The RAD6 DNA repair pathway in Saccharomyces cerevisiae: what does it do, and how does it do it?

scientific article published on April 1994

The RAD6 DNA repair pathway in Saccharomyces cerevisiae: what does it do, and how does it do it? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/BIES.950160408
P698PubMed publication ID8031302

P2093author name stringC Lawrence
P2860cites workCloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damageQ27934145
Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genomeQ36699247
Domain structure and functional analysis of the carboxyl-terminal polyacidic sequence of the RAD6 protein of Saccharomyces cerevisiaeQ36785062
Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51Q36819579
The mutagenic potential of unexcised pyrimidine dimers in Saccharomyces cerevisiae, rad1-1 evidence from photoreactivation and pedigree analysisQ41070013
New mutations affecting induced mutagenesis in yeast.Q52871941
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)253-258
P577publication date1994-04-01
P1433published inBioEssaysQ4914614
P1476titleThe RAD6 DNA repair pathway in Saccharomyces cerevisiae: what does it do, and how does it do it?
P478volume16

Reverse relations

cites work (P2860)
Q33856770A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans
Q28144150A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2
Q36749550A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.
Q40015739A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
Q95808120Accumulation of Ade(+) reversions in isoauxotrophic strains ofSaccharomyces cerevisioe allelic inRAD6 during adenine starvation
Q27930823Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a.
Q34661313Adaptive mutation in Saccharomyces cerevisiae
Q73039820Alteration of ultraviolet-induced mutagenesis in yeast through molecular modulation of the REV3 and REV7 gene expression
Q33771455Analysis of damage tolerance pathways in Saccharomyces cerevisiae: a requirement for Rev3 DNA polymerase in translesion synthesis
Q64389525Analysis of spontaneous frameshift mutations in REV1 and rev1-1 strains of Saccharomyces cerevisiae
Q50913062Analyzing the Catalytic Activities and Interactions of Eukaryotic Translesion Synthesis Polymerases.
Q38891869Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair
Q44734385Characterization of C. elegans RING finger protein 1, a binding partner of ubiquitin-conjugating enzyme 1.
Q42622336Characterization of a Moniezia expansa ubiquitin-conjugating enzyme E2 cDNA.
Q46691965Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants
Q29619155Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation
Q35205030Crosstalk between translesion synthesis, Fanconi anemia network, and homologous recombination repair pathways in interstrand DNA crosslink repair and development of chemoresistance
Q27748912Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution
Q33984301DNA damage-induced mutation: tolerance via translesion synthesis
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q45061243Decreased Hrad6B expression in lung cancer
Q33905811Degradation or maintenance: actions of the ubiquitin system on eukaryotic chromatin
Q34617787Delineating the requirements for spontaneous DNA damage resistance pathways in genome maintenance and viability in Saccharomyces cerevisiae
Q27931173Deoxycytidyl transferase activity of yeast REV1 protein
Q39607351Error-prone lesion bypass by human DNA polymerase eta.
Q34750817Generation of a strong mutator phenotype in yeast by imbalanced base excision repair
Q28131737Genome maintenance mechanisms for preventing cancer
Q35646843Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination
Q24682621Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination
Q48060228Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.
Q36565973Incubation at the nonpermissive temperature induces deficiencies in UV resistance and mutagenesis in mouse mutant cells expressing a temperature-sensitive ubiquitin-activating enzyme (E1)
Q28218052Interaction of HIV-1 integrase with DNA repair protein hRad18
Q24291530Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7
Q38362408Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage
Q28506450Knockout mouse model and gametogenic failure
Q43077169Large-scale expansions of Friedreich's ataxia GAA repeats in yeast
Q28587200Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase
Q37559863Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin
Q34932076Mouse models of male infertility.
Q33921111Multiple Rad5 activities mediate sister chromatid recombination to bypass DNA damage at stalled replication forks
Q39777591Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates
Q33770262Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p
Q74247121Mutations of the CDC28 gene and the radiation sensitivity of Saccharomyces cerevisiae
Q39125049Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions.
