The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations

scientific article

The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1998PNAS...9512404F
P356DOI10.1073/PNAS.95.21.12404
P932PMC publication ID22844
P698PubMed publication ID9770499
P5875ResearchGate publication ID13514690

P2093author name stringR D Kolodner
H Flores-Rozas
P2860cites workMutations of two PMS homologues in hereditary nonpolyposis colon cancerQ24318484
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2Q24319816
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6Q24323176
Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiaeQ27930781
The yeast gene MSH3 defines a new class of eukaryotic MutS homologues.Q27937756
Multifunctional yeast high-copy-number shuttle vectorsQ28131605
Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeastQ28131609
A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coliQ28131613
Biochemistry and genetics of eukaryotic mismatch repairQ28282377
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor CellsQ28292781
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cellsQ28292790
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repairQ28508905
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
Correlation of two-hybrid affinity data with in vitro measurementsQ29615774
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
The distribution of the numbers of mutants in bacterial populationsQ29620123
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell linesQ29620526
Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiaeQ33842093
Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators.Q34315054
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
Saccharomyces cerevisiae pms2 mutations are alleles of MLH1, and pms2-2 corresponds to a hereditary nonpolyposis colorectal carcinoma-causing missense mutationQ36560284
Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteinsQ36568343
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutationsQ36570003
Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeastQ36574453
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genesQ40022200
Micro-homology mediated PCR targeting inSaccharomyces cerevisiaeQ40395047
Fused protein domains inhibit DNA binding by LexAQ40655370
Single-strand DNA-specific exonucleases in Escherichia coli. Roles in repair and mutation avoidance.Q41777210
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutantsQ50192890
Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.Q50893078
Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression.Q53439660
Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage.Q54447827
Differential effects of the mismatch repair genes MSH2 and MSH3 on homeologous recombination in Saccharomyces cerevisiaeQ57451646
Mismatch correction at O 6 -methylguanine residues in E. coli DNAQ59049241
Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal CancerQ61946741
A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repairQ64389285
Mutational specificity of the dnaE173 mutator associated with a defect in the catalytic subunit of DNA polymerase III of Escherichia coliQ67804434
Processing of O6-methylguanine by mismatch correction in human cell extractsQ71824297
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
SH3 domainQ24771787
Mismatch repair protein MLH3 YPL164CQ27547621
Mismatch repair ATPase MLH1 YMR167WQ27552202
P304page(s)12404-9
P577publication date1998-10-13
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations
P478volume95

