| scholarly article | Q13442814 |
| P356 | DOI | 10.1126/SCIENCE.7632227 |
| P953 | full work available at URL | https://www.science.org/doi/pdf/10.1126/science.7632227 |
| P698 | PubMed publication ID | 7632227 |
| P50 | author | Bert Vogelstein | Q827502 |
| Kenneth W. Kinzler | Q28031580 | ||
| Paul L. Modrich | Q7151888 | ||
| Ramon Parsons | Q91826937 | ||
| P2093 | author name string | B. Liu | |
| S. R. Hamilton | |||
| M. Longley | |||
| G. M. Li | |||
| T. Berk | |||
| P2860 | cites work | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
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| Mutation of a mutL homolog in hereditary colon cancer | Q28114939 | ||
| The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer | Q28256988 | ||
| Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer | Q28257360 | ||
| Genetic mapping of a locus predisposing to human colorectal cancer | Q28268634 | ||
| Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair | Q29618879 | ||
| Microsatellite instability in cancer of the proximal colon | Q29620692 | ||
| A second-generation linkage map of the human genome | Q33192755 | ||
| The multistep nature of cancer | Q34366937 | ||
| Evolution of hereditary non-polyposis colorectal cancer | Q34395444 | ||
| Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs | Q34554581 | ||
| The molecular basis of Turcot's syndrome | Q34662365 | ||
| Too many rodent carcinogens: mitogenesis increases mutagenesis | Q37848515 | ||
| Cell proliferation in carcinogenesis | Q37951208 | ||
| Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay | Q40187714 | ||
| High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12. | Q40388905 | ||
| Mismatch repair, genetic stability, and cancer | Q40556409 | ||
| Apoptosis (the 1992 Frank Rose Memorial Lecture). | Q40874676 | ||
| Hypermutability and mismatch repair deficiency in RER+ tumor cells | Q41508298 | ||
| MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast | Q42427955 | ||
| Clues to the pathogenesis of familial colorectal cancer | Q42622043 | ||
| Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer | Q48084125 | ||
| Hereditary gastrointestinal polyposis and nonpolyposis syndromes. | Q54622109 | ||
| Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer | Q57568035 | ||
| Mismatch repair and cancer | Q57956407 | ||
| Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer | Q58862199 | ||
| Allelic loss of chromosome 18q and prognosis in colorectal cancer | Q72024722 | ||
| Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability | Q72127255 | ||
| P433 | issue | 5211 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | DNA mismatch repair | Q2984243 |
| P1104 | number of pages | 3 | |
| P304 | page(s) | 738-740 | |
| P577 | publication date | 1995-05-01 | |
| 1995-05-05 | |||
| P1433 | published in | Science | Q192864 |
| P1476 | title | Mismatch repair deficiency in phenotypically normal human cells | |
| Mismatch Repair Deficiency in Phenotypically Normal Human Cells | |||
| P478 | volume | 268 |
| Q92974648 | A good start of immunotherapy in esophageal cancer |
| Q46987276 | A homozygous PMS2 founder mutation with an attenuated constitutional mismatch repair deficiency phenotype |
| Q73777232 | A human compound heterozygote for two MLH1 missense mutations |
| Q33772742 | A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype |
| Q34133568 | Ageing and the mismatch repair system |
| Q33787464 | Aging, DNA methylation and cancer |
| Q40557856 | Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines |
| Q41376773 | An update of HNPCC (Lynch syndrome). |
| Q40801508 | Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndrome |
| Q40440563 | Appropriate Partners Make Good Matches |
| Q36309767 | Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection |
| Q33513323 | Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeast |
| Q34283911 | Base excision repair in a network of defence and tolerance |
| Q41971956 | Biological effects of simple changes in functionality on rhodium metalloinsertors. |
| Q35911097 | Cancer epigenetics takes center stage. |
| Q41561840 | Cell aging in vivo and in vitro |
| Q42275671 | Colonic epithelial cell proliferation in hereditary non-polyposis colorectal cancer |
| Q53977080 | Colorectal carcinogenesis: from chromosomal evolution pathways to molecular pathogenesis. |
| Q35097421 | Colorectal pretumor progression before and after loss of DNA mismatch repair |
| Q33677624 | Complex genetic predisposition to cancer in an extended HNPCC family with an ancestral hMLH1 mutation. |
| Q30666960 | Consistent loss of heterozygosity at 14Q32 in lymphoid blast crisis of chronic myeloid leukemia |
