exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair

scientific article

exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.21.15.5142-5155.2001
P3181OpenCitations bibliographic resource ID123310
P932PMC publication ID87239
P698PubMed publication ID11438669
P5875ResearchGate publication ID11901865

P2093author name stringR D Kolodner
S Oh
M N Nguyen
N S Amin
P2860cites workIsolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extractsQ22009456
Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexesQ24290314
DNA polymerase delta is required for human mismatch repair in vitroQ24313002
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
The Saccharomyces cerevisiae protein YJR043C (Pol32) interacts with the catalytic subunit of DNA polymerase alpha and is required for cell cycle progression in G2/MQ77937435
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
An atypical topoisomerase II from Archaea with implications for meiotic recombinationQ29618230
The distribution of the numbers of mutants in bacterial populationsQ29620123
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell linesQ29620526
Microsatellite instability in cancer of the proximal colonQ29620692
Mismatch repair in Escherichia coli cells lacking single-strand exonucleases ExoI, ExoVII, and RecJQ33724726
Mismatch repair defects in cancerQ33885063
Functional interaction between the Werner Syndrome protein and DNA polymerase deltaQ33899465
Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiaeQ33933718
Unlinked noncomplementation: isolation of new conditional-lethal mutations in each of the tubulin genes of Saccharomyces cerevisiaeQ33954146
The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiaeQ33957467
Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Q33957827
Genetic evidence for functional interactions between actin noncomplementing (Anc) gene products and actin cytoskeletal proteins in Saccharomyces cerevisiaeQ33961605
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loaderQ34606398
A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequencesQ34606404
EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiaeQ34609730
Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiaeQ34611088
A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repairQ36553838
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitroQ36568265
Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.Q36568353
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutationsQ36570003
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
Structure and processivity of two forms of Saccharomyces cerevisiae DNA polymerase deltaQ38335236
hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalphaQ38336441
Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repairQ39449001
Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genesQ40022200
Microsatellite instability in inherited and sporadic neoplasmsQ40493550
Mismatch Repair Deficiency in Phenotypically Normal Human CellsQ41347026
Novel dominant mutations in Saccharomyces cerevisiae MSH6.Q41711225
Single-strand DNA-specific exonucleases in Escherichia coli. Roles in repair and mutation avoidance.Q41777210
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repairQ46348708
Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase deltaQ47791987
A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.Q53963518
Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal CancerQ61946741
A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repairQ64389285
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomasQ70972741
POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase delta, defines a link between DNA replication and the mutagenic bypass repair pathwayQ73319794
Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high-level microsatellite instabilityQ73911349
Methylation of hMLH1 in a population-based series of endometrial carcinomasQ74352335
The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repairQ24321288
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6Q24323176
Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repairQ27617873
Crystal structures of mismatch repair protein MutS and its complex with a substrate DNAQ27627633
The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatchQ27627644
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNAQ27730804
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesisQ27766073
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiaeQ27860636
Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.Q27929951
Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repairQ27932017
Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complexQ27932428
The product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, specifically functions in mitochondriaQ27933751
Role of yeast Rth1 nuclease and its homologs in mutation avoidance, DNA repair, and DNA replicationQ27934260
A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognitionQ27934451
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
A requirement for recombinational repair in Saccharomyces cerevisiae is caused by DNA replication defects of mec1 mutantsQ27935496
Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repairQ27938608
Eukaryotic DNA mismatch repairQ27939116
ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexesQ27939412
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesisQ27939891
Multifunctional yeast high-copy-number shuttle vectorsQ28131605
The interaction of the human MutL homologues in hereditary nonpolyposis colon cancerQ28137782
Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiaeQ28140402
Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complexQ28142999
Biochemistry and genetics of eukaryotic mismatch repairQ28282377
Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombinationQ28289308
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor CellsQ28292781
hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNAQ28610839
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairQ28610858
Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalphaQ28610863
Multiple functions of MutS- and MutL-related heterocomplexesQ28776215
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
DNA mismatch repairQ2984243
Rad2 family nuclease EXO1 YOR033CQ27548669
P304page(s)5142-55
P577publication date2001-08-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleexo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair
P478volume21

