UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.

scientific article published on August 1999

UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1999PNAS...96.8919T
P356DOI10.1073/PNAS.96.16.8919
P932PMC publication ID17708
P698PubMed publication ID10430871
P5875ResearchGate publication ID12868625

P2093author name stringM O'Donnell
R Woodgate
X Shen
E G Frank
M F Goodman
M Tang
P2860cites workDeoxycytidyl transferase activity of yeast REV1 proteinQ27931173
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, PoletaQ27935465
The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanismQ27938714
RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis.Q33559613
UmuD mutagenesis protein of Escherichia coli: overproduction, purification, and cleavage by RecA.Q33559649
RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activationQ33559704
Efficient translesion replication in the absence of Escherichia coli Umu proteins and 3'-5' exonuclease proofreading functionQ33594697
Ultraviolet mutagenesis and inducible DNA repair in Escherichia coliQ34072546
DNA polymerase III of Escherichia coli is required for UV and ethyl methanesulfonate mutagenesisQ34631905
Regulation of SOS mutagenesis by proteolysisQ34734770
In vivo stability of the Umu mutagenesis proteins: a major role for RecA.Q35608533
Isolation and characterization of novel plasmid-encoded umuC mutantsQ35968216
Involvement of Escherichia coli DNA polymerase II in response to oxidative damage and adaptive mutationQ35979376
RecA protein of Escherichia coli has a third essential role in SOS mutator activityQ36164939
New recA mutations that dissociate the various RecA protein activities in Escherichia coli provide evidence for an additional role for RecA protein in UV mutagenesisQ36176522
Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein.Q36275662
Isolation and Characterization of Thermosensitive Escherichia coli Mutants Defective in Deoxyribonucleic Acid ReplicationQ36839028
Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase IIIQ37296938
Analysis of DNA polymerases II and 3 in mutants of Escherichia coli thermosensitive for DNA synthesisQ37494843
Mutagenic repair in Escherichia coli: products of the recA gene and of the umuD and umuC genes act at different steps in UV-induced mutagenesisQ37692184
The 'A rule' of mutagen specificity: a consequence of DNA polymerase bypass of non-instructional lesions?Q37713424
Purification of a soluble UmuD'C complex from Escherichia coli. Cooperative binding of UmuD'C to single-stranded DNA.Q38358001
Detection of messenger RNA from the isoleucine-valine operons of Salmonella typhimurium by heterologous DNA-RNA hybridization: Involvement of transfer RNA in transcriptional repressionQ40783410
Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet lightQ40850491
A molecular switch in a replication machine defined by an internal competition for protein ringsQ40952536
Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesisQ40958827
Induction of only one SOS operon, umuDC, is required for SOS mutagenesis in Escherichia coli.Q42512401
Gel fidelity assay measuring nucleotide misinsertion, exonucleolytic proofreading, and lesion bypass efficienciesQ46257980
Specific RecA amino acid changes affect RecA-UmuD'C interactionQ47986850
Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability.Q48033074
Intermolecular cleavage by UmuD-like enzymes: identification of residues required for cleavage and substrate specificityQ50127776
Escherichia coli umuDC mutants: DNA sequence alterations and UmuD cleavageQ54678510
Mutagenic DNA repair in Escherichia coli. XVI. Mutagenesis by ultraviolet light plus delayed photoreversal in recA strains.Q54750574
Escherichia coli mutants temperature-sensitive for DNA synthesisQ69964539
The mutagenesis proteins UmuD' and UmuC prevent lethal frameshifts while increasing base substitution mutationsQ77231587
P4510describes a project that usesImageQuantQ112270642
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
DNA polymerase V complexQ22326847
P304page(s)8919-8924
P577publication date1999-08-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleUmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.
P478volume96