| Q52643527 | Current status of immunotherapy and immune biomarkers in gastro-esophageal cancers. |
| Q40513970 | DNA methyltransferase Dnmt1 and mismatch repair |
| Q41561505 | DNA mismatch repair gene mutations in human cancer |
| Q52893411 | DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load. |
| Q41536289 | DNA mismatch repair in mammals: role in disease and meiosis |
| Q41854868 | DNA polymerase beta: effects of gapped DNA substrates on dNTP specificity, fidelity, processivity and conformational changes |
| Q41264767 | DNA repair and colorectal cancer |
| Q28295863 | DNA replication fidelity and cancer |
| Q40939179 | DNA-mismatch repair. The intricacies of eukaryotic spell-checking |
| Q39111119 | Detection of DNA mismatch repair proteins in fresh human blood lymphocytes--towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening |
| Q24685020 | Digital PCR |
| Q36570897 | Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers |
| Q35773908 | Effects of mutation and growth rates on patterns of microsatellite instability |
| Q22248073 | Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2 |
| Q36095615 | Emergentism as a default: cancer as a problem of tissue organization |
| Q35747961 | Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability |
| Q33898040 | Evidence for a recessive inheritance of Turcot's syndrome caused by compound heterozygous mutations within the PMS2 gene |
| Q34420082 | Evidence for an hMSH3 defect in familial hamartomatous polyps |
| Q36141256 | Extracolonic features of familial adenomatous polyposis in patients with sporadic colorectal cancer |
| Q35351447 | Folate depletion impairs DNA excision repair in the colon of the rat. |
| Q33951115 | Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase. |
| Q33791245 | Frameshift mutation, microsatellites and mismatch repair |
| Q35840995 | Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas |
| Q36570003 | Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations |
| Q34636941 | Future research directions for evaluating human genetic and cancer risk from environmental exposures |
| Q35016050 | Genetic and environmental factors in cancer and neurodegenerative diseases |
| Q31464606 | Genetic predisposition and somatic diversification in tumor development and progression |
| Q24670186 | Genetic reconstruction of individual colorectal tumor histories |
| Q36104710 | Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing |
| Q73167197 | Hereditary non-polyposis colorectal cancer associated with disseminated superficial porokeratosis. Microsatellite instability in skin tumours |
| Q41045332 | Hereditary nonpolyposis colorectal cancer: review of clinical, molecular genetics, and counseling aspects |
| Q96302702 | Histology-agnostic drug development - considering issues beyond the tissue |
| Q36812749 | Human postmeiotic segregation 2 exhibits biased repair at tetranucleotide microsatellite sequences |
| Q34603856 | Hypermutability in carcinogenesis |
| Q36622540 | Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer |
| Q42560294 | Immunology and the Lynch syndrome |
| Q28069873 | Immunotherapy for Gastroesophageal Cancer |
| Q73827681 | Impact of age on hypermutation of immunoglobulin variable genes in humans |
| Q53433415 | Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes. |
| Q34155290 | In vivo and in vitro studies of immunoglobulin gene somatic hypermutation |
| Q79078009 | In vivo somatic microsatellite mutations identified in non-malignant human tissue |
| Q28283091 | Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype |
| Q28505917 | Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein |
| Q34012877 | Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast |
| Q28131788 | Lessons from hereditary colorectal cancer |
| Q57882330 | Low levels of microsatellite instability characterize MLH1 and MSH2 HNPCC carriers before tumor diagnosis |
| Q36246487 | Lynch syndrome genes |
| Q28508486 | MSH2 deficient mice are viable and susceptible to lymphoid tumours |
| Q34614229 | Maternal effect for DNA mismatch repair in the mouse. |
| Q36642236 | Mature microsatellites: mechanisms underlying dinucleotide microsatellite mutational biases in human cells |
| Q34636932 | Measurement of DNA repair deficiency in workers exposed to benzene |
| Q28510650 | Meiotic pachytene arrest in MLH1-deficient mice |
| Q34770573 | Methylation reveals a niche: stem cell succession in human colon crypts |
| Q37301411 | Microsatellite alterations in phenotypically normal esophageal squamous epithelium and metaplasia-dysplasia-adenocarcinoma sequence |
| Q34723085 | Microsatellite instability and its relevance to cutaneous tumorigenesis |
