Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.

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Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID1462004
P698PubMed publication ID11901110

P50authorJuan Lucas ArguesoQ55457091
P2093author name stringDaniel Smith
Eric Alani
Sumeet Sarin
James Yi
Marc Waase
P2860cites workThe interaction of DNA mismatch repair proteins with human exonuclease IQ24291370
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1Q24555123
Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repairQ27617873
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agentQ27736012
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesisQ27766073
Mammalian Ras interacts directly with the serine/threonine kinase RafQ27860833
Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.Q27929951
Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiaeQ27930781
Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functionsQ27932283
Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeastQ27934236
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repairQ27935389
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Repair of specific base pair mismatches formed during meiotic recombination in the yeast Saccharomyces cerevisiaeQ43182601
Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutantsQ46691965
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correctionQ48076989
A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.Q53963518
Intermediates of Yeast Meiotic Recombination Contain Heteroduplex DNAQ58486283
Double-strand breaks at an initiation site for meiotic gene conversionQ59068287
An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiaeQ59090272
Initiation of methyl-directed mismatch repairQ64389906
Mismatch-specific post-meiotic segregation frequency in yeast suggests a heteroduplex recombination intermediateQ69893763
Origins of gene conversion and reciprocal exchange in AscobolusQ70974126
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repairQ71919357
EXO1 and MSH4 differentially affect crossing-over and segregationQ73899517
Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repairQ74064844
The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activityQ77765360
Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repairQ27938608
Eukaryotic DNA mismatch repairQ27939116
ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexesQ27939412
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correctionQ27939611
Multifunctional yeast high-copy-number shuttle vectorsQ28131605
Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288CQ28131625
Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiaeQ28140402
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyraseQ28170377
The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repairQ28186022
Differential timing and control of noncrossover and crossover recombination during meiosisQ28207440
Pathway correcting DNA replication errors in Saccharomyces cerevisiaeQ28263175
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairQ28610858
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repairQ29618879
Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD.Q32108861
Defending genome integrity during DNA replication: a proposed role for RecQ family helicasesQ33666386
GHKL, an emergent ATPase/kinase superfamilyQ33818817
Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiaeQ33933718
Meiotic recombination frequencies are affected by nutritional states in SaccharomycescerevisiaeQ33952006
The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiaeQ33957467
Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiaeQ33959781
Biochemical Mutants in the Smut Fungus Ustilago Maydis.Q33975198
Crystal structure of an N-terminal fragment of the DNA gyrase B protein.Q34493198
The conversion gradient at HIS4 of Saccharomyces cerevisiae. I. Heteroduplex rejection and restoration of Mendelian segregationQ34607928
EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiaeQ34609730
Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiaeQ34611088
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitroQ36568265
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutationsQ36570003
The Saccharomyces cerevisiae ARG4 initiator of meiotic gene conversion and its associated double-strand DNA breaks can be inhibited by transcriptional interferenceQ37349528
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repairQ39449001
Macromolecule synthesis and breakdown in relation to sporulation and meiosis in yeast.Q40089491
Meiotic Gene Conversion: A Signal of the Basic Recombination Event in YeastQ40613842
Instability of simple sequence DNA in Saccharomyces cerevisiaeQ40655124
Synthetic enhancement in gene interaction: a genetic tool come of age.Q40796844
Molecular matchmakersQ40885529
Protein degradation, meiosis and sporulation in proteinase-deficient mutants of Saccharomyces cerevisiaeQ42178696
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
DNA mismatch repairQ2984243
P1104number of pages13
P304page(s)909-921
P577publication date2002-03-01
P1433published inGeneticsQ3100575
P1476titleAnalysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over
P478volume160

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cites work (P2860)
Q42410408A Two-Pathway Analysis of Meiotic Crossing Over and Gene Conversion in Saccharomyces cerevisiae
Q64928626A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I.
Q34616364Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes
Q37110421Cell-cycle and DNA damage regulation of the DNA mismatch repair protein Msh2 occurs at the transcriptional and post-transcriptional level.
Q37734351Conditional DNA repair mutants enable highly precise genome engineering
Q33754229DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1
Q31119964Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain
Q30584795Inferring the Brassica rapa Interactome Using Protein-Protein Interaction Data from Arabidopsis thaliana.
Q35684970Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism
Q36540568Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer
Q33758490Mutants with temperature-sensitive defects in the Escherichia coli mismatch repair system: sensitivity to mispairs generated in vivo
Q34480201Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair
Q27938184Role of proliferating cell nuclear antigen interactions in the mismatch repair-dependent processing of mitotic and meiotic recombination intermediates in yeast
Q36540776Roles for mismatch repair family proteins in promoting meiotic crossing over
Q28242820Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae.
Q34463536Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair
Q33615733The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans.
Q27932484The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains
Q36287848Using crossover breakpoints in recombinant inbred lines to identify quantitative trait loci controlling the global recombination frequency
Q42352313mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.

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