| review article | Q7318358 |
| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1989Sci...244.1152F |
| P356 | DOI | 10.1126/SCIENCE.2658060 |
| P8608 | Fatcat ID | release_hld3j44qbnaq3ly3zpgsmkg4eq |
| P698 | PubMed publication ID | 2658060 |
| P2093 | author name string | Scharff MD | |
| Laskov R | |||
| French DL | |||
| P433 | issue | 4909 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | antibody | Q79460 |
| P1104 | number of pages | 6 | |
| P304 | page(s) | 1152-1157 | |
| P577 | publication date | 1989-06-01 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | The role of somatic hypermutation in the generation of antibody diversity | |
| P478 | volume | 244 |
| Q36878057 | 18 Antibody catalysis of concerted, carboncarbon bond-forming reactions |
| Q41264930 | A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro |
| Q48081204 | A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation |
| Q43619464 | A role of the third complementarity-determining region in the affinity maturation of an antibody. |
| Q40387464 | A speculative view of immune recognition |
| Q34505084 | A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene. |
| Q36231577 | Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism |
| Q33901961 | Analysis of human antitopoisomerase-I idiotypes |
| Q71118179 | Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes |
| Q36352010 | Analysis of somatic mutations in kappa transgenes |
| Q100750475 | Antibodies exhibit multiple paratope states influencing VH-VL domain orientations |
| Q33259491 | Antibody binding loop insertions as diversity elements |
| Q40912749 | Antibody engineering using Escherichia coli as host |
| Q34516546 | Antibody repertoires in infants and adults: effects of T-independent and T-dependent immunizations |
| Q39228846 | Antibody-based therapies for emerging infectious diseases |
| Q63247605 | Antibody-mediated effects against Cryptococcus neoformans: evidence for interdependency and collaboration between humoral and cellular immunity |
| Q35209481 | Are follicular dendritic cells really good for nothing? |
| Q36380783 | Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers |
| Q36380439 | B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes |
| Q36699314 | Binding and Multiple Hydrolytic Sites in Epitopes Recognized by Catalytic Anti-Peptide Antibodies |
| Q36354162 | Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene |
| Q36341119 | Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation |
| Q37120876 | Clonal evolution of a follicular lymphoma: evidence for antigen selection |
| Q38334354 | Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response |
| Q71868769 | Comparison of the immunoglobulin heavy-chain complementarity determining region-3 structure among the DNA sequences and the mu- and gamma-transcripts in human B-lineage cells |
| Q36336978 | Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study |
| Q35764445 | Comprehensive mapping of functional epitopes on dengue virus glycoprotein E DIII for binding to broadly neutralizing antibodies 4E11 and 4E5A by phage display |
| Q41195165 | Cryptococcus neoformans: paradigm for the role of antibody immunity against fungi? |
| Q34963864 | DNA sequences at immunoglobulin switch region recombination sites |
| Q36363581 | Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2. |
| Q35851102 | Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines |
| Q34599248 | Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity |
| Q34594726 | Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection |
| Q37698476 | Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. |
| Q35228379 | Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence |
| Q35754463 | Establishment of a novel B cell clonality analysis using single-strand conformation polymorphism of immunoglobulin light chain messenger signals |
| Q36327441 | Exploring Human Antimicrobial Antibody Responses on a Single B Cell Level |
| Q41064129 | Exploring the functional robustness of an enzyme by in vitro evolution |
| Q34283674 | Freeze-substitution: origins and applications |
| Q40696086 | Generating the antibody repertoire in rabbit. |
| Q31057169 | Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen |
| Q33896641 | Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen |
| Q36231063 | Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response |
| Q35030955 | Genetic diversity of the human immunoglobulin heavy chain VH region |
| Q36730922 | High expression of a 3'----5' exonuclease activity is specific to B lymphocytes |
| Q27676139 | High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells |
| Q36722950 | Homologous recombination in hybridoma cells: dependence on time and fragment length |
| Q38028575 | Hormonal support of lacrimal function, primary lacrimal deficiency, autoimmunity, and peripheral tolerance in the lacrimal gland |
| Q47113886 | How B-Cell Receptor Repertoire Sequencing Can Be Enriched with Structural Antibody Data. |
| Q42150981 | Idiotypic analysis of human anti-topoisomerase I autoantibodies. |
| Q45859104 | Immunoglobulin VH and VK genes of the BALB/c anti-foot-and-mouth disease virus (01) VP1 response: Cloning, characterization and transgenic mice |
| Q31131763 | Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes |
| Q35598710 | Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations |
| Q34114760 | Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line |
| Q38675619 | Immunologic and pharmacologic concepts of monoclonal antibodies. |
| Q38924824 | Immunotherapeutic strategies for sexually transmitted viral infections: HIV, HSV and HPV. |
| Q44348483 | Impact of molecular biology on our understanding of non-Hodgkin lymphoma |
| Q36362440 | In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells |
| Q41949877 | In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. |
| Q24672839 | In vitro evolution of single-chain antibodies using mRNA display |
| Q67685694 | Induction of nitrite production in mouse spleen cells by immunization |
