Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast

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Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-9822(00)00314-6
P698PubMed publication ID10679328
P5875ResearchGate publication ID12636770

P2093author name stringS Jinks-Robertson
B D Harfe
B K Minesinger
P2860cites workRemoval of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiaeQ33865368
Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteinsQ36568343
Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.Q36568353
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genesQ40022200
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes.Q54108643
Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stabilityQ71081409
Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridizationQ24657378
Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complexQ27932428
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
Eukaryotic DNA mismatch repairQ27939116
ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexesQ27939412
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correctionQ27939611
New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiaeQ28131599
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
The distribution of the numbers of mutants in bacterial populationsQ29620123
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectMismatch repair protein MLH3 YPL164CQ27547621
Mismatch repair protein MLH2 YLR035CQ27549438
P304page(s)145-8
P577publication date2000-02-10
P1433published inCurrent BiologyQ1144851
P1476titleDiscrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast
P478volume10

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cites work (P2860)
Q36724317A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae
Q36540457A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair
Q27931208A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.
Q24564010ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage
Q35690218Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
Q34616364Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes
Q34614513Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.
Q27934521Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae
Q34443496Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae
Q34926104Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome
Q40806587Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion.
Q28211143DNA mismatch repair and mutation avoidance pathways
Q28291067DNA mismatch repair in eukaryotes and bacteria
Q36453321DNA mismatch repair system. Classical and fresh roles
Q73406613DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q35034387Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast.
Q36371989Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair
Q40895728Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae.
Q34612288Efficient incorporation of large (>2 kb) heterologies into heteroduplex DNA: Pms1/Msh2-dependent and -independent large loop mismatch repair in Saccharomyces cerevisiae
Q33948391Efficient repair of large DNA loops in Saccharomyces cerevisiae
Q36643853Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast
Q35748265Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae.
Q27932384Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast
Q33649978Genetic testing for hereditary colorectal cancer
Q35318165Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1
Q36451916Human mismatch repair protein hMutLα is required to repair short slipped-DNAs of trinucleotide repeats
Q39514722Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry
Q33967139Inactivation of DNA mismatch repair by increased expression of yeast MLH1.
Q33933718Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae
Q39675432Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair
Q34012877Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast
Q34204951Little evidence for involvement of MLH3 in colorectal cancer predisposition
Q38084166Lynch syndrome-associated neoplasms: a discussion on histopathology and immunohistochemistry.
Q50661115MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer.
Q27939603Meiotic recombination involving heterozygous large insertions in Saccharomyces cerevisiae: formation and repair of large, unpaired DNA loops
Q34194518Mismatch repair in correction of replication errors and processing of DNA damage
Q46111533Mismatch repair protein expression and microsatellite instability: a comparison of clear cell sarcoma of soft parts and metastatic melanoma
Q46727121Mismatch repair regulates homologous recombination, but has little influence on antigenic variation, in Trypanosoma brucei
Q37691675Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex
Q35757682Mlh1 deficiency in zebrafish results in male sterility and aneuploid as well as triploid progeny in females.
Q35165645Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae
Q34293069Molecular mechanisms of DNA mismatch repair
Q28084645New insights into the mechanism of DNA mismatch repair
Q34097342Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication
Q33343446Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
Q36090192Oligonucleotide transformation of yeast reveals mismatch repair complexes to be differentially active on DNA replication strands
Q33351867Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae
Q27690911Postreplicative mismatch repair
Q39608661Rapid generation of rice mutants via the dominant negative suppression of the mismatch repair protein OsPMS1.
Q33556873Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins
Q52929756Repair bias of large loop mismatches during recombination in mammalian cells depends on loop length and structure.
Q92634185Resolvases, Dissolvases, and Helicases in Homologous Recombination: Clearing the Road for Chromosome Segregation
Q34619419Role of mismatch repair in the fidelity of RAD51- and RAD59-dependent recombination in Saccharomyces cerevisiae
Q27931230Saccharomyces cerevisiae Msh2-Msh3 acts in repair of base-base mispairs
Q34610604Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae.
Q35027619Single molecule studies of DNA mismatch repair
Q34463536Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair
Q28306188The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctions
Q34895336The effects of mismatch repair and RAD1 genes on interchromosomal crossover recombination in Saccharomyces cerevisiae
Q42828810The large loop repair and mismatch repair pathways of Saccharomyces cerevisiae act on distinct substrates during meiosis
Q36642237The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer
Q52956515Why do mammalian mitochondria possess a mismatch repair activity?
Q42352313mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.

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