Q36456075PCNA modifications for regulation of post-replication repair pathways
Q41441687PcG complexes and chromatin silencing
Q38704026Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs
Q34075261Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast
Q42691419Protein-protein interactions within an E2-RING finger complex. Implications for ubiquitin-dependent DNA damage repair
Q39659031RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells
Q35856709RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.
Q37802636RAD18 lives a double life: Its implication in DNA double-strand break repair
Q64981960RAD18 may function as a predictor of response to preoperative concurrent chemoradiotherapy in patients with locally advanced rectal cancer through caspase-9-caspase-3-dependent apoptotic pathway.
Q47955849RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance
Q24311807RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response
Q28589254RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis
Q34092180Rad6 is a Potential Early Marker of Melanoma Development
Q38098472Readers of PCNA modifications
Q37714843Reconstitution of repair-gap UV mutagenesis with purified proteins from Escherichia coli: a role for DNA polymerases III and II.
Q34353641Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae
Q24294393Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation
Q28678572Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease
Q33257837Replication-dependent and -independent responses of RAD18 to DNA damage in human cells
Q38658428Response of human DNA polymerase iota to DNA lesions
Q34336638Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast.
Q28511362Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis
Q42102982Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.
Q34083285Specific aspects of the ubiquitin system in spermatogenesis
Q27933149Specificity of DNA lesion bypass by the yeast DNA polymerase eta.
Q62571320Specificity of platinum–DNA adduct repair
Q61552520Starvation-associated mutagenesis in yeast Saccharomyces cerevisiae is affected by Ras2/cAMP signaling pathway
Q31126133Structural and functional conservation of error-free DNA postreplication repair in Schizosaccharomyces pombe
Q36337954Suffering in silence: the tolerance of DNA damage
Q39530638Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free post-replication repair but not for damage-induced mutagenesis
Q36082840Suppression of gross chromosomal rearrangements by a new alternative replication factor C complex
Q24551106Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response
Q36249152The RAD6 pathway: control of DNA damage bypass and mutagenesis by ubiquitin and SUMO.
Q27936359The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18
Q24813831The RING finger ATPase Rad5p of Saccharomyces cerevisiae contributes to DNA double-strand break repair in a ubiquitin-independent manner
Q24616365The Role of PCNA Posttranslational Modifications in Translesion Synthesis
Q27935826The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways
Q80597464The association between RAD18 Arg302Gln polymorphism and the risk of human non-small-cell lung cancer
Q34115863The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination
Q22254654The human RAD18 gene product interacts with HHR6A and HHR6B
Q22010721The human REV1 gene codes for a DNA template-dependent dCMP transferase
Q24322863The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells
Q35013042The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control
Q37711890The sperm nucleus: chromatin, RNA, and the nuclear matrix.
Q39097785The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathway
Q33690285The ubiquitin system in gametogenesis
Q28587712The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice
Q36268060The ubiquitin-proteasome system of Saccharomyces cerevisiae
Q37878585Timing and spacing of ubiquitin-dependent DNA damage bypass
Q33953024Translesion synthesis by the UmuC family of DNA polymerases
Q40695817Translesion synthesis of acetylaminofluorene-dG adducts by DNA polymerase zeta is stimulated by yeast Rev1 protein
Q27935427Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.
Q38201972Two-way communications between ubiquitin-like modifiers and DNA.
Q37871655Ubiquitin family modifications and template switching
Q63965414Ubiquitin signalling in DNA replication and repair
Q41170108Ubiquitin-dependent DNA damage bypass is separable from genome replication
Q71739748Ubiquitin-mediated proteolysis and male sterility
Q61552544Uracilless death and papillae formation inrad6-1 polyauxotrophic strains ofSaccharomyces cerevisiae
Q47732691Utility of DNA postreplication repair protein Rad6B in neoadjuvant chemotherapy response
Q41869549Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
Q24303602ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins
Q48073417dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues

Search more.