A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype

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A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.18.3.1635
P932PMC publication ID108878
P698PubMed publication ID9488480

P50authorBert VogelsteinQ827502
Kenneth W. KinzlerQ28031580
P2093author name stringN C Nicolaides
P Modrich
S J Littman
P2860cites workMutations of two PMS homologues in hereditary nonpolyposis colon cancerQ24318484
Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb geneQ24595119
Mutation of a mutL homolog in hereditary colon cancerQ28114939
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancerQ28256988
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancerQ28257360
Molecular cloning of the N-terminus of GTBPQ28292000
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor CellsQ28292781
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cellsQ28292790
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancerQ28294774
Meiotic pachytene arrest in MLH1-deficient miceQ28510650
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repairQ29618879
A versatile in vivo and in vitro eukaryotic expression vector for protein engineeringQ29620181
Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell linesQ33720790
Genomic organization of the human PMS2 gene family.Q34373629
Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping geneQ34385102
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
The molecular basis of Turcot's syndromeQ34662365
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutationsQ36570003
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosisQ38293261
The Jun family members, c-Jun and JunD, transactivate the human c-myb promoter via an Ap1-like element.Q38325809
Mismatch repair, genetic stability, and cancerQ40556409
Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell lineQ41174585
Cancer of the microsatellite mutator phenotype.Q41263775
Mismatch Repair Deficiency in Phenotypically Normal Human CellsQ41347026
Hypermutability and mismatch repair deficiency in RER+ tumor cellsQ41508298
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Mispair specificity of methyl-directed DNA mismatch correction in vitroQ44909730
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancerQ48084125
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patientsQ57570041
Mismatch repair and cancerQ57956407
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
P304page(s)1635-1641
P577publication date1998-03-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleA naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype
P478volume18

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cites work (P2860)
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Q36835972Constitutive deficiency in DNA mismatch repair
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Q34568596DNA mismatch repair defects: role in colorectal carcinogenesis
Q28478209Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids
Q77753605Eukaryotic mismatch repair: an update
Q33898040Evidence for a recessive inheritance of Turcot's syndrome caused by compound heterozygous mutations within the PMS2 gene
Q57204279Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice
Q36641429Extensive molecular screening for hereditary non-polyposis colorectal cancer
Q38755812Functional and physical interaction between the mismatch repair and FA-BRCA pathways
Q27929951Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.
Q35069957Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoprotein
Q35663759Gene expression analysis of tumor spheroids reveals a role for suppressed DNA mismatch repair in multicellular resistance to alkylating agents
Q28214754Genetic instability in human mismatch repair deficient cancers
Q35930688Genetic predisposition to colorectal cancer
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Q93493049HNPCC (Lynch Syndrome): Differential Diagnosis, Molecular Genetics and Management - a Review
Q60934518Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer
Q33234976Human antibodies for immunotherapy development generated via a human B cell hybridoma technology
Q40947848Identification of new tumor suppressor genes based on in vivo functional inactivation of a candidate gene
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Q49111534Low-level microsatellite instability phenotype in sporadic glioblastoma multiforme
Q22009114MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1
Q22010995MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability
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Q36529711Microsatellite instability in the peripheral blood leukocytes of HNPCC patients
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Q33230453Morphogenics as a tool for target discovery and drug development
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Q38874456NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair
Q61811779New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization
Q33909895Novel PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndrome
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Q37444790Protein and genome evolution in Mammalian cells for biotechnology applications
Q39608661Rapid generation of rice mutants via the dominant negative suppression of the mismatch repair protein OsPMS1.
Q40969083Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system
Q27938377Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination
Q34786141The "comparative growth assay": examining the interplay of anti-cancer agents with cells carrying single gene alterations
Q40222264The E705K mutation in hPMS2 exerts recessive, not dominant, effects on mismatch repair
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Q36447028The hMSH2(M688R) Lynch syndrome mutation may function as a dominant negative
Q24621737Unbalanced replication as a major source of genetic instability in cancer cells
Q49043239Yeast mutator phenotype enforced by Arabidopsis PMS1 expression

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