Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair

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Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1006722
P932PMC publication ID5448812
P698PubMed publication ID28505149

P50authorCorentin Claeys BouuaertQ47114649
Scott KeeneyQ30093301
P2093author name stringScott Keeney
Corentin Claeys Bouuaert
P2860cites workThe conserved molecular machinery in DNA mismatch repair enzyme structuresQ26770149
Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease siteQ27684073
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correctionQ48076989
Crossing over analysis at pachytene in man.Q50335535
Identification of double Holliday junctions as intermediates in meiotic recombination.Q54599520
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repairQ71919357
Molecular weights of individual proteins correlate with molecular volumes measured by atomic force microscopyQ74028430
The effect of genetic background on the function of Saccharomyces cerevisiae mlh1 alleles that correspond to HNPCC missense mutationsQ79518237
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesisQ27766073
Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.Q27929951
Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein familyQ27930009
Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1Q27930407
A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.Q27931208
The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distributionQ27931846
Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.Q27932379
Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeastQ27932384
Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeastQ27934236
Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosisQ27934346
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimerQ27936605
Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteinsQ27937399
Identification of Holliday junction resolvases from humans and yeastQ27937498
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correctionQ27939611
MSH4 acts in conjunction with MLH1 during mammalian meiosisQ28142773
Differential timing and control of noncrossover and crossover recombination during meiosisQ28207440
The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombinationQ28214583
BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolismQ28264465
Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvaseQ28264475
hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomesQ28276445
Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctionsQ28301386
Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonucleaseQ28305501
The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctionsQ28306188
Single-molecule analysis reveals the kinetics and physiological relevance of MutL-ssDNA bindingQ28476139
Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase IQ28505426
Crossover and noncrossover pathways in mouse meiosisQ28586370
Meiotic arrest and aneuploidy in MLH3-deficient miceQ28593875
The Phyre2 web portal for protein modeling, prediction and analysisQ29616136
An atypical topoisomerase II from Archaea with implications for meiotic recombinationQ29618230
The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombinationQ29618523
Temporal progression of recombination in human malesQ33222301
Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alphaQ33645614
Genetic Analysis of Baker's Yeast Msh4-Msh5 Reveals a Threshold Crossover Level for Meiotic ViabilityQ33701780
Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.Q34142750
Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repairQ34463536
Top3-Rmi1 DNA single-strand decatenase is integral to the formation and resolution of meiotic recombination intermediatesQ34463801
Competing crossover pathways act during meiosis in Saccharomyces cerevisiaeQ34569381
Distribution of crossing over on mouse synaptonemal complexes using immunofluorescent localization of MLH1 protein.Q34606677
MLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiaeQ34617068
The Mus81/Mms4 Endonuclease Acts Independently of Double-Holliday Junction Resolution to Promote a Distinct Subset of Crossovers During Meiosis in Budding YeastQ34617616
Mechanism and regulation of meiotic recombination initiationQ34931212
DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.Q34967180
Exploiting spore-autonomous fluorescent protein expression to quantify meiotic chromosome behaviors in Saccharomyces cerevisiae.Q35297892
The unstructured linker arms of Mlh1-Pms1 are important for interactions with DNA during mismatch repairQ36162012
Mismatch repairQ36283640
Roles for mismatch repair family proteins in promoting meiotic crossing overQ36540776
Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.Q36568353
Distinct functions of MLH3 at recombination hot spots in the mouse.Q36571740
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiaeQ36724317
A DNA-tethered cleavage probe reveals the path for promoter DNA in the yeast preinitiation complexQ36791309
ZMM proteins during meiosis: crossover artists at workQ36900922
A few of our favorite things: Pairing, the bouquet, crossover interference and evolution of meiosis.Q36902036
Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repairQ37592729
Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation.Q37656154
The choice in meiosis - defining the factors that influence crossover or non-crossover formationQ37833845
Endonucleolytic processing of covalent protein-linked DNA double-strand breaksQ38322004
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
Insights from a decade of biophysical studies on MutL: Roles in strand discrimination and mismatch removal.Q38363291
Meiotic Recombination: The Essence of HeredityQ38618828
Pervasive and essential roles of the Top3-Rmi1 decatenase orchestrate recombination and facilitate chromosome segregation in meiosisQ38988847
Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion.Q40806587
Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae.Q40895728
Crossover homeostasis in yeast meiosisQ41991996
Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosisQ42007696
The DNA binding activity of MutL is required for methyl-directed mismatch repair in Escherichia coliQ46919135
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P921main subjectDNA mismatch repairQ2984243
P304page(s)e1006722
P577publication date2017-05-15
P1433published inPLOS GeneticsQ1893441
P1476titleDistinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair
P478volume13

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cites work (P2860)
Q64928626A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I.
Q92918929A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity
Q90681945Biallelic germline nonsense variant of MLH3 underlies polyposis predisposition
Q90429771Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex
Q52724127Multi-Invasion-Induced Rearrangements as a Pathway for Physiological and Pathological Recombination.
Q98567982PCNA activates the MutLγ endonuclease to promote meiotic crossing over
Q98568696Regulation of the MLH1-MLH3 endonuclease in meiosis
Q92634185Resolvases, Dissolvases, and Helicases in Homologous Recombination: Clearing the Road for Chromosome Segregation
Q42352313mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.

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