Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

scientific article (publication date: March 2003)

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.1060603
P3181OpenCitations bibliographic resource ID667226
P932PMC publication ID196005
P698PubMed publication ID12629043
P5875ResearchGate publication ID10863319

P50authorNadine KolasQ30303526
P2093author name stringThomas A Kunkel
Richard D Kolodner
Tchaiko Parris
Winfried Edelmann
Edmund Wong
Michael F Kane
Alan B Clark
Robert Russell
Paula E Cohen
Burkhard Kneitz
Harry Hou
Dan J Mazur
Kaichun Wei
Guohze Yang
P2860cites workHuman exonuclease I interacts with the mismatch repair protein hMSH2Q22004013
The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesQ22010967
The interaction of DNA mismatch repair proteins with human exonuclease IQ24291370
Human exonuclease I is required for 5' and 3' mismatch repairQ24292224
Molecular interactions of human Exo1 with DNAQ24292290
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female miceQ24606421
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repairQ27935389
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correctionQ27939611
Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiaeQ28140402
Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC formsQ28190757
EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancerQ28202143
Biochemistry and genetics of eukaryotic mismatch repairQ28282377
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing overQ28282791
Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombinationQ28289308
Mammalian MutS homologue 5 is required for chromosome pairing in meiosisQ28295022
Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activityQ28507875
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repairQ28508905
Meiotic pachytene arrest in MLH1-deficient miceQ28510650
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppressionQ28513250
Expression specificity of the mouse exonuclease 1 (mExo1) geneQ28585040
Mouse models for hereditary nonpolyposis colorectal cancerQ28585761
Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progressQ28586542
Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant miceQ28589732
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient miceQ28593189
Meiotic arrest and aneuploidy in MLH3-deficient miceQ28593875
Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalphaQ28610863
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homologQ29618405
Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiaeQ33933718
The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiaeQ33957467
Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutationsQ33961252
Destabilization of simple repetitive DNA sequences by transcription in yeast.Q33967667
Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formationQ34157868
Deficient DNA mismatch repair: a common etiologic factor for colon cancerQ34189020
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
Functional overlap in mismatch repair by human MSH3 and MSH6.Q34603929
EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiaeQ34609730
A DNA polymerase epsilon mutant that specifically causes +1 frameshift mutations within homonucleotide runs in yeastQ34610131
Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiaeQ34611088
Differential suppression of DNA repair deficiencies of Yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase).Q34614221
In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repairQ36235057
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitroQ36568265
Mechanisms and biological effects of mismatch repairQ37041860
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosisQ38293261
Bidirectional excision in methyl-directed mismatch repairQ38318540
Methyl-directed mismatch repair is bidirectionalQ38318556
Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplexQ38337751
MutS and MutL activate DNA helicase II in a mismatch-dependent mannerQ38337755
Saccharomyces cerevisiae exonuclease-1 plays a role in UV resistance that is distinct from nucleotide excision repairQ39724404
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutantsQ39860143
The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repairQ41396267
A 5'-3' exonuclease from Saccharomyces cerevisiae is required for in vitro recombination between linear DNA molecules with overlapping homologyQ42151362
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosisQ47858327
A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe.Q53926783
A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.Q53963518
Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal CancerQ61946741
EXO1 and MSH4 differentially affect crossing-over and segregationQ73899517
Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repairQ74064844
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectDNA mismatch repairQ2984243
P304page(s)603-14
P577publication date2003-03-01
P1433published inGenes & DevelopmentQ1524533
P1476titleInactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
P478volume17

