Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis

scientific article

Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0092-8674(00)81323-9
P3181OpenCitations bibliographic resource ID114713
P698PubMed publication ID8858149
P5875ResearchGate publication ID14347597

P2093author name stringJ A Simon
R M Liskay
T A Kunkel
A Umar
D C Thomas
A B Clark
A B Buermeyer
P2860cites workInteraction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigenQ24308837
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNAQ27730804
Mammalian Ras interacts directly with the serine/threonine kinase RafQ27860833
A novel genetic system to detect protein-protein interactionsQ27860915
Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear AntigenQ27931829
A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistanceQ28131606
Proliferating cell nuclear antigen is required for DNA excision repairQ28182009
Transcription-coupled repair deficiency and mutations in human mismatch repair genesQ28276963
Biochemistry and genetics of eukaryotic mismatch repairQ28282377
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor CellsQ28292781
Structure-Function Relationship of the Eukaryotic DNA Replication Factor, Proliferating Cell Nuclear AntigenQ28297396
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigenQ28303106
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Q28505037
Meiotic pachytene arrest in MLH1-deficient miceQ28510650
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNAQ29615251
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repairQ29618879
The distribution of the numbers of mutants in bacterial populationsQ29620123
Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid systemQ29620436
Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell linesQ33720790
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzymeQ35739744
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.Q36412005
A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repairQ36553838
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
Mechanisms and biological effects of mismatch repairQ37041860
High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12.Q40388905
A yeast mating-selection scheme for detection of protein-protein interactionsQ40399743
Single-step purification of shuttle vectors from yeast for high frequency back-transformation into E. coliQ40523810
Instability of simple sequence DNA in Saccharomyces cerevisiaeQ40655124
Smart machines at the DNA replication fork.Q40704705
DNA-replication fidelity, mismatch repair and genome instability in cancer cellsQ41016785
Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repairQ41423739
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.Q41436520
Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.Q41676798
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2.Q48065235
Analyzing fidelity of DNA polymerases.Q54619712
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patientsQ57570041
The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair systemQ71806485
Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21Q72036862
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectProliferating cell nuclear antigen YBR088CQ27550140
DNA mismatch repairQ2984243
P304page(s)65-73
P577publication date1996-10-04
P1433published inCellQ655814
P1476titleRequirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
P478volume87

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cites work (P2860)
Q74301501"Malgun" (clear) cell change of gastric epithelium in chronic Helicobacter pylori gastritis
Q24554315A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage
Q36677284A Delicate Balance Between Repair and Replication Factors Regulates Recombination Between Divergent DNA Sequences in Saccharomyces cerevisiae
Q30433118A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA
Q24298110A defined human system that supports bidirectional mismatch-provoked excision
Q40863779A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation
Q33698648A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy
Q24306061A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation
Q34606404A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences
Q36540457A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair
Q28082955A proposal: Evolution of PCNA's role as a marker of newly replicated DNA
Q28217331A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein
Q28534685A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability
Q43732373ATP utilization by yeast replication factor C. IV. RFC ATP-binding mutants show defects in DNA replication, DNA repair, and checkpoint regulation
Q27939412ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes
Q28610858ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
Q34616364Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes
Q28910215Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
Q31076593An expanded view of bacterial DNA replication.
Q24642184An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joining
Q27934521Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae
Q73893732Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA
Q33333897Archaeal DNA replication: identifying the pieces to solve a puzzle.
Q35291466Balancing eukaryotic replication asymmetry with replication fidelity.
Q40077513Base Flipping within the α-Hemolysin Latch Allows Single-Molecule Identification of Mismatches in DNA.
Q34443496Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae
Q36597002Beta clamp directs localization of mismatch repair in Bacillus subtilis
Q33726437Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks
Q45129820Cadmium inhibits the functions of eukaryotic MutS complexes.
Q37142738Cadmium is a mutagen that acts by inhibiting mismatch repair.
Q41617067Cancer cells exhibit a mutator phenotype
Q53061316Cell cycle and mismatch repair genes as potential biomarkers in Arabidopsis thaliana seedlings exposed to silver nanoparticles.