Reverse relations

cites work (P2860)
Q24298110A defined human system that supports bidirectional mismatch-provoked excision
Q93270681A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance
Q36749550A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.
Q36540457A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair
Q37181822A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair
Q36457060ATR-dependent pathways control hEXO1 stability in response to stalled forks.
Q35690218Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
Q40248007Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis
Q28513971Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
Q34614513Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.
Q33791321Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1.
Q37351850C-terminal flap endonuclease (rad27) mutations: lethal interactions with a DNA ligase I mutation (cdc9-p) and suppression by proliferating cell nuclear antigen (POL30) in Saccharomyces cerevisiae
Q37072156Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair
Q24302011Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA
Q27934255Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae
Q35865056Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins.
Q35881387Chromosome position determines the success of double-strand break repair
Q35782915Colorectal cancer as a complex disease: defining at-risk subjects in the general population - a preventive strategy
Q38351980Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability
Q34611390Cotransport of the heterodimeric small subunit of the Saccharomyces cerevisiae ribonucleotide reductase between the nucleus and the cytoplasm
Q36884849DNA Mismatch Repair Interacts with CAF-1- and ASF1A-H3-H4-dependent Histone (H3-H4)2 Tetramer Deposition
Q28211143DNA mismatch repair and mutation avoidance pathways
Q36540658DNA mismatch repair and the DNA damage response
Q34568596DNA mismatch repair defects: role in colorectal carcinogenesis
Q37685729DNA mismatch repair gene MSH6 implicated in determining age at natural menopause
Q24647002DNA mismatch repair: molecular mechanism, cancer, and ageing
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q34297803DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum
Q28295863DNA replication fidelity and cancer
Q33888905Deficiency of a novel mismatch repair activity in a bladder tumor cell line
Q35910908Detection of activity centers in cellular pathways using transcript profiling
Q35034387Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast.
Q34396924Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta}
Q44761854Differential requirement for proliferating cell nuclear antigen in 5' and 3' nick-directed excision in human mismatch repair
Q28534756Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway
Q39882599Drug-sensitive DNA polymerase δ reveals a role for mismatch repair in checkpoint activation in yeast.
Q48587042EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells
Q92203157Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex
Q47632050Embryonic-endometrial interactions at implantation in humans
Q36764079Endonuclease activities of MutLα and its homologs in DNA mismatch repair
Q36436073Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair
Q73576845Enhanced expression of the DNA damage-inducible gene DIN7 results in increased mutagenesis of mitochondrial DNA in Saccharomyces cerevisiae
Q33711830Eukaryotic Mismatch Repair in Relation to DNA Replication
Q24316068Evidence for involvement of HMGB1 protein in human DNA mismatch repair
Q28551519Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites
Q35564759Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zeta
Q90292067Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian Cancer
Q36421123Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents
Q38919536Exonuclease 1 and its versatile roles in DNA repair
Q36553485Exonuclease 1 preferentially repairs mismatches generated by DNA polymerase α
Q28261787Exonuclease 1-dependent and independent mismatch repair
Q33739955Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions
Q24619622Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation
Q28185113Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability
Q35318165Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1
Q47766916Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro
Q60934518Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer
Q31119964Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain
Q24292224Human exonuclease I is required for 5' and 3' mismatch repair
Q33224078Human mismatch repair: reconstitution of a nick-directed bidirectional reaction
Q33791326Hydrolytic function of Exo1 in mammalian mismatch repair.
Q90647988Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners
Q36741556Identification of regulatory factor X as a novel mismatch repair stimulatory factor
Q38358603Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity
Q28182219Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
Q24629057Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex
Q33933718Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae
Q47135454Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae.
Q39675432Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair
Q36991032Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes
Q51793302Measuring strand discontinuity-directed mismatch repair in yeast Saccharomyces cerevisiae by cell-free nuclear extracts.
Q24300483Mechanism of 5'-directed excision in human mismatch repair
Q28262719Mechanisms and functions of DNA mismatch repair
Q43990123Mismatch repair in human nuclear extracts. Time courses and ATP requirements for kinetically distinguishable steps leading to tightly controlled 5' to 3' and aphidicolin-sensitive 3' to 5' mispair-provoked excision
Q42936455Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication
Q35165645Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae
Q91404367MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair
Q50989071MutS stimulates the endonuclease activity of MutL in an ATP-hydrolysis-dependent manner.
Q39612088MutSα maintains the mismatch repair capability by inhibiting PCNA unloading.
Q34123282Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha
Q28084645New insights into the mechanism of DNA mismatch repair
Q26822478Nucleases in homologous recombination as targets for cancer therapy
Q57009219Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1
Q37037194O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo
Q33961620PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.
Q37482417PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.
Q37271214PCNA promotes processive DNA end resection by Exo1.
Q28610670Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A
Q27938949Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway
Q64132285Quantitative trait loci analysis of heat stress resistance of spermatocytes in the MRL/MpJ mouse
Q36972154Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
Q34187018Rapid analysis of Saccharomyces cerevisiae genome rearrangements by multiplex ligation-dependent probe amplification
Q33556873Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins
Q37319600Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins
Q33317311Rice exonuclease-1 homologue, OsEXO1, that interacts with DNA polymerase lambda and RPA subunit proteins, is involved in cell proliferation
Q27931230Saccharomyces cerevisiae Msh2-Msh3 acts in repair of base-base mispairs
Q33667306Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats
Q28242820Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae.
Q34243555Sgs1 and Exo1 suppress targeted chromosome duplication during ends-in and ends-out gene targeting.
Q26999680Single-molecule views of MutS on mismatched DNA.
Q40412801Somatic hypermutation and mismatch repair in non-B cells
Q27684073Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site
Q27667527Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
Q34463536Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair
Q28301386Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions
Q27932484The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains
Q91595501The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair
Q54442651Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.
Q96022920Tumour predisposition and cancer syndromes as models to study gene-environment interactions
Q36338245Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.

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