| Q38471628 | Microsatellite instability and loss of heterozygosity at DNA mismatch repair gene loci occurs during hepatic carcinogenesis |
| Q35300524 | Microsatellite instability and loss of heterozygosity in human pterygia. |
| Q55478796 | Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas. |
| Q37388438 | Microsatellite instability in childhood rhabdomyosarcoma is locus specific and correlates with fractional allelic loss |
| Q36135111 | Microsatellite instability in early sporadic breast cancer. |
| Q36529711 | Microsatellite instability in the peripheral blood leukocytes of HNPCC patients |
| Q40483766 | Microsatellite instability. Shifting concepts in tumorigenesis |
| Q77525944 | Microsatellite mutations in spontaneously aborted embryos |
| Q24545497 | Mini- and microsatellites |
| Q41082110 | Mismatch repair defects and O6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells |
| Q51116841 | Mismatch repair deficient-crypts in non-neoplastic colonic mucosa in Lynch syndrome: insights from an illustrative case. |
| Q35225280 | Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters |
| Q28271480 | Mismatch repair: mechanisms and relationship to cancer susceptibility |
| Q60958385 | Molecular and Computational Methods for the Detection of Microsatellite Instability in Cancer |
| Q41686589 | Molecular biology of colorectal cancer |
| Q78167044 | Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum |
| Q36325598 | Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation |
| Q40762457 | Mutation frequency in coding and non-coding repeat sequences in mismatch repair deficient cells derived from normal human tissue |
| Q28592583 | Mutation in the mismatch repair gene Msh6 causes cancer susceptibility |
| Q71970804 | Mutations in MLH1 are more frequent than in MSH2 in sporadic colorectal cancers with microsatellite instability |
| Q28235642 | Mutations predisposing to hereditary nonpolyposis colorectal cancer |
| Q41099814 | Mutator genes and mosaicism in colorectal cancer |
| Q38301022 | Novel biallelic mutations in MSH6 and PMS2 genes: gene conversion as a likely cause of PMS2 gene inactivation. |
| Q43004039 | PMS2 mutations in childhood cancer |
| Q41855884 | PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper |
| Q45878491 | Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer |
| Q84058811 | Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study |
| Q38293314 | Proficient mismatch repair protein expression in Hodgkin and Reed Sternberg cells |
| Q77899578 | Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers |
| Q53499960 | Prognostic value of microsatellite instability determined by immunohistochemical staining of hMSH2 and hMSH6 in urothelial carcinoma of the bladder. |
| Q77333680 | Radiation induced chromosomal instability in human T-lymphocytes |
| Q24548000 | Rates of spontaneous mutation |
| Q34827304 | Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease |
| Q73501769 | Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation |
| Q41194166 | Risk estimation from somatic mutation assays. |
| Q41029452 | Search for chromosome instability in lymphocytes with germ-line mutations in DNA mismatch repair genes |
| Q45400063 | Simple detection of germline microsatellite instability for diagnosis of constitutional mismatch repair cancer syndrome |
| Q33844435 | Somatic mutations and aging: a re-evaluation |
| Q34616153 | Stability of an inverted repeat in a human fibrosarcoma cell |
| Q28507252 | Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers |
| Q34235210 | Talking tumours: histories from sequences |
| Q36936869 | The cellular, developmental and population-genetic determinants of mutation-rate evolution |
| Q90402575 | The evolving immunotherapeutic landscape in advanced oesophagogastric cancer |
| Q41194136 | The genotype of the human cancer cell: implications for risk analysis. |
| Q41438677 | The natural somatic mutation frequency and human carcinogenesis. |
| Q33923770 | The potential influence of radiation-induced microenvironments in neoplastic progression |
| Q33522197 | Ultradeep sequencing of a human ultraconserved region reveals somatic and constitutional genomic instability |
| Q24621737 | Unbalanced replication as a major source of genetic instability in cancer cells |
| Q53414161 | [Explanation of enigmas of the Lynch syndrome thanks to a new carcinogenesis model characterized by an unorthodox initiation process]. |
| Q27935389 | exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair |
| Q53372462 | hMLH1 and hMSH2 somatic inactivation mechanisms in sporadic colorectal cancer patients. |
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