Reverse relations

cites work (P2860)
Q28744679A PLAC8-containing protein from an endomycorrhizal fungus confers cadmium resistance to yeast cells by interacting with Mlh3p
Q33552273A conserved MutS homolog connector domain interface interacts with MutL homologs
Q36161227A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations
Q35127316A multi-host approach for the systematic analysis of virulence factors in Cryptococcus neoformans
Q36724317A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae
Q36540457A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair
Q34093711A role for MLH3 in hereditary nonpolyposis colorectal cancer
Q27931208A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.
Q36211150A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation
Q37713613A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability
Q24564010ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage
Q35690218Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
Q34661313Adaptive mutation in Saccharomyces cerevisiae
Q31881456Adaptive reversions of a frameshift mutation in arrested Saccharomyces cerevisiae cells by simple deletions in mononucleotide repeats
Q34616364Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes
Q46564552An infant with MLH3 variants, FOXG1-duplication and multiple, benign cranial and spinal tumors: A clinical exome sequencing study
Q36614680An intact Pms2 ATPase domain is not essential for male fertility
Q34614513Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.
Q38328409Analysis of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 and MLH1-PMS1 complexes with DNA using a reversible DNA end-blocking system.
Q36231123Antibody class switch recombination: roles for switch sequences and mismatch repair proteins
Q34443496Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae
Q34270970Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene
Q34926104Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome
Q38320783Biochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA.
Q27936808Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Q46691965Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants
Q35865056Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins.
Q34612530Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors
Q42263592Cytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae
Q34967180DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.
Q28211143DNA mismatch repair and mutation avoidance pathways
Q34568596DNA mismatch repair defects: role in colorectal carcinogenesis
Q33947053DNA mismatch repair genes and colorectal cancer
Q28291067DNA mismatch repair in eukaryotes and bacteria
Q35062449DNA repair defects in colon cancer
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q28390915Defects in base excision repair sensitize cells to manganese in S. cerevisiae
Q33888905Deficiency of a novel mismatch repair activity in a bladder tumor cell line
Q40249105Demonstration and characterization of mutations induced by Helicobacter pylori organisms in gastric epithelial cells
Q28592891Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
Q35034387Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast.
Q27934236Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast
Q36371989Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair
Q40895728Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae.
Q27938305Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae
Q34609730EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae
Q92203157Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex
Q28592033Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells
Q36643853Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast
Q36764079Endonuclease activities of MutLα and its homologs in DNA mismatch repair
Q36436073Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair
Q27939116Eukaryotic DNA mismatch repair
Q24316068Evidence for involvement of HMGB1 protein in human DNA mismatch repair
Q34441207Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair.
Q39542069Evolutionary origin, diversification and specialization of eukaryotic MutS homolog mismatch repair proteins
Q28709087Evolutionary rate covariation in meiotic proteins results from fluctuating evolutionary pressure in yeasts and mammals
Q28261787Exonuclease 1-dependent and independent mismatch repair
Q33430666Fluctuation analysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis
Q35559704Folate deficiency, mismatch repair-dependent apoptosis, and human disease
Q34615262Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans
Q36862037Functional analysis helps to clarify the clinical importance of unclassified variants in DNA mismatch repair genes
Q33739955Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions
Q27939611Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
Q27929951Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.
Q52359109GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one.
Q27932384Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast
Q33943737Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers
Q35318165Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1
Q30400328High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging
Q31119964Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain
Q89517728Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion
Q36451916Human mismatch repair protein hMutLα is required to repair short slipped-DNAs of trinucleotide repeats
Q43002767Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function
Q40920177Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.
Q33967139Inactivation of DNA mismatch repair by increased expression of yeast MLH1.
Q28182219Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
Q24629057Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex
Q33933718Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae
Q58074454Involvement of DNA mismatch repair in folate deficiency-induced apoptosis☆
Q50487055Involvement of the Arabidopsis thaliana AtPMS1 gene in somatic repeat instability.
Q39675432Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair
Q34012877Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast
Q28505426Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I
Q36246487Lynch syndrome genes
Q22010995MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability
Q73075608MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae
Q36991032Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes
Q73311211Mediating mismatch repair
Q28593875Meiotic arrest and aneuploidy in MLH3-deficient mice
Q27939603Meiotic recombination involving heterozygous large insertions in Saccharomyces cerevisiae: formation and repair of large, unpaired DNA loops
Q37685585Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii
Q33626740Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions.
Q83835402Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications
Q33885063Mismatch repair defects in cancer
Q40711388Mismatch repair deficiency in hematological malignancies with microsatellite instability
Q35034398Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches
Q34194518Mismatch repair in correction of replication errors and processing of DNA damage
Q33960642Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis
Q33984294Mismatch repair proteins and mitotic genome stability
Q37691675Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex
Q28588324Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice
Q28305501Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease
Q35165645Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae
Q27931842Modulation of the DNA-binding activity of Saccharomyces cerevisiae MSH2-MSH6 complex by the high-mobility group protein NHP6A, in vitro
Q35433209Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer
Q28776215Multiple functions of MutS- and MutL-related heterocomplexes
Q22254326Multiple mutations and frameshifts are the hallmark of defective hPMS2 in pZ189-transfected human tumor cells
Q24548535Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
Q24606421MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
Q33786781Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR.
Q28084645New insights into the mechanism of DNA mismatch repair
Q34097342Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication
Q41711225Novel dominant mutations in Saccharomyces cerevisiae MSH6.
Q33343446Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
Q36090192Oligonucleotide transformation of yeast reveals mismatch repair complexes to be differentially active on DNA replication strands
Q33961620PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.
Q28610670Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A
Q27690911Postreplicative mismatch repair
Q33800274Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry
Q28142999Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex
Q53062576Proper functioning of the GINS complex is important for the fidelity of DNA replication in yeast.
Q48256887R-loops: targets for nuclease cleavage and repeat instability.
Q39608661Rapid generation of rice mutants via the dominant negative suppression of the mismatch repair protein OsPMS1.
Q37308166Reciprocal regulation of nuclear import of the yeast MutSalpha DNA mismatch repair proteins Msh2 and Msh6.
Q33556873Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins
Q37319600Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins
Q34500851Reduced meiotic crossovers and delayed prophase I progression in AtMLH3-deficient Arabidopsis
Q34608647Regulation of mitotic homeologous recombination in yeast. Functions of mismatch repair and nucleotide excision repair genes
Q98568696Regulation of the MLH1-MLH3 endonuclease in meiosis
Q33865368Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae
Q92634185Resolvases, Dissolvases, and Helicases in Homologous Recombination: Clearing the Road for Chromosome Segregation
Q34619419Role of mismatch repair in the fidelity of RAD51- and RAD59-dependent recombination in Saccharomyces cerevisiae
Q34057743Roles for mismatch repair factors in regulating genetic recombination
Q36540776Roles for mismatch repair family proteins in promoting meiotic crossing over
Q27931230Saccharomyces cerevisiae Msh2-Msh3 acts in repair of base-base mispairs
Q39449001Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair
Q34610604Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae.
Q35027619Single molecule studies of DNA mismatch repair
Q54089766Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines.
Q34613326Spontaneous frameshift mutations in Saccharomyces cerevisiae: accumulation during DNA replication and removal by proofreading and mismatch repair activities.
Q39148893Stable expression of MutLγ in human cells reveals no specific response to mismatched DNA, but distinct recruitment to damage sites.
Q34463536Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair
Q27932618The MER3 DNA helicase catalyzes the unwinding of holliday junctions
Q28306188The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctions
Q64236101The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity
Q34895336The effects of mismatch repair and RAD1 genes on interchromosomal crossover recombination in Saccharomyces cerevisiae
Q61313168The first functional study of MLH3 mutations found in cancer patients
Q24596494The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2
Q33984289The many faces of mismatch repair in meiosis
Q33615733The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans.
Q36448284The multifaceted mismatch-repair system
Q24681035The origins and early evolution of DNA mismatch repair genes--multiple horizontal gene transfers and co-evolution
Q91595501The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair
Q42011370The role of AtMSH2 in homologous recombination in Arabidopsis thaliana
Q35559695Two common forms of the human MLH1 gene may be associated with functional differences
Q36338245Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.
Q64082866Yeast expression of mammalian Onzin and fungal FCR1 suggests ancestral functions of PLAC8 proteins in mitochondrial metabolism and DNA repair
Q27935389exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair
Q42352313mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.

Search more.