Biochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA.

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Biochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.38.26668
P698PubMed publication ID10480869
P5875ResearchGate publication ID238316250

P2093author name stringKolodner RD
Marsischky GT
P2860cites workInteractions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancerQ22003969
Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 geneQ24312177
Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repairQ24318892
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6Q24323176
The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairsQ27930815
Conserved properties between functionally distinct MutS homologs in yeastQ27931606
Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.Q27932001
Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA.Q27932061
Heteroduplex DNA correction in Saccharomyces cerevisiae is mismatch specific and requires functional PMS genesQ27934736
Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.Q27934985
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiaeQ27936455
ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexesQ27939412
MutS and MutL activate DNA helicase II in a mismatch-dependent mannerQ38337755
Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded proteinQ38346658
Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotypeQ38358374
Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genesQ40022200
Characterization of distinct human endometrial carcinoma cell lines deficient in mismatch repair that originated from a single tumorQ41005472
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Characterization of the mouse Rep-3 gene: sequence similarities to bacterial and yeast mismatch-repair proteinsQ42693688
Mismatch repair, molecular switches, and signal transductionQ47787090
Frameshift mismatch recognition by the human MutS alpha complexQ47791002
cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene.Q48060657
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correctionQ48076989
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancerQ48084125
Interaction of MutS protein with the major and minor grooves of a heteroduplex DNA.Q54565774
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patientsQ57570041
Biospecific interaction analysis using surface plasmon resonance detection applied to kinetic, binding site and concentration analysisQ58547252
Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteinsQ59040284
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNAQ28138775
Binding of mismatched microsatellite DNA sequences by the human MSH2 proteinQ28241673
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancerQ28256988
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancerQ28257360
The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switchQ28258968
Biochemistry and genetics of eukaryotic mismatch repairQ28282377
Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 geneQ28282735
Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 geneQ28286499
Escherichia coli mutS-encoded protein binds to mismatched DNA base pairsQ28287503
Molecular cloning of the N-terminus of GTBPQ28292000
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor CellsQ28292781
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cellsQ28292790
Mutations of GTBP in genetically unstable cellsQ28292802
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancerQ28294774
Mammalian MutS homologue 5 is required for chromosome pairing in meiosisQ28295022
Mutation in the mismatch repair gene Msh6 causes cancer susceptibilityQ28592583
hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNAQ28610839
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairQ28610858
Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalphaQ28610863
Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanismQ28610864
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD.Q32108861
Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA.Q33857769
MutS mediates heteroduplex loop formation by a translocation mechanismQ33887145
Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correctionQ34603979
The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA.Q34657088
Base-base mismatches. Thermodynamics of double helix formation for dCA3XA3G + dCT3YT3G (X, Y = A,C,G,T).Q35556177
Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteinsQ36568343
Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.Q36568353
Mechanisms and biological effects of mismatch repairQ37041860
Repair of defined single base-pair mismatches in Escherichia coli.Q37675282
The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertionsQ38299752
hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalphaQ38336441
P433issue38
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)26668-26682
P577publication date1999-09-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleBiochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA.
P478volume274

