Translesion DNA synthesis polymerases in DNA interstrand crosslink repair

scientific article published on July 2010

Translesion DNA synthesis polymerases in DNA interstrand crosslink repair is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/EM.20573
P698PubMed publication ID20658647

P2093author name stringOrlando D Schärer
The Vinh Ho
P2860cites workCloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymeraseQ22010228
hRAD30 mutations in the variant form of xeroderma pigmentosumQ22010237
The human REV1 gene codes for a DNA template-dependent dCMP transferaseQ22010721
Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinBQ22011012
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7Q24291530
Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-linksQ24297435
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cellsQ24298399
FANCI is a second monoubiquitinated member of the Fanconi anemia pathwayQ24303906
POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308Q24304200
Multiple roles of vertebrate REV genes in DNA repair and recombinationQ24306340
Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forksQ24314325
Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-linksQ24316458
A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zetaQ24323043
Human DNA polymerase iota protects cells against oxidative stressQ24323561
DNA polymerase POLN participates in cross-link repair and homologous recombinationQ24336826
The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutationQ24537096
Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.Q24537135
Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP familyQ24538351
Physical and functional interactions of human DNA polymerase eta with PCNAQ24548300
Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-linksQ24554288
High-efficiency bypass of DNA damage by human DNA polymerase QQ24561381
Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitinationQ24563236
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesisQ24594244
Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iotaQ24597750
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerasesQ24630867
How the fanconi anemia pathway guards the genomeQ24634556
Eukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceQ24645172
Mechanisms of accurate translesion synthesis by human DNA polymerase etaQ24678700
The human DINB1 gene encodes the DNA polymerase PolthetaQ24683573
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repairQ24685928
Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1Q24798898
Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5'-(CpG) motif: model of a malondialdehyde cross-linkQ27633302
Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymeraseQ27649859
Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a.Q27930823
Deoxycytidyl transferase activity of yeast REV1 proteinQ27931173
The yeast Snm1 protein is a DNA 5'-exonucleaseQ27934200
Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycolQ27934657
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, PoletaQ27935465
The beta-lactamase motif in Snm1 is required for repair of DNA double-strand breaks caused by interstrand crosslinks in S. cerevisiaeQ27935474
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
Thymine-thymine dimer bypass by yeast DNA polymerase zetaQ27938043
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase etaQ28115711
Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase etaQ28116380
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2Q28144150
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51Q28202527
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathwayQ28203777
Cisplatin DNA cross-links do not inhibit S-phase and cause only a G2/M arrest in Saccharomyces cerevisiaeQ77908473
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genesQ80194521
Pre-steady-state kinetic studies of protein-template-directed nucleotide incorporation by the yeast Rev1 proteinQ81500351
Potential inhibition of somatic hypermutation by nucleoside analoguesQ83039619
Fanconi anemia (cross)linked to DNA repairQ36353502
Molecular mechanisms of mammalian global genome nucleotide excision repair.Q36389623
DNA interstrand cross-link repair in the cell cycle: a critical role for polymerase zeta in G1 phaseQ36474725
Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genesQ36563030
Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5' to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strandQ36573759
DNA polymerases and human diseasesQ36635532
DNA interstrand cross-link repair in Saccharomyces cerevisiae.Q36649807
Defective replication of psoralen adducts detected at the gene-specific level in xeroderma pigmentosum variant cellsQ36661116
Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta.Q36701342
Low-fidelity DNA synthesis by human DNA polymerase theta.Q36740110
Translesion synthesis: Y-family polymerases and the polymerase switchQ36760898
Translesion synthesis in Escherichia coli: lessons from the NarI mutation hot spotQ36778229
Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequency and altered spectrum in a xeroderma pigmentosum variantQ36796836
Fanconi anemia and DNA replication repairQ36811854
Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesisQ36861158
Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.Q36923850
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteinsQ36927976
Genetic control of excision of Saccharomyces cerevisiae interstrand DNA cross-links induced by psoralen plus near-UV lightQ36974395
Distortion-dependent unhooking of interstrand cross-links in mammalian cell extractsQ37069315
Generation of DNA interstrand cross-links by post-synthetic reductive aminationQ37082772
Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase deltaQ37239015
Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiationQ37344381
Effect of cross-link structure on DNA interstrand cross-link repair synthesisQ37352226
Action mechanism of ABC excision nuclease on a DNA substrate containing a psoralen crosslink at a defined positionQ37404894
Monoubiquitylation in the Fanconi anemia DNA damage response pathwayQ37407530
Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motifQ37431184
Y-family DNA polymerases in mammalian cellsQ37444742
DNA interstrand crosslink repair in mammalian cellsQ37487925
Yeast Rev1 protein is a G template-specific DNA polymeraseQ38291977
DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zetaQ38315759
Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions.Q39125049
Role for DNA polymerase kappa in the processing of N2-N2-guanine interstrand cross-links.Q39143099
Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiaeQ39452783
Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iotaQ39455619
Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cellsQ39456389
DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links.Q39456549
Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.Q39744882
Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebratesQ39777591
The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assemblyQ39986749
DNA polymerase eta reduces the gamma-H2AX response to psoralen interstrand crosslinks in human cellsQ40037588
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutantsQ40050963
REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivoQ40253053
The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repairQ40273191
Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agentsQ40291563
REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated proliferating cell nuclear antigen (PCNA).Q40298475
Mutant rodent cell lines sensitive to ultraviolet light, ionizing radiation and cross-linking agents: a comprehensive survey of genetic and biochemical characteristicsQ40484333
Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cellsQ40643885
Double-strand breaks induce homologous recombinational repair of interstrand cross-links via cooperation of MSH2, ERCC1-XPF, REV3, and the Fanconi anemia pathwayQ41661048
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activityQ41869549
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repairQ41914934
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-linksQ42044832
DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phaseQ42280794
Cloning and sequence of REV7, a gene whose function is required for DNA damage-induced mutagenesis in Saccharomyces cerevisiaeQ42690716
DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproductQ42934957
Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV.Q43125839
Effects of Post-treatment Incubation on Recombinogenesis in Incision-proficient and Incision-deficient Strains of Saccharomyces cerevisiae: II. Recombinogenesis after the Photoaddition of FurocoumarinsQ43498962
S. cerevisiae has three pathways for DNA interstrand crosslink repairQ43819402
Biochemical properties of the human REV1 proteinQ44014772
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C proteinQ44159127
DNA interchain cross-links formed by acrolein and crotonaldehyde.Q44270841
DNA damage-processing pathways involved in the eukaryotic cellular response to anticancer DNA cross-linking drugsQ44904927
Genome-wide identification of genes conferring resistance to the anticancer agents cisplatin, oxaliplatin, and mitomycin C.Q44917929
Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairingQ44978896
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 geneQ45345090
DNA polymerase zeta regulates cisplatin cytotoxicity, mutagenicity, and the rate of development of cisplatin resistance.Q45972378
Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pairQ46745523
Loss of DNA polymerase zeta causes chromosomal instability in mammalian cellsQ46882671
Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activitiesQ50645182
The Drosophila mus 308 gene product, implicated in tolerance of DNA interstrand crosslinks, is a nuclear protein found in both ovaries and embryos.Q52046900
Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.Q52163744
Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro.Q52541352
Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.Q52541355
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.Q52567780
A new DNA polymerase species from Drosophila melanogaster: a probable mus308 gene product.Q52570567
Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways.Q53477995
Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.Q54462984
Evidence for a recombination-independent pathway for the repair of DNA interstrand cross-links based on a site-specific study with nitrogen mustard.Q54568901
Pulsed-field gel electrophoresis analysis of the repair of psoralen plus UVA induced DNA photoadducts in Saccharomyces cerevisiaeQ64389630
Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: the RAD3 system and the RAD51 systemQ64390722
Allelism between pso1-1 and rev3-1 mutants and between pso2-1 and snm1 mutants in Saccharomyces cerevisiaeQ68133592
REV7, a new gene concerned with UV mutagenesis in yeastQ69905798
Evidence for a second function for Saccharomyces cerevisiae Rev1pQ74130085
Saccharomyces cerevisiae lacking Snm1, Rev3 or Rad51 have a normal S-phase but arrest permanently in G2 after cisplatin treatmentQ74297494
Repair of DNA interstrand cross-linksQ34343361
A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agentsQ34512077
Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.Q34571928
DNA polymerase zeta (pol zeta) in higher eukaryotesQ34729967
Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affairQ34770150
DNA polymerases and human diseaseQ34795963
Mechanism of replication-coupled DNA interstrand crosslink repairQ34832238
Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiationQ35067081
Repair of DNA Containing Interstrand Crosslinks in Escherichia coli: Sequential Excision and RecombinationQ35100710
Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesionsQ35221381
UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.Q35588920
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damageQ35792481
DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responsesQ36002324
The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysisQ36172976
REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymeraseQ36182950
The fate of 8-methoxypsoralen photoinduced crosslinks in nuclear and mitochondrial yeast DNA: comparison of wild-type and repair-deficient strainsQ36286355
Complex formation of yeast Rev1 with DNA polymerase eta.Q36315930
A novel ubiquitin ligase is deficient in Fanconi anemiaQ28206919
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insightsQ28252640
Rev1 employs a novel mechanism of DNA synthesis using a protein templateQ28274770
Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl proteinQ28283240
Formation and repair of interstrand cross-links in DNAQ28296085
DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genesQ28506592
Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damageQ28507940
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with AtmQ28586941
A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308Q28589580
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damageQ28646728
The Y-family of DNA polymerasesQ29615308
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and functionQ29617871
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugationQ29619155
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesisQ29619757
Involvement of nucleotide excision repair in a recombination-independent and error-prone pathway of DNA interstrand cross-link repairQ30648450
Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.Q30769976
Requirement for PCNA and RPA in interstrand crosslink-induced DNA synthesisQ30840942
DNA interstrand cross-links induce futile repair synthesis in mammalian cell extractsQ30845806
Partial reconstitution of human interstrand cross-link repair in vitro: characterization of the roles of RPA and PCNA.Q30978715
A model for SOS-lesion-targeted mutations in Escherichia coliQ32001102
Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta.Q32060399
A role for polymerase eta in the cellular tolerance to cisplatin-induced damageQ33226488
Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cellsQ33374963
Repair of laser-localized DNA interstrand cross-links in G1 phase mammalian cellsQ33493863
Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-linksQ33648841
DNA interstrand crosslink repair in mammalian cells: step by stepQ33669915
A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humansQ33856770
Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 geneQ33920689
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitroQ33938237
Interstrand cross-links induce DNA synthesis in damaged and undamaged plasmids in mammalian cell extractsQ33958954
Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domainQ34097492
hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblastsQ34161894
hMutSbeta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitroQ34276816
The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repairQ34343101
P433issue6
P304page(s)552-566
P577publication date2010-07-01
P1433published inEnvironmental and Molecular MutagenesisQ15724469
P1476titleTranslesion DNA synthesis polymerases in DNA interstrand crosslink repair
P478volume51

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cites work (P2860)
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