The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein

scientific article (publication date: 27 June 2003)

The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M212798200
P698PubMed publication ID12704184

P50authorSudha SharmaQ41653425
P2093author name stringTeresa M Wilson
Joshua A Sommers
Robert M Brosh
Henry C Driscoll
Laura Uzdilla
P2860cites workHuman exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidanceQ22009967
Functional and physical interaction between WRN helicase and human replication protein AQ22010009
The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesQ22010967
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activityQ22254162
The interaction of DNA mismatch repair proteins with human exonuclease IQ24291370
p53 Modulates the exonuclease activity of Werner syndrome proteinQ24291371
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activityQ24291787
Human exonuclease I is required for 5' and 3' mismatch repairQ24292224
The Werner syndrome protein is a DNA helicaseQ24310486
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseasesQ24317166
Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1Q24319085
Mutator phenotype of Werner syndrome is characterized by extensive deletionsQ24609670
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiaeQ27934255
Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrateQ27935216
Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiaeQ28140402
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacityQ28589633
Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1Q28645598
Positional cloning of the Werner's syndrome geneQ29618393
RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotesQ30704734
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrestQ30983796
Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell linesQ33189110
Loss of Werner syndrome protein function promotes aberrant mitotic recombinationQ33943676
Homologous recombination resolution defect in werner syndromeQ34150355
Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicismQ34283406
Roles of the Werner syndrome protein in pathways required for maintenance of genome stabilityQ34519481
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.Q34707698
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitroQ36568265
Stimulation of RTH1 nuclease of the yeast Saccharomyces cerevisiae by replication protein A.Q36863010
The premature ageing syndrome protein, WRN, is a 3'-->5' exonucleaseQ37083237
DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus systemQ39720740
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutantsQ39860143
Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damageQ40840880
Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phaseQ40968297
An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutantsQ41076163
The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repairQ41396267
Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cellsQ41723911
Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.Q53775920
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cellsQ57250868
SGS1 is required for telomere elongation in the absence of telomeraseQ61782242
Altered frequency of initiation sites of DNA replication in Werner's syndrome cellsQ70427873
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblastsQ73311217
Molecular biology. DNA ends ReQ-uire attentionQ73760824
Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonucleaseQ77677868
Biochemical characterization of the DNA substrate specificity of Werner syndrome helicaseQ77948758
Growth characteristics of Werner syndrome cells in vitroQ93667534
Autoradiographic studies of DNA replication in Werner's syndrome cellsQ93667542
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectWerner syndromeQ1154619
P304page(s)23487-23496
P577publication date2003-04-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein
P478volume278

Reverse relations

cites work (P2860)
Q3610087314-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif
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Q33327349Acetylation regulates WRN catalytic activities and affects base excision DNA repair
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