Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae

scientific article (publication date: July 2000)

Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1091/MBC.11.7.2221
P932PMC publication ID14915
P698PubMed publication ID10888664
P5875ResearchGate publication ID12429806

P2093author name stringH Ogawa
H Tsubouchi
P2860cites workCrossover interference is abolished in the absence of a synaptonemal complex proteinQ72790781
The many interfaces of Mre11Q77654630
Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidanceQ22009967
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaksQ24311761
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95Q24323459
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencingQ24533190
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathwaysQ24561996
Meiotic chromosomes: it takes two to tangoQ27930023
A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiaeQ27930541
Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombinationQ27930776
Mutations in Saccharomyces cerevisiae That Block Meiotic Prophase Chromosome Metabolism and Confer Cell Cycle Arrest at Pachytene Identify Two New Meiosis-Specific Genes SAE1 and SAE3Q27931736
Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiaeQ27932896
DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progressionQ27933115
The product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, specifically functions in mitochondriaQ27933751
Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like proteinQ27933995
Zip2, a meiosis-specific protein required for the initiation of chromosome synapsisQ27934770
Characterization of a novel DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, which is a structural homolog of the RAD2 and RAD27 DNA repair genes.Q27935693
Complex formation and functional versatility of Mre11 of budding yeast in recombinationQ27935743
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenanceQ27937328
Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.Q27937499
The transcriptional program of sporulation in budding yeastQ27938344
Identification of new genes required for meiotic recombination in Saccharomyces cerevisiaeQ27938429
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correctionQ27939611
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sitesQ28131597
One-step gene disruption in yeastQ28131598
A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strainsQ28131619
The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interestQ28131694
Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombinationQ28289308
Multiple functions of MutS- and MutL-related heterocomplexesQ28776215
The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiaeQ29465403
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damageQ29614221
Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombinationQ29615272
Sterile host yeasts (SHY): A eukaryotic system of biological containment for recombinant DNA experimentsQ29620758
[12] One-step gene disruption in yeastQ29642800
Sporulation Synchrony of Saccharomyces cerevisiae Grown in Various Carbon SourcesQ33789395
The yeast RAD50 gene encodes a predicted 153-kD protein containing a purine nucleotide-binding domain and two large heptad-repeat regionsQ33955345
XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombinationQ33960085
Evidence for two types of allelic recombination in yeastQ33980168
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenanceQ34411525
Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11.Q34605521
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitroQ36568265
Genetic recombination and commitment to meiosis in SaccharomycesQ37456227
Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiaeQ38308503
The Saccharomyces cerevisiae MER3 gene, encoding a novel helicase-like protein, is required for crossover control in meiosisQ38319411
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosisQ39631261
Cloning and characterisation of the Schizosaccharomyces pombe rad32 gene: a gene required for repair of double strand breaks and recombinationQ40392825
In vivo biochemistry: physical monitoring of recombination induced by site-specific endonucleases.Q40465998
Molecular cloning of the actin gene from yeast Saccharomyces cerevisiaeQ40480837
Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formationQ40653881
Intermediates of recombination during mating type switching in Saccharomyces cerevisiaeQ41203841
Meiotic recombination in yeast: coronation of the double-strand-break repair modelQ41285976
A super new twist on the initiation of meiotic recombinationQ41434983
Tosca: a Drosophila gene encoding a nuclease specifically expressed in the female germline.Q47070291
Telomere maintenance is dependent on activities required for end repair of double-strand breaksQ47946099
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correctionQ48076989
A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.Q53963518
RecA-like recombination proteins in eukaryotes: functions and structures of RAD51 genesQ56937930
Double-strand breaks at an initiation site for meiotic gene conversionQ59068287
Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiaeQ64389209
Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation siteQ64389995
A genetic study of x-ray sensitive mutants in yeastQ69356688
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repairQ71919357
DNA structure-dependent requirements for yeast RAD genes in gene conversionQ72356626
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)2221-33
P577publication date2000-07-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleExo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae
P478volume11