| Q59057608 | Induction of self-tolerance in mature peripheral B lymphocytes |
| Q40301017 | Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium |
| Q48004003 | Inherent properties of somatic hypermutation as revealed by human non-productive VH6 immunoglobulin rearrangements |
| Q41172275 | Intraclonal generation of antibody mutants in germinal centres |
| Q47923096 | Junctional amino acids determine the maturation pathway of an antibody. |
| Q98771873 | Local and Global Rigidification Upon Antibody Affinity Maturation |
| Q46066569 | Low-affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten |
| Q52443852 | Maturation of the humoral immune response as an optimization problem |
| Q33958359 | Modeling and optimization of populations subject to time-dependent mutation |
| Q72095706 | Modeling study of antibody combining sites to (alpha 1-6)dextrans. Predictions of the conformational contribution of VL-CDR3 and J kappa segments to groove-type combining sites |
| Q34225507 | Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases |
| Q35296982 | Molecular biomarkers for the diagnosis of primary vitreoretinal lymphoma |
| Q34974782 | Molecular characterization of the cervical and systemic B-cell repertoire: Unique, yet overlapping, immune compartments of an HIV-1 resistant individual |
| Q36361541 | Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization |
| Q36881701 | Molecular cloning and characterization of desacetoxyvindoline-4-hydroxylase, a 2-oxoglutarate dependent-dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus (L.) G. Don. |
| Q34331092 | Molecular pathology of primary intraocular lymphoma |
| Q33966586 | Multiple vaccine-elicited nonneutralizing antienvelope antibody activities contribute to protective efficacy by reducing both acute and chronic viremia following simian/human immunodeficiency virus SHIV89.6P challenge in rhesus macaques |
| Q34504886 | Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break |
| Q37525213 | Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes |
| Q41768898 | Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity |
| Q41135996 | Natural catalytic antibodies |
| Q40429013 | New insights into V(D)J recombination and its role in the evolution of the immune system |
| Q41568249 | Nucleotide sequence analysis of CDR3 elements of a panel of anti-peptide monoclonal antibodies recognizing parathyroid hormone-related protein. |
| Q33565771 | Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases |
| Q35906761 | POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function |
| Q37868736 | Pathogenic anti-DNA antibodies in SLE: idiotypic families and genetic origins |
| Q56806045 | Pattern generation in molecular evolution: Exploitation of the variation in RNA landscapes |
| Q60303604 | Plant-derived chimeric antibodies inhibit the invasion of human fibroblasts by |
| Q36229896 | Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes |
| Q52992155 | Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection. |
| Q36364342 | Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell |
| Q33860729 | Protein evolution on partially correlated landscapes |
| Q42947038 | Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice |
| Q70769984 | Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with |
| Q74139589 | Role of BCR affinity in T cell dependent antibody responses in vivo |
| Q36771498 | Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells. |
| Q68217193 | Sequences of variable regions of a monoclonal antibody specific to the thyroid hormone, triiodo-L-thyronine |
| Q37156660 | Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplification |
| Q51070881 | Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic. |
| Q34412591 | Small Molecule Mimetics of an HIV-1 gp41 Fusion Intermediate as Vaccine Leads |
| Q34516540 | Somatic hypermutation in human B cell subsets |
| Q36361238 | Somatic hypermutation of an immunoglobulin mu heavy chain transgene |
| Q36369454 | Somatic hypermutation shapes the antibody repertoire of memory B cells in humans |
| Q35554322 | Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome |
| Q48945509 | Somatic mutations of synaptic cadherin (CNR family) transcripts in the nervous system |
| Q30328260 | Steered molecular dynamics investigations of protein function. |
| Q27678252 | Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape |
| Q41522864 | Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection. |
| Q40390039 | Structural implications of somatic mutations during the immune response to 2-phenyloxazolone |
| Q40626080 | The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement |
| Q35572435 | The LRF transcription factor regulates mature B cell development and the germinal center response in mice |
| Q59133073 | The Lupus-Associated Fcγ Receptor IIb-I232T Polymorphism Results in Impairment in the Negative Selection of Low-Affinity Germinal Center B Cells Via c-Abl in Mice |
| Q41329806 | The Somatic Hypermutation Activity of a Follicular Lymphoma Links to Large Insertions and Deletions of Immunoglobulin Genes |
| Q42852725 | The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl)acetyl antibody |
| Q67276602 | The biological equilibrium of base pairs |
| Q59023613 | The centre of hypermutation |
| Q36923517 | The contribution of non-MHC genes to susceptibility to autoimmune diseases |
| Q37717095 | The molecular biology of B-cell lymphoma: clinicopathologic implications |
| Q36230201 | The mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies |
| Q41817392 | The promotion of V region hypermutation |
| Q56891639 | Unrestricted usage of immunoglobulin heavy chain genes in B cells infiltrating the wall of atherosclerotic abdominal aortic aneurysms |
| Q41489024 | VH and V kappa segment structure of anti-insulin IgG autoantibodies in patients with insulin-dependent diabetes mellitus. Evidence for somatic selection. |
| Q41544908 | What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants? |
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