Q36199684Cell survival after UV radiation stress in the unicellular chlorophyte Dunaliella tertiolecta is mediated by DNA repair and MAPK phosphorylation
Q37072156Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair
Q27934255Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae
Q28277364Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2
Q34606398Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader
Q47791987Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase delta
Q24611973Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells
Q42424836Clamping down on mismatches
Q24650948Comparative genomics and molecular dynamics of DNA repeats in eukaryotes
Q74801797Complementation of mismatch repair gene defects by chromosome transfer
Q39652175Conservation of functional asymmetry in the mammalian MutLα ATPase
Q33559854Construction and characterization of mismatch-containing circular DNA molecules competent for assessment of nick-directed human mismatch repair in vitro
Q40744193Contribution of human mlh1 and pms2 ATPase activities to DNA mismatch repair
Q75404779Correlation between patterns of DNA mismatch repair hmlh1 and hmsh2 protein expression and progression of dysplasia in intraductal papillary mucinous neoplasms of the pancreas
Q27640487Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair
Q92368872DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging
Q36884849DNA Mismatch Repair Interacts with CAF-1- and ASF1A-H3-H4-dependent Histone (H3-H4)2 Tetramer Deposition
Q34967180DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.
Q41441658DNA excision repair pathways
Q30993657DNA methylation, methyltransferases, and cancer
Q31530974DNA methylation: past, present and future directions
Q40513970DNA methyltransferase Dnmt1 and mismatch repair
Q39674490DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair
Q34298096DNA methyltransferases, DNA damage repair, and cancer
Q36527421DNA mismatch repair and Lynch syndrome
Q28211143DNA mismatch repair and mutation avoidance pathways
Q34568596DNA mismatch repair defects: role in colorectal carcinogenesis
Q28291067DNA mismatch repair in eukaryotes and bacteria
Q41536289DNA mismatch repair in mammals: role in disease and meiosis
Q36453321DNA mismatch repair system. Classical and fresh roles
Q40478691DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.
Q24647002DNA mismatch repair: molecular mechanism, cancer, and ageing
Q26991961DNA polymerase delta in DNA replication and genome maintenance
Q24313002DNA polymerase delta is required for human mismatch repair in vitro
Q37709141DNA polymerase delta, RFC and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae.
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q46002898DNA replication and postreplication mismatch repair in cell-free extracts from cultured human neuroblastoma and fibroblast cells.
Q28295863DNA replication fidelity and cancer
Q38612559DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro.
Q64387816DNA template requirements for human mismatch repair in vitro
Q34603838Damage control: the pleiotropy of DNA repair genes in Drosophila melanogaster
Q40453633De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine.
Q33888905Deficiency of a novel mismatch repair activity in a bladder tumor cell line
Q28592891Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
Q35034387Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast.
Q34396924Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta}
Q44761854Differential requirement for proliferating cell nuclear antigen in 5' and 3' nick-directed excision in human mismatch repair
Q40725491Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen.
Q33645614Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha
Q27679146Distinct Structural Alterations in Proliferating Cell Nuclear Antigen Block DNA Mismatch Repair
Q33460873Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells
Q45962906DnaN clamp zones provide a platform for spatiotemporal coupling of mismatch detection to DNA replication.
Q40405040Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells
Q42478039Does drug abuse alter microglial phenotype and cell turnover in the context of advancing HIV infection?
Q28534756Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway
Q34608363Dominant mutations in three different subunits of replication factor C suppress replication defects in yeast PCNA mutants
Q57272811Dual recognition–incision enzymes might be involved in mismatch repair and meiosis
Q30496957Dynamic basis for one-dimensional DNA scanning by the mismatch repair complex Msh2-Msh6.
Q35250218Dynamic interrelationships between DNA replication, methylation, and repair
Q34609730EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae
Q77918828Effect of p21waf1/cip1 transgene on radiation induced apoptosis in T cells
Q36764079Endonuclease activities of MutLα and its homologs in DNA mismatch repair
Q37438949Epigenetic Enhancement of the Post-replicative DNA Mismatch Repair of Mammalian Genomes by a Hemi-(m)CpG-Np95-Dnmt1 Axis
Q35210734Epigenetic mechanisms and genome stability.
