Altered spectra of hypermutation in DNA repair-deficient mice

scientific article

Altered spectra of hypermutation in DNA repair-deficient mice is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1098/RSTB.2000.0742
P932PMC publication ID1087685
P698PubMed publication ID11205330
P5875ResearchGate publication ID12126538

P2093author name stringGearhart PJ
Winter DB
P2860cites workAccumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damageQ24651327
Somatic hypermutation introduces insertions and deletions into immunoglobulin V genesQ24652779
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing overQ28282791
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancerQ28294774
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair proteinQ28505917
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targetingQ28506440
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation processQ28507129
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient miceQ28507519
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution patternQ28510640
Meiotic pachytene arrest in MLH1-deficient miceQ28510650
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modificationsQ28586687
Female embryonic lethality in mice nullizygous for both Msh2 and p53Q28587400
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair proteinQ28588513
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2Q28910215
A plethora of lesion-replicating DNA polymerasesQ33732359
Patterns of somatic mutations in immunoglobulin variable genesQ33952719
Multiple ATM-dependent pathways: an explanation for pleiotropyQ34388494
Which DNA polymerases are used for DNA-repair in eukaryotes?Q34422388
Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.Q35795316
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J geneQ36354162
B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genesQ36380439
Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centersQ36380783
Antibody diversity: somatic hypermutation of rearranged VH genesQ36587415
Clusters of point mutations are found exclusively around rearranged antibody variable genesQ36593569
High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A geneQ36694651
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosisQ38293261
Life and death in germinal centers (redux).Q40983825
Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune responseQ41232426
Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instabilityQ41467421
Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cellsQ42637489
mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversificationQ48397569
Somatic mutation of immunoglobulin light-chain variable-region genesQ48409137
Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanismQ48409267
Somatic mutation and the maturation of immune response to 2-phenyl oxazoloneQ58019387
Origin of Antibody VariationQ59057486
Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D)Q71163077
Mutator phenotype in Msh2-deficient murine embryonic fibroblastsQ73677771
The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genesQ73864520
Differential expression of DNA polymerase epsilon in resting and activated B lymphocytes is consistent with an in vivo role in replication and not repairQ73920002
P433issue1405
P407language of work or nameEnglishQ1860
P921main subjectsomatic hypermutation of immunoglobulin genesQ14911681
delta DNA polymerase complexQ21117979
P1104number of pages7
P304page(s)5-11
P577publication date2001-01-01
P1433published inPhilosophical Transactions of the Royal Society BQ2153239
P1476titleAltered spectra of hypermutation in DNA repair-deficient mice
P478volume356

Reverse relations

cites work (P2860)
Q34770418AID and mismatch repair in antibody diversification
Q36540495Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases
Q34994580Immunological disorders and DNA repair
Q36052347Inferring somatic mutation rates using the stop-enhanced green fluorescent protein mouse
Q40412801Somatic hypermutation and mismatch repair in non-B cells
Q34516540Somatic hypermutation in human B cell subsets

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