Reverse relations

cites work (P2860)
Q3558318114-3-3 proteins restrain the Exo1 nuclease to prevent overresection.
Q51769143A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging.
Q24298110A defined human system that supports bidirectional mismatch-provoked excision
Q36749550A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.
Q36540457A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair
Q37181822A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair
Q36457060ATR-dependent pathways control hEXO1 stability in response to stalled forks.
Q35690218Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
Q36954874Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions
Q50671986Age-associated alteration of gene expression patterns in mouse oocytes.
Q28513971Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
Q33822488An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents
Q47445150Analysis of factors decreasing testis weight in MRL mice
Q33247666Analysis of the excision step in human DNA mismatch repair
Q37699397Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma
Q33791321Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1.
Q33604620Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates
Q46726051Bound nucleotide controls the endonuclease activity of mismatch repair enzyme MutL.
Q28534478Breast tumors with elevated expression of 1q candidate genes confer poor clinical outcome and sensitivity to Ras/PI3K inhibition
Q28115810CSB-PGBD3 Mutations Cause Premature Ovarian Failure
Q45129820Cadmium inhibits the functions of eukaryotic MutS complexes.
Q27026386Causal link between microsatellite instability and hMRE11 dysfunction in human cancers
Q85228405Characterization of C- and N-terminal domains of Aquifex aeolicus MutL endonuclease: N-terminal domain stimulates the endonuclease activity of C-terminal domain in a zinc-dependent manner
Q37072156Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair
Q34411080Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae
Q57784307Coordinating Multi-Protein Mismatch Repair by Managing Diffusion Mechanics on the DNA
Q33703015CtIP-mediated resection is essential for viability and can operate independently of BRCA1.
Q36884849DNA Mismatch Repair Interacts with CAF-1- and ASF1A-H3-H4-dependent Histone (H3-H4)2 Tetramer Deposition
Q38036830DNA damage checkpoints in stem cells, ageing and cancer.
Q34814254DNA mismatch repair and infertility
Q28291067DNA mismatch repair in eukaryotes and bacteria
Q24647002DNA mismatch repair: molecular mechanism, cancer, and ageing
Q52605096DNA repair and cell cycle checkpoint defects in a mouse model of 'BRCAness' are partially rescued by 53BP1 deletion.
Q35020482DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas
Q36487307DNA-damage repair; the good, the bad, and the ugly
Q52720061Deoxyribonucleic Acid Damage and Repair: Capitalizing on Our Understanding of the Mechanisms of Maintaining Genomic Integrity for Therapeutic Purposes.
Q51039462Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.
Q50666210Developmental regulation and in vitro culture effects on expression of DNA repair and cell cycle checkpoint control genes in rhesus monkey oocytes and embryos.
Q44761854Differential requirement for proliferating cell nuclear antigen in 5' and 3' nick-directed excision in human mismatch repair
Q33529100Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA
Q36670109Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis
Q47070570DmGEN shows a flap endonuclease activity, cleaving the blocked-flap structure and model replication fork
Q28534756Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway
Q97073533EXO1 Plays a Carcinogenic Role in Hepatocellular Carcinoma and is related to the regulation of FOXP3
Q36002464EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele
Q48587042EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells
Q37964747Emerging evidence for the role of genomic instability in male factor infertility
Q36764079Endonuclease activities of MutLα and its homologs in DNA mismatch repair
Q33711830Eukaryotic Mismatch Repair in Relation to DNA Replication
Q28551519Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites
Q36115776Evidence that the DNA mismatch repair system removes 1-nucleotide Okazaki fragment flaps
Q38974172Exo1 independent DNA mismatch repair involves multiple compensatory nucleases
Q35564759Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zeta
Q36421123Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents
Q38919536Exonuclease 1 and its versatile roles in DNA repair
Q33573646Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells
Q28261787Exonuclease 1-dependent and independent mismatch repair
Q33297433Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice
Q42043478Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends
Q35663520Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis
Q36046488Genetic risk of lung cancer associated with a single nucleotide polymorphism from EXO1: a meta analysis.
Q33631793Genome-wide identification of CBX2 targets: insights in the human sex development network
Q47766916Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro
Q35170755Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation
Q33224078Human mismatch repair: reconstitution of a nick-directed bidirectional reaction
Q33791326Hydrolytic function of Exo1 in mammalian mismatch repair.
Q90647988Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners
Q64376748Identification of a panel of MYC and Tip60 co-regulated genes functioning primarily in cell cycle and DNA replication
Q36741556Identification of regulatory factor X as a novel mismatch repair stimulatory factor