Reverse relations

cites work (P2860)
Q3388654714-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks
Q24299584A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
Q27931208A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.
Q34266467A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy
Q36457060ATR-dependent pathways control hEXO1 stability in response to stalled forks.
Q33855288Alteration of gene conversion tract length and associated crossing over during plasmid gap repair in nuclease-deficient strains of Saccharomyces cerevisiae
Q28513971Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
Q34614513Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.
Q27934521Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae
Q51782566Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination.
Q44267791AtATM is essential for meiosis and the somatic response to DNA damage in plants
Q33726437Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks
Q27930407Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1
Q33791321Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1.
Q33604620Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates
Q38206208Biology of telomeres: lessons from budding yeast
Q35757748Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function
Q48829348Caenorhabditis elegans Ce-rdh-1/rad-51 functions after double-strand break formation of meiotic recombination
Q39859714Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III
Q24302011Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA
Q27934255Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae
Q34816808Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
Q34569381Competing crossover pathways act during meiosis in Saccharomyces cerevisiae
Q35161764Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres
Q38351980Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability
Q37224128Ctp1 and Exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination
Q37361939DNA double-strand break processing: the beginning of the end.
Q34612802DNA end resection--unraveling the tail
Q24654725DNA end resection: many nucleases make light work
Q42280794DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase
Q36429457DNA repair protein: endo-exonuclease as a new frontier in cancer therapy
Q34611088Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiae
Q33945750Delineation of WRN helicase function with EXO1 in the replicational stress response
Q34614221Differential suppression of DNA repair deficiencies of Yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase).
Q27931609Din7 and Mhr1 expression levels regulate double-strand-break-induced replication and recombination of mtDNA at ori5 in yeast
Q37226108Dna2 is involved in CA strand resection and nascent lagging strand completion at native yeast telomeres
Q27931988Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks
Q36002464EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele
Q42426732EXO1 plays a role in generating type I and type II survivors in budding yeast
Q39860143EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants
Q37062471End Resection Initiates Genomic Instability in the Absence of Telomerase
Q33938581End resection at double-strand breaks: mechanism and regulation
Q34559710End-processing during non-homologous end-joining: a role for exonuclease 1
Q33222159Evidence of meiotic crossover control in Saccharomyces cerevisiae through Mec1-mediated phosphorylation of replication protein A.
Q38335994Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants
Q89533185Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins
Q90292067Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian Cancer
Q38919536Exonuclease 1 and its versatile roles in DNA repair
Q28261787Exonuclease 1-dependent and independent mismatch repair
Q42268671Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast
Q42043478Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends
Q27935172Functional and genetic analysis of the Saccharomyces cerevisiae RNC1/TRM2: evidences for its involvement in DNA double-strand break repair
Q47246612Genetic Evidence for Roles of Yeast Mitotic Cyclins at Single-Stranded Gaps Created by DNA Replication
Q33404063Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes
Q40975957Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast.
Q28185113Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability
Q24291378HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes
Q38358603Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity
Q28182219Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
Q43993843Inactivation of Mre11 does not affect VSG gene duplication mediated by homologous recombination in Trypanosoma brucei.
Q37215365Involvement of Exo1b in DNA damage-induced apoptosis
Q34211299Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2
Q40380499Laboratory variability does not preclude identification of biological functions impacted by hydroxyurea
Q37622790MRN and the race to the break
Q36991032Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes
Q35954448Mec1p associates with functionally compromised telomeres
Q29618789Mechanism and control of meiotic recombination initiation
Q37118849Mechanism and regulation of DNA end resection in eukaryotes
Q37774547Mechanisms and regulation of DNA end resection