Q27939116Eukaryotic DNA mismatch repair
Q33850056Eukaryotic DNA polymerases, a growing family
Q77753605Eukaryotic mismatch repair: an update
Q38355096Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in Yeast
Q24316068Evidence for involvement of HMGB1 protein in human DNA mismatch repair
Q35115265Evidence for short-patch mismatch repair in Saccharomyces cerevisiae
Q36115776Evidence that the DNA mismatch repair system removes 1-nucleotide Okazaki fragment flaps
Q27692024Examination of the expanding pathways for the regulation of p21 expression and activity
Q36553485Exonuclease 1 preferentially repairs mismatches generated by DNA polymerase α
Q34918066Exposure to the polyester PET precursor--terephthalic acid induces and perpetuates DNA damage-harboring non-malignant human breast cells
Q37049546Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
Q43733995Fidelity of uracil-initiated base excision DNA repair in DNA polymerase beta-proficient and -deficient mouse embryonic fibroblast cell extracts
Q36568343Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins
Q33791245Frameshift mutation, microsatellites and mismatch repair
Q36083305Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae.
Q36570003Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations
Q24290314Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes
Q34425450Functional interactions and signaling properties of mammalian DNA mismatch repair proteins
Q27659620Functional residues on the surface of the N-terminal domain of yeast Pms1
Q27939611Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
Q27929951Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.
Q33836026Genomic and epigenetic instability in colorectal cancer pathogenesis
Q52551102Germline mutations at microsatellite loci in homozygous and heterozygous mutants for mismatch repair and PCNA genes in Drosophila.
Q37022515High-fidelity correction of genomic uracil by human mismatch repair activities
Q24307401Highlight: BRCA1 and BRCA2 proteins in breast cancer
Q30356611Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.
Q33939108Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites
Q36328799Human DNA mismatch repair: coupling of mismatch recognition to strand-specific excision
Q73794909Human DNA repair genes
Q22299424Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1
Q74249580Human DNA-demethylating activity: a glycosylase associated with RNA and PCNA
Q31119964Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain
Q33343475Human MutLalpha: the jack of all trades in MMR is also an endonuclease
Q24292187Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6
Q24292224Human exonuclease I is required for 5' and 3' mismatch repair
Q33224078Human mismatch repair: reconstitution of a nick-directed bidirectional reaction
Q73230479Human-Saccharomyces cerevisiae proliferating cell nuclear antigen hybrids: oligomeric structure and functional characterization using in vitro DNA replication
Q36568353Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.
Q40762811Identification and functional characterization of the promoter region of the human MSH6 gene
Q90647988Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners
Q37370959Identification of factors influencing strand bias in oligonucleotide-mediated recombination in Escherichia coli
Q22254324Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis
Q42972358Identifying protein-protein interactions in somatic hypermutation
Q34994580Immunological disorders and DNA repair
Q41066084Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA.
Q33967139Inactivation of DNA mismatch repair by increased expression of yeast MLH1.
Q30356382Incision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extracts
Q39455847Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta
Q40698673Inhibition of the expression of alpha-smooth muscle actin in human hepatic stellate cell line, LI90, by a selective cyclooxygenase 2 inhibitor, NS-398.
Q33812133Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1
Q81606781Interaction between proliferating cell nuclear antigen (PCNA) and a DnaJ induced by DNA damage
Q45144500Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe
Q33719300Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair.
Q34311670Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I.
Q33933718Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae
Q28209230Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX
Q33984323Interrelationships between DNA repair and DNA replication
Q47135454Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae.
Q39675432Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair
Q34012877Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast
Q37215085Loading clamps for DNA replication and repair
Q22009114MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1
Q41842089Malgun (clear) cell change in Helicobacter pylori gastritis reflects epithelial genomic damage and repair
Q33775234Mapping the polarity of changes that occur in interrupted CAG repeat tracts in yeast
Q34614229Maternal effect for DNA mismatch repair in the mouse.
Q77973899Maternal or paternal exposure to radiation increases susceptibility to the induction of glutathione S-transferase-positive hepatic foci in offspring rats
Q24300483Mechanism of 5'-directed excision in human mismatch repair
Q28262719Mechanisms and functions of DNA mismatch repair
Q37540260Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture).
Q36564560Mechanisms in eukaryotic mismatch repair
Q39293345Mechanisms of DNA damage, repair, and mutagenesis
Q34609166Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
Q35910256Meiotic recombination intermediates and mismatch repair proteins
Q33305049Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA)
Q36283640Mismatch repair
Q33756019Mismatch repair and immunoglobulin gene hypermutation: did we learn something?
Q34446700Mismatch repair balances leading and lagging strand DNA replication fidelity.