Q28074585Impact of DNA mismatch repair system alterations on human fertility and related treatments
Q39991083Inhibition of the 5' to 3' exonuclease activity of hEXO1 by 8-oxoguanine
Q52769433Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Q47135454Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae.
Q37215365Involvement of Exo1b in DNA damage-induced apoptosis
Q35792957Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias
Q33369076MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis
Q48256770Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes.
Q37590653Male infertility: a risk factor for testicular cancer
Q35585478Male reproductive cancers and infertility: a mutual relationship
Q35875365Male reproductive health and prostate cancer risk
Q36991032Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes
Q26740310Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer
Q51793302Measuring strand discontinuity-directed mismatch repair in yeast Saccharomyces cerevisiae by cell-free nuclear extracts.
Q24300483Mechanism of 5'-directed excision in human mismatch repair
Q36547669Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching
Q28262719Mechanisms and functions of DNA mismatch repair
Q36564560Mechanisms in eukaryotic mismatch repair
Q38618828Meiotic Recombination: The Essence of Heredity
Q38153644Meiotic recombination in mammals: localization and regulation
Q35910256Meiotic recombination intermediates and mismatch repair proteins
Q34248904Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Q44447213Mismatch repair in human nuclear extracts: effects of internal DNA-hairpin structures between mismatches and excision-initiation nicks on mismatch correction and mismatch-provoked excision
Q34773522Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining
Q57058967Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure
Q24630140Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems
Q37084734Mouse models in male fertility research
Q57472222MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective
Q28084645New insights into the mechanism of DNA mismatch repair
Q35829272Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)
Q26822478Nucleases in homologous recombination as targets for cancer therapy
Q37011985Nucleosome dynamics regulates DNA processing
Q37037194O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo
Q35893147Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex
Q24632622Okazaki fragment maturation: nucleases take centre stage
Q33961620PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.
Q24606670PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
Q36258155PHF11 promotes DSB resection, ATR signaling, and HR.
Q34068165PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
Q33519468Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
Q34488378Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.
Q21133598Predicting the proteins of Angomonas deanei, Strigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family
Q64132285Quantitative trait loci analysis of heat stress resistance of spermatocytes in the MRL/MpJ mouse
Q36972154Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
Q33556873Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins
Q37319600Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins
Q34016965Repair of endogenous DNA base lesions modulate lifespan in mice
Q33317311Rice exonuclease-1 homologue, OsEXO1, that interacts with DNA polymerase lambda and RPA subunit proteins, is involved in cell proliferation
Q37058602Sharpening the ends for repair: mechanisms and regulation of DNA resection
Q42373192Significant association of the EXO1 rs851797 polymorphism with clinical outcome of ovarian cancer.
Q35027619Single molecule studies of DNA mismatch repair
Q35925569Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins
Q26999680Single-molecule views of MutS on mismatched DNA.
Q54430309Somatic mutation of EXO1 gene in gastric and colorectal cancers with microsatellite instability.
Q36521428Structure and function of the components of the human DNA mismatch repair system
Q27667527Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
Q36895121Targeted next-generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families
Q28301386Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions
Q51312086The Major Replicative Histone Chaperone CAF-1 Suppresses the Activity of the DNA Mismatch Repair System in the Cytotoxic Response to a DNA-methylating Agent.
Q52671466The Role of Oncogenic Tyrosine Kinase NPM-ALK in Genomic Instability.
Q37334051The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs
Q36744624The interplay between hMLH1 and hMRE11: role in MMR and the effect of hMLH1 mutations
Q36448284The multifaceted mismatch-repair system
Q34551905The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells
Q53195871The significance of Exonuclease 1 K589E polymorphism on hepatocellular carcinoma susceptibility in the Turkish population: a case-control study.
Q58789945Timing of Expansion of Fragile X Premutation Alleles During Intergenerational Transmission in a Mouse Model of the Fragile X-Related Disorders
Q90211035Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer's Disease Mouse Model
Q54442651Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.
Q27005670Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases
Q55283304Validating the concept of mutational signatures with isogenic cell models.
Q47439130Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice
Q37776339Wot the ‘L—Does MutL do?
Q92458719XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection
Q34166799hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair

Search more.