Reverse relations

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Q34102902The Escherichia coli lacZ reversion mutagenicity assay
Q42414957The Roles of UmuD in Regulating Mutagenesis
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Q36018582The aminoglycoside antibiotic kanamycin damages DNA bases in Escherichia coli: caffeine potentiates the DNA-damaging effects of kanamycin while suppressing cell killing by ciprofloxacin in Escherichia coli and Bacillus anthracis
Q42287231The antirepressor needed for induction of linear plasmid-prophage N15 belongs to the SOS regulon.
Q33937507The bacteriophage 434 repressor dimer preferentially undergoes autoproteolysis by an intramolecular mechanism
Q33993202The bacteriophage P1 HumD protein is a functional homolog of the prokaryotic UmuD'-like proteins and facilitates SOS mutagenesis in Escherichia coli
Q30641251The beta clamp targets DNA polymerase IV to DNA and strongly increases its processivity
Q35132450The biochemical basis and in vivo regulation of SOS-induced mutagenesis promoted by Escherichia coli DNA polymerase V (UmuD'2C).
Q34263814The contribution of endogenous sources of DNA damage to the multiple mutations in cancer
Q34536932The dimeric SOS mutagenesis protein UmuD is active as a monomer
Q34244975The discovery of error-prone DNA polymerase V and its unique regulation by RecA and ATP
Q35165373The diverse spectrum of sliding clamp interacting proteins
Q33892878The early detection of frameshift mutations induced by a food-borne carcinogen in rats: a new tool for molecular epidemiology.
Q28834627The efficiency of the translesion synthesis across abasic sites by mitochondrial DNA polymerase is low in mitochondria of 3T3 cells
Q28298627The eureka enzyme: the discovery of DNA polymerase
Q34186298The expanding polymerase universe
Q24683573The human DINB1 gene encodes the DNA polymerase Poltheta
Q29614220The importance of repairing stalled replication forks
Q36099918The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance
Q27692575The mechanisms of UV mutagenesis
Q31422789The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA, and SSB and is specialized for translesion replication
Q40634197The pKO2 linear plasmid prophage of Klebsiella oxytoca.
Q35013042The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control
Q93350332The recombination mediator proteins RecFOR maintain RecA* levels for maximal DNA polymerase V Mut activity
Q34614165The roles of Klenow processing and flap processing activities of DNA polymerase I in chromosome instability in Escherichia coli K12 strains
Q54440494The two inducible responses, SOS and heat-shock, in Escherichia coli act synergistically during Weigle reactivation of the bacteriophage phiX174.
Q44192202The two-step model for translesion synthesis: then and now.
Q41820110Transcriptional modulator NusA interacts with translesion DNA polymerases in Escherichia coli.
Q34205013Transcriptional responses to DNA damage
Q34509062Translesion DNA Synthesis
Q34356338Translesion DNA polymerases
Q39171293Translesion DNA polymerases in eukaryotes: what makes them tick?
Q34389241Translesion DNA synthesis and mutagenesis in prokaryotes.
Q37952001Translesion DNA synthesis in the context of cancer research
Q37775587Translesion DNA synthesis polymerases in DNA interstrand crosslink repair
Q39079498Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases.
Q33953024Translesion synthesis by the UmuC family of DNA polymerases
Q39095697Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene
Q34036796Two distinct modes of RecA action are required for DNA polymerase V-catalyzed translesion synthesis
Q54472760Two processivity clamp interactions differentially alter the dual activities of UmuC.
Q33400985Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
Q33279151UV-induced mutagenesis in Escherichia coli SOS response: a quantitative model
Q41887546UmuD and RecA directly modulate the mutagenic potential of the Y family DNA polymerase DinB.
Q35969100UmuDAb: An Error-Prone Polymerase Accessory Homolog Whose N-Terminal Domain Is Required for Repression of DNA Damage Inducible Gene Expression in Acinetobacter baylyi
Q36023692What a difference a decade makes: insights into translesion DNA synthesis
Q34464872Why do cells have multiple error-prone DNA polymerases?
Q36778894Y-family DNA polymerases and their role in tolerance of cellular DNA damage.
Q24604217poliota, a remarkably error-prone human DNA polymerase
Q35013038poliota-dependent lesion bypass in vitro
Q33995520umuDC-dnaQ Interaction and its implications for cell cycle regulation and SOS mutagenesis in Escherichia coli.
Q33995559umuDC-mediated cold sensitivity is a manifestation of functions of the UmuD(2)C complex involved in a DNA damage checkpoint control

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