Q34194518Mismatch repair in correction of replication errors and processing of DNA damage
Q33984294Mismatch repair proteins and mitotic genome stability
Q34367191Molecular mechanism of PCNA-dependent base excision repair
Q34293069Molecular mechanisms of DNA mismatch repair
Q40384769Molecular structures of crossover and noncrossover intermediates during gap repair in yeast: implications for recombination
Q33739279Mouse models for colorectal cancer
Q28214396Mouse models for human DNA mismatch-repair gene defects
Q78681880Msh2 deficiency increases the mutation frequency in all parts of the mouse colon
Q44522189Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair
Q28776215Multiple functions of MutS- and MutL-related heterocomplexes
Q33530108MutS and MutL are dispensable for maintenance of the genomic mutation rate in the halophilic archaeon Halobacterium salinarum NRC-1.
Q50989071MutS stimulates the endonuclease activity of MutL in an ATP-hydrolysis-dependent manner.
Q39612088MutSα maintains the mismatch repair capability by inhibiting PCNA unloading.
Q47676846Mutation frequency analysis of mononucleotide and dinucleotide repeats after oxidative stress
Q36107008Mutations at the Subunit Interface of Yeast Proliferating Cell Nuclear Antigen Reveal a Versatile Regulatory Domain
Q36573422Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon
Q42797357Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication
Q37256683Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity
Q53412320Mutator phenotype due to loss of heterozygosity in diploid yeast strains with mutations in MSH2 and MLH1.
Q33957827Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.
Q34609246Mutual correction of faulty PCNA subunits in temperature-sensitive lethal mus209 mutants of Drosophila melanogaster
Q35313485N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1
Q44062505NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines
Q28084645New insights into the mechanism of DNA mismatch repair
Q36540667Non-canonical actions of mismatch repair
Q34097342Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication
Q33643516Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage
Q83420323Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2
Q30801356Oxidative damage-induced PCNA complex formation is efficient in xeroderma pigmentosum group A but reduced in Cockayne syndrome group B cells
Q40726505Oxidative stress inactivates the human DNA mismatch repair system.
Q33961620PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.
Q34151839PCNA and MutLα: partners in crime in triplet repeat expansion?
Q28204459PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA
Q24606670PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
Q33851302PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage
Q37011650Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity
Q28610670Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A
Q30978715Partial reconstitution of human interstrand cross-link repair in vitro: characterization of the roles of RPA and PCNA.
Q35590357Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis
Q92282100Phosphorylation of proliferating cell nuclear antigen promotes cancer progression by activating the ATM/Akt/GSK3β/Snail signaling pathway
Q34578809Physical and functional interaction of human nuclear uracil-DNA glycosylase with proliferating cell nuclear antigen
Q27690911Postreplicative mismatch repair
Q40309902Postreplicative mismatch repair factors are recruited to Epstein-Barr virus replication compartments
Q30397641Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation
Q28142999Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex
Q36179739Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase delta
Q47714565Protein-PCNA interactions: a DNA-scanning mechanism?
Q35562597Protein−Protein Interactions Involving DNA Glycosylases
Q46709248RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells
Q24805338Recognition and binding of mismatch repair proteins at an oncogenic hot spot
Q41886077Recognition of DNA alterations by the mismatch repair system
Q37319600Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins
Q33388647Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites
Q24533222Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen
Q28138082Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen
Q37625834Regulation of interactions with sliding clamps during DNA replication and repair.
Q34608647Regulation of mitotic homeologous recombination in yeast. Functions of mismatch repair and nucleotide excision repair genes
Q33865368Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae
Q52929756Repair bias of large loop mismatches during recombination in mammalian cells depends on loop length and structure.
Q42660015Replication errors: cha(lle)nging the genome
Q28610371Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA
Q40748374Replication-associated repair of adenine:8-oxoguanine mispairs by MYH.
Q38336291Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae
Q33744407Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway
Q38751208Review: The lord of the rings: Structure and mechanism of the sliding clamp loader
Q28689053Ribonucleotides are signals for mismatch repair of leading-strand replication errors
Q34194512Role of MED1 (MBD4) Gene in DNA repair and human cancer
Q54244033Role of hMLH1 and E-cadherin promoter methylation in gastric cancer progression.
Q27938184Role of proliferating cell nuclear antigen interactions in the mismatch repair-dependent processing of mitotic and meiotic recombination intermediates in yeast
Q39869495Role of the checkpoint clamp in DNA damage response
Q33792439Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase
Q34057743Roles for mismatch repair factors in regulating genetic recombination
Q36687824Roles of DNA polymerases in replication, repair, and recombination in eukaryotes.
