversityQ38637313
Somatic hypermutationQ40404787
Somatic hypermutation: how many mechanisms diversify V region sequences?Q40410605
Targeting and regulation of immunoglobulin gene somatic hypermutation and isotype switch recombinationQ40527478
Cyclic re-entry of germinal center B cells and the efficiency of affinity maturationQ40858324
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sectionsQ40874465
Somatic hypermutation of immunoglobulin genesQ40955728
The mechanism of somatic hypermutation studied with transgenic and transfected target genesQ41062365
Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.Q41151304
Intraclonal generation of antibody mutants in germinal centresQ41172275
The physiology of germinal centersQ41255669
cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotidesQ41289899
Assessment of genotoxicity and mutagenicity of 1,2-dioxetanes in human cells using a plasmid shuttle vectorQ41371256
Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. Anti-Ig down-regulates Fas expression of CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosisQ42636387
Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamilyQ42638192
8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene: effects of sequence contexts on mutation spectraQ42828820
Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemiaQ46240932
A DNA repair abnormality specific for rearranged immunoglobulin variable genes in germinal center B cellsQ48066611
Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutationQ48292078
Antigen receptor-induced apoptosis of human germinal center B cells is targeted to a centrocytic subset.Q52044185
Generation of memory B cells and plasma cells in vitro.Q52053106
Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cellsQ53460260
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.Q54608320
Deficiencies in sight with the candidate gene approachQ59012185
Death of germinal center B cells without DNA fragmentationQ63965625
Somatic hypermutation of immunoglobulin genes is linked to transcription initiationQ70934062
Frequent expression of shared idiotypes in mantle cell lymphoma and extranodal small lymphocytic/non-mantle cell diffuse small cleaved lymphomaQ71519357
The germinal center reactionQ71782131
Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switchingQ71874702
The role of IL-10 in human B cell activation, proliferation, and differentiationQ72169049
Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cellsQ72913128
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectlymph nodeQ170758
B-cellQ188930
P304page(s)1547-1556
P577publication date1997-11-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleAugmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers
P478volume186

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cites work (P2860)
Q24651327Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
Q33770245Altered spectra of hypermutation in DNA repair-deficient mice
Q33928805Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.
Q33601035Base excision repair of 8-hydroxyguanine protects DNA from endogenous oxidative stress
Q40448068Cadmium down-regulates human OGG1 through suppression of Sp1 activity.
Q27860529Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Q46628437Expression of human 8-oxoguanine DNA glycosylase (hOGG1) in follicular lymphoma
Q47933820Germinal centers: form and function.
Q28505917Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
Q91657262Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing
Q64245890Mitochondrial DNA Integrity: Role in Health and Disease
Q30661985Molecular definition of the germinal centre stage of B-cell differentiation
Q38232000Oxidative DNA damage in disease--insights gained from base excision repair glycosylase-deficient mouse models
Q27640521Product-assisted catalysis in base-excision DNA repair
Q36972316Regulation of DNA glycosylases and their role in limiting disease
Q39200289Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics
Q28585021Severe attenuation of the B cell immune response in Msh2-deficient mice
Q33545735Somatic hypermutation and the three R's: repair, replication and recombination
Q34181353Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells
Q44468594Spontaneous increase of plasma-like cells with high GANP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice
Q35132482Structural and mechanistic studies on repair of 8-oxoguanine in mammalian cells.
Q27621681Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
Q38310719Substrate specificity and reaction mechanism of murine 8-oxoguanine-DNA glycosylase
Q33701467The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine
Q33818404The molecular and cellular origins of Hodgkin's disease
Q36400909The role of DNA repair in somatic hypermutation of immunoglobulin genes
Q38518565Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment.

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