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cites work (P2860)
Q33552273A conserved MutS homolog connector domain interface interacts with MutL homologs
Q93270681A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance
Q35038676Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements
Q39156478Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity
Q35690218Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
Q28359649Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches
Q33342762Analysis of the DNA binding activity of BRCA1 and its modulation by the tumour suppressor p53.
Q38328409Analysis of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 and MLH1-PMS1 complexes with DNA using a reversible DNA end-blocking system.
Q36290829Applying 6-methylisoxanthopterin-enhanced fluorescence to examine protein-DNA interactions in the picomolar range
Q39656345Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA.
Q38295596Asymmetric recognition of DNA local distortion. Structure-based functional studies of eukaryotic Msh2-Msh6.
Q34443496Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae
Q38356417Binding discrimination of MutS to a set of lesions and compound lesions (base damage and mismatch) reveals its potential role as a cisplatin-damaged DNA sensing protein
Q35880032Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D)
Q34270970Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene
Q34099011Both hMutSα and hMutSß DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity
Q24798955Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2-MSH6 complex
Q45129820Cadmium inhibits the functions of eukaryotic MutS complexes.
Q46691965Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants
Q35865056Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins.
Q57784307Coordinating Multi-Protein Mismatch Repair by Managing Diffusion Mechanics on the DNA
Q28211143DNA mismatch repair and mutation avoidance pathways
Q34568596DNA mismatch repair defects: role in colorectal carcinogenesis
Q35132526DNA mismatch repair: from structure to mechanism.
Q24647002DNA mismatch repair: molecular mechanism, cancer, and ageing
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q28295863DNA replication fidelity and cancer
Q35034387Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast.
Q34396924Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta}
Q43675423Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis
Q38289639Dominant Saccharomyces cerevisiae msh6 mutations cause increased mispair binding and decreased dissociation from mispairs by Msh2-Msh6 in the presence of ATP.
Q34609730EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae
Q36436073Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair
Q38355096Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in Yeast
Q36421123Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents
Q36553485Exonuclease 1 preferentially repairs mismatches generated by DNA polymerase α
Q28261787Exonuclease 1-dependent and independent mismatch repair
Q39742300Flanking sequence specificity determines coding microsatellite heteroduplex and mutation rates with defective DNA mismatch repair (MMR)
Q24619622Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation
Q27929951Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.
Q35557763Genome-wide survey of post-meiotic segregation during yeast recombination
Q59003454Guarding against mutation
Q34439328Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.
Q24812717Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability.
Q24629057Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex
Q33933718Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae
Q39675432Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair
Q24813835Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events
Q83835402Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications
Q93079487Mismatch Recognition by Saccharomyces cerevisiae Msh2-Msh6: Role of Structure and Dynamics
Q33305049Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA)
Q38254881Mismatch binding, ADP-ATP exchange and intramolecular signaling during mismatch repair
Q50335571Mismatch recognition and DNA-dependent stimulation of the ATPase activity of hMutSalpha is abolished by a single mutation in the hMSH6 subunit
Q39656168Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair
Q36283640Mismatch repair
Q34446700Mismatch repair balances leading and lagging strand DNA replication fidelity.
Q43990123Mismatch repair in human nuclear extracts. Time courses and ATP requirements for kinetically distinguishable steps leading to tightly controlled 5' to 3' and aphidicolin-sensitive 3' to 5' mispair-provoked excision
Q27931842Modulation of the DNA-binding activity of Saccharomyces cerevisiae MSH2-MSH6 complex by the high-mobility group protein NHP6A, in vitro
Q34293069Molecular mechanisms of DNA mismatch repair
Q38271431Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I.
Q64094107New Possibilities on the Horizon: Genome Editing Makes the Whole Genome Accessible for Changes
Q41711225Novel dominant mutations in Saccharomyces cerevisiae MSH6.
Q53924883Overproduction and analysis of eukaryotic multiprotein complexes in Escherichia coli using a dual-vector strategy.
Q37194752Oxidative damage and mutagenesis in Saccharomyces cerevisiae: genetic studies of pathways affecting replication fidelity of 8-oxoguanine
Q34068165PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
Q33800274Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry
Q42386247Production of truncated MBD4 protein by frameshift mutation in DNA mismatch repair-deficient cells enhances 5-fluorouracil sensitivity that is independent of hMLH1 status
Q28142999Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex
Q42911480Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway.
Q35734815Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae
Q37319600Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins
Q28258327Replicative DNA polymerase δ but not ε proofreads errors in Cis and in Trans
Q27931230Saccharomyces cerevisiae Msh2-Msh3 acts in repair of base-base mispairs
Q33640393Saccharomyces cerevisiae Msh2-Msh6 DNA binding kinetics reveal a mechanism of targeting sites for DNA mismatch repair
Q34610604Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae.
Q37132714Sequence context effect for hMSH2-hMSH6 mismatch-dependent activation
Q73291118Survey of the 1999 surface plasmon resonance biosensor literature
Q37653026The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair
Q38295775The Phe-X-Glu DNA binding motif of MutS. The role of hydrogen bonding in mismatch recognition
Q28306188The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctions
Q34315757The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent
Q44219222Transfer of the MSH2.MSH6 complex