Q26864428Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae
Q38618828Meiotic Recombination: The Essence of Heredity
Q35910256Meiotic recombination intermediates and mismatch repair proteins
Q24292290Molecular interactions of human Exo1 with DNA
Q40078013Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.
Q36916670Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
Q27012760Multiple cellular mechanisms prevent chromosomal rearrangements involving repetitive DNA
Q64065581Noncanonical Contributions of MutLγ to VDE-Initiated Crossovers During Meiosis
Q58128099Novel Sensitive Fluorometric Determination of Exonuclease I Using Polydopamine Nanospheres
Q35661319Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability
Q37011985Nucleosome dynamics regulates DNA processing
Q34613942Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism
Q33519468Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
Q34488378Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.
Q37058652Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR).
Q36779483Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins
Q27939123Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases
Q38214443Quality control of homologous recombination
Q24301788RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination
Q36542150Rad50S alleles of the Mre11 complex: questions answered and questions raised
Q34661452RecQ helicase and RecJ nuclease provide complementary functions to resect DNA for homologous recombination
Q34108141Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans.
Q48015207Recombination at subtelomeres is regulated by physical distance, double-strand break resection and chromatin status.
Q60920607Replication stress-induced Exo1 phosphorylation is mediated by Rad53/Pph3 and Exo1 nuclear localization is controlled by 14-3-3 proteins
Q40292461Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.
Q33317311Rice exonuclease-1 homologue, OsEXO1, that interacts with DNA polymerase lambda and RPA subunit proteins, is involved in cell proliferation
Q29618204Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair
Q34643127Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex
Q60927678Role of the Mre11 Complex in Preserving Genome Integrity
Q34644404Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.
Q36540776Roles for mismatch repair family proteins in promoting meiotic crossing over
Q46127945Saccharomyces cerevisiae Mer3 helicase stimulates 3'-5' heteroduplex extension by Rad51; implications for crossover control in meiotic recombination
Q42408271Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
Q35945630Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining
Q33667306Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats
Q27931367Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.
Q29615269Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
Q37058602Sharpening the ends for repair: mechanisms and regulation of DNA resection
Q37971853Similarities and differences between "uncapped" telomeres and DNA double-strand breaks.
Q29618612Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast
Q27631960Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
Q38235791Structural studies of DNA end detection and resection in homologous recombination
Q36189334Sumoylation regulates EXO1 stability and processing of DNA damage
Q27933098Supercomplex formation between Mlh1-Mlh3 and Sgs1-Top3 heterocomplexes in meiotic yeast cells
Q27936152Synergistic effect of TRM2/RNC1 and EXO1 in DNA double-strand break repair in Saccharomyces cerevisiae
Q34463536Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair
Q28550291Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks
Q40294605Telomerase- and recombination-independent immortalization of budding yeast
Q28301386Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions
Q27932618The MER3 DNA helicase catalyzes the unwinding of holliday junctions
Q30990610The MER3 helicase involved in meiotic crossing over is stimulated by single-stranded DNA-binding proteins and unwinds DNA in the 3' to 5' direction.
Q27937197The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair
Q37574070The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks
Q40950715The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1.
Q27931846The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution
Q28155868The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein
Q33822400The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.
Q36900911The multiple roles of the Mre11 complex for meiotic recombination
Q36483126The role of DNA exonucleases in protecting genome stability and their impact on ageing.
Q34016542The role of Exo1p exonuclease in DNA end resection to generate gene conversion tracts in Saccharomyces cerevisiae
Q41893760To trim or not to trim: progression and control of DSB end resection
Q36740600Unique and important consequences of RECQ1 deficiency in mammalian cells
Q36595565Unique and overlapping functions of the Exo1, Mre11 and Pso2 nucleases in DNA repair
Q42162427VDE-initiated intein homing in Saccharomyces cerevisiae proceeds in a meiotic recombination-like manner.
Q78025737Wild-type levels of Spo11-induced DSBs are required for normal single-strand resection during meiosis
Q27935389exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair

Search more.