Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination

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Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination is …
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P819ADS bibcode2001PNAS...98.8342S
P356DOI10.1073/PNAS.111036998
P932PMC publication ID37441
P698PubMed publication ID11459973
P5875ResearchGate publication ID11881987

P2093author name stringG C Walker
M D Sutton
P2860cites workStructure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activityQ22003979
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Two functional domains of the epsilon subunit of DNA polymerase III.Q54066558
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The appearance of the UmuD'C protein complex in Escherichia coli switches repair from homologous recombination to SOS mutagenesis.Q54647706
Nature of the SOS-inducing signal in Escherichia coli. The involvement of DNA replication.Q54716069
Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coliQ67286950
Mechanism of transient inhibition of DNA synthesis in ultraviolet-irradiated E. coli: inhibition is independent of recA whilst recovery requires RecA protein itself and an additional, inducible SOS functionQ69893640
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The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesisQ72994394
Replisome assembly at oriC, the replication origin of E. coli, reveals an explanation for initiation sites outside an originQ73151265
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All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesisQ24597093
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poliota, a remarkably error-prone human DNA polymeraseQ24604217
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Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathwayQ27938668
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The DNA replication fork in eukaryotic cells.Q27939216
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Cell cycle checkpoints: preventing an identity crisisQ29547644
The importance of repairing stalled replication forksQ29614220
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNAQ29615251
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesionsQ29619958
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpointQ29620700
Pol kappa: A DNA polymerase required for sister chromatid cohesion.Q30305921
DNA polymerases and SOS mutagenesis: can one reconcile the biochemical and genetic data?Q30612494
The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA, and SSB and is specialized for translesion replicationQ31422789
Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme.Q31423540
A model for SOS-lesion-targeted mutations in Escherichia coliQ32001102
RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis.Q33559613
UmuD mutagenesis protein of Escherichia coli: overproduction, purification, and cleavage by RecA.Q33559649
RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activationQ33559704
In vivo stability of the Umu mutagenesis proteins: a major role for RecA.Q35608533
The genetic requirements for UmuDC-mediated cold sensitivity are distinct from those for SOS mutagenesisQ35610220
The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidanceQ36099918
The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysisQ36172976
Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA.Q36182449
Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein.Q36275662
Cold sensitivity induced by overproduction of UmuDC in Escherichia coliQ36357644
Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coliQ36369577
DNA-damaging agents stimulate gene expression at specific loci in Escherichia coliQ36389606
Cleavage of the Escherichia coli lexA protein by the recA proteaseQ36392308
Targeting of the UmuD, UmuD', and MucA' mutagenesis proteins to DNA by RecA proteinQ36514563
The Escherichia coli SOS mutagenesis proteins UmuD and UmuD' interact physically with the replicative DNA polymeraseQ36538298
Fidelity mechanisms in DNA replicationQ37285267
umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homologyQ37522339
The chi psi subunits of DNA polymerase III holoenzyme bind to single-stranded DNA-binding protein (SSB) and facilitate replication of an SSB-coated templateQ38333951
Purification of a soluble UmuD'C complex from Escherichia coli. Cooperative binding of UmuD'C to single-stranded DNA.Q38358001
Localization of bacterial DNA polymerase: evidence for a factory model of replicationQ38548878
Overproduction of the beta subunit of DNA polymerase III holoenzyme reduces UV mutagenesis in Escherichia coliQ39933704
DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cellsQ40410915
Detection of messenger RNA from the isoleucine-valine operons of Salmonella typhimurium by heterologous DNA-RNA hybridization: Involvement of transfer RNA in transcriptional repressionQ40783410
Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet lightQ40850491
Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesisQ40958827
Developmental control of cell cycle regulators: a fly's perspectiveQ41239581
Visualization of two binding sites for the Escherichia coli UmuD'(2)C complex (DNA pol V) on RecA-ssDNA filamentsQ41631964
The organization of replication and transcriptionQ33655131
DNA recombination: the replication connection.Q33677006
Novel DNA polymerases offer clues to the molecular basis of mutagenesisQ33730736
A plethora of lesion-replicating DNA polymerasesQ33732359
Replication of damaged DNA: molecular defect in xeroderma pigmentosum variant cells.Q33771561
PCNA binding proteinsQ33781935
Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesisQ33798128
Mammalian DNA mismatch repairQ33847720
Replication and recombination intersectQ33885019
PriA-directed replication fork restart in Escherichia coliQ33885421
Coping with replication 'train wrecks' in Escherichia coli using Pol V, Pol II and RecA proteinsQ33885426
Devoted to the lagging strand-the subunit of DNA polymerase III holoenzyme contacts SSB to promote processive elongation and sliding clamp assemblyQ33888734
DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factoriesQ33889077
Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 geneQ33920689
The C-terminal domain of dnaQ contains the polymerase binding siteQ33991949
A role for the umuDC gene products of Escherichia coli in increasing resistance to DNA damage in stationary phase by inhibiting the transition to exponential growthQ33993830
umuDC-dnaQ Interaction and its implications for cell cycle regulation and SOS mutagenesis in Escherichia coli.Q33995520
umuDC-mediated cold sensitivity is a manifestation of functions of the UmuD(2)C complex involved in a DNA damage checkpoint controlQ33995559
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.Q34006347
Genetic interactions between the Escherichia coli umuDC gene products and the beta processivity clamp of the replicative DNA polymerase.Q34011389
A coordinated interplay: proteins with multiple functions in DNA replication, DNA repair, cell cycle/checkpoint control, and transcriptionQ34047820
DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machineQ34058015
Xeroderma pigmentosum and related disorders: defects in DNA repair and transcriptionQ34063966
The SOS response: recent insights into umuDC-dependent mutagenesis and DNA damage toleranceQ34090796
UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD'.Q34305929
Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I.Q34311670
Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutant strains but not in recA+ strains of Escherichia coliQ34349964
Subunit-specific degradation of the UmuD/D' heterodimer by the ClpXP protease: the role of trans recognition in UmuD' stabilityQ34490504
Dynamics of DNA replication factories in living cellsQ34508274
Mutagenesis and more: umuDC and the Escherichia coli SOS responseQ34603875
Regulation of SOS mutagenesis by proteolysisQ34734770
Lon-mediated proteolysis of the Escherichia coli UmuD mutagenesis protein: in vitro degradation and identification of residues required for proteolysisQ34756168
UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.Q35588920
A model for a umuDC-dependent prokaryotic DNA damage checkpointQ35600001
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)8342-9
P577publication date2001-07-17
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleManaging DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination
P478volume98