Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA

scientific article

Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2010PLoSO...5.8908V
P356DOI10.1371/JOURNAL.PONE.0008908
P932PMC publication ID2811187
P698PubMed publication ID20126648
P5875ResearchGate publication ID41401653

P2093author name stringNancy Maizels
Aarthy C Vallur
P2860cites workThe RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesQ22010967
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicasesQ24291390
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activityQ24291787
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkQ24301121
Stimulation of flap endonuclease-1 by the Bloom's syndrome proteinQ24302463
RTEL1 maintains genomic stability by suppressing homologous recombinationQ24309568
Purification of proteins associated with specific genomic LociQ24315634
Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1Q24319085
Prevalence of quadruplexes in the human genomeQ24529051
TERRA: telomeric repeat-containing RNAQ24656014
The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAsQ27930229
Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repairQ27930737
EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiaeQ27933420
Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.Q27936665
Evidence that a RecQ helicase slows senescence by resolving recombining telomeresQ27937469
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome endsQ28116571
The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome proteinQ28155868
Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterilityQ28182219
Flap endonuclease 1: a central component of DNA metabolismQ28266199
A conserved G4 DNA binding domain in RecQ family helicases.Q54469019
G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas.Q55043612
SGS1 is required for telomere elongation in the absence of telomeraseQ61782242
Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegansQ63432949
Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansionQ73626789
The human minisatellites MS1, MS32, MS205 and CEB1 integrated into the yeast genome exhibit different degrees of mitotic instability but are all stabilised by RAD27Q74624838
Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)nQ77353843
The Bloom's syndrome helicase unwinds G4 DNAQ77387768
Dynamic roles for G4 DNA in the biology of eukaryotic cellsQ79405617
Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombinationQ28289308
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repairQ28299185
Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stageQ28509911
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant miceQ28513971
Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like proteinQ28587423
Enzymes and reactions at the eukaryotic DNA replication forkQ28610363
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional miceQ33297433
G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibitionQ34367524
Differential processing of leading- and lagging-strand ends at Saccharomyces cerevisiae telomeres revealed by the absence of Rad27p nucleaseQ34616720
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.Q34729916
EXO1-A multi-tasking eukaryotic nuclease.Q35913244
Immunoglobulin gene diversificationQ36312189
DNA architecture: from G to Z.Q36399170
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regionsQ36499177
Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genesQ36509106
Flap endonuclease 1 contributes to telomere stabilityQ36632697
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stabilityQ36710804
Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repairQ36748151
Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regionsQ36954874
Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcriptionQ37118798
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replicationQ37297007
Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutantsQ38335994
Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stabilityQ38351980
Instability of the human minisatellite CEB1 in rad27Delta and dna2-1 replication-deficient yeast cells.Q39644924
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutantsQ39860143
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tractsQ39922407
Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.Q40078013
Telomerase- and recombination-independent immortalization of budding yeastQ40294605
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.Q40481955
Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNAQ41023029
DNA helicases Sgs1 and BLM promote DNA double-strand break resectionQ42750184
Gene function correlates with potential for G4 DNA formation in the human genomeQ43056206
Stimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding regionQ43690417
The acetylatable lysines of human Fen1 are important for endo- and exonuclease activitiesQ44395811
Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structureQ45173725
FEN1 contributes to telomere stability in ALT-positive tumor cellsQ45794995
Mechanism of tracking and cleavage of adduct-damaged DNA substrates by the mammalian 5'- to 3'-exonuclease/endonuclease RAD2 homologue 1 or flap endonuclease 1.Q49118082
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)e8908
P577publication date2010-01-26
P1433published inPLOS OneQ564954
P1476titleDistinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA
P478volume5

Reverse relations

cites work (P2860)
Q3610087314-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif
Q34121171Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats
Q39204805DNA Replication Origins and Fork Progression at Mammalian Telomeres
Q35742524Exonuclease 1 (EXO1) gene variation and melanoma risk
Q36920133Flap endonuclease 1.
Q39018239Formation and processing of DNA damage substrates for the hNEIL enzymes
Q34343255Kinetics of endogenous mouse FEN1 in base excision repair.
Q28118339Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity
Q36991032Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes
Q35638929RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.
Q35059142Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
Q27667527Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
Q37814480Telomere replication: poised but puzzling
Q34334057Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability

Search more.