Q36549257Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease
Q39449001Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair
Q27938377Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination
Q36778041Sequence divergence impedes crossover more than noncrossover events during mitotic gap repair in yeast
Q39724103Single point mutations located outside the inter-monomer domains abolish trimerization of Schizosaccharomyces pombe PCNA
Q26999680Single-molecule views of MutS on mismatched DNA.
Q77198198Somatic hypermutation, transcription, and DNA mismatch repair
Q40214237Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells
Q54089766Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines.
Q57784305Stochastic Processes and Component Plasticity Governing DNA Mismatch Repair
Q41602506Strand-specific mismatch repair in mammalian cells
Q28285134Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities
Q34463842Structure and function of mammalian DNA ligases
Q28143945Structure and function of mismatch repair proteins
Q27684073Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site
Q27651596Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening
Q48001444Sulindac and Celecoxib regulate cell cycle progression by p53/p21 up regulation to induce apoptosis during initial stages of experimental colorectal cancer.
Q38315591Testing excision models for responses of mismatch-repair systems to UV photoproducts in DNA.
Q33957467The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae
Q38307086The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts
Q77765360The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity
Q28551589The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis
Q51312086The Major Replicative Histone Chaperone CAF-1 Suppresses the Activity of the DNA Mismatch Repair System in the Cytotoxic Response to a DNA-methylating Agent.
Q36961147The Many Roles of PCNA in Eukaryotic DNA Replication
Q24657814The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair
Q36026779The N terminus of Saccharomyces cerevisiae Msh6 is an unstructured tether to PCNA
Q35813300The PCNA-RFC families of DNA clamps and clamp loaders
Q27931779The RAD52 recombinational repair pathway is essential in pol30 (PCNA) mutants that accumulate small single-stranded DNA fragments during DNA synthesis
Q27935826The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways
Q28594399The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation
Q36143813The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels
Q34979711The activity and stability of the intrinsically disordered Cip/Kip protein family are regulated by non-receptor tyrosine kinases
Q52569390The beta sliding clamp binds to multiple sites within MutL and MutS.
Q35165373The diverse spectrum of sliding clamp interacting proteins
Q34607157The effect of DNA replication mutations on CAG tract stability in yeast.
Q34895336The effects of mismatch repair and RAD1 genes on interchromosomal crossover recombination in Saccharomyces cerevisiae
Q52652903The effects of mutations in the genes of DNA reparation system on the mutability of unstable sex-linked alleles of Drosophila melanogaster.
Q34528290The endonuclease domain of MutL interacts with the β sliding clamp
Q36718848The involvement of DNA-damage and -repair defects in neurological dysfunction
Q33984289The many faces of mismatch repair in meiosis
Q36448284The multifaceted mismatch-repair system
Q35943962The nucleosome binding protein HMGN1 interacts with PCNA and facilitates its binding to chromatin
Q34551905The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells
Q33592366The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae
Q34606599The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast.
Q41612088The roles of the eukaryotic DNA polymerases in DNA repair synthesis
Q33742371Therapeutic effects of matrine on primary and metastatic breast cancer
Q24298905Thymosin beta 4 expression and nuclear transport are regulated by hMLH1
Q44219222Transfer of the MSH2.MSH6 complex from proliferating cell nuclear antigen to mispaired bases in DNA.
Q28473885Two estrogen response element sequences near the PCNA gene are not responsible for its estrogen-enhanced expression in MCF7 cells
Q24317732Tyrosine phosphorylation controls PCNA function through protein stability
Q38940317Understanding how mismatch repair proteins participate in the repair/anti-recombination decision
Q37307610Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression
Q36338245Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.
Q43846779Visualization of mismatch repair in bacterial cells
Q34193203Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice
Q33299607XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions
Q39253075Xenopus egg extract: A powerful tool to study genome maintenance mechanisms
Q52644492YB-1 disrupts mismatch repair complex formation, interferes with MutSα recruitment on mismatch and inhibits mismatch repair through interacting with PCNA.
Q27935389exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair
Q24602221hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
Q34276816hMutSbeta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitro
Q28213871p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues
Q30436015p21 in cancer: intricate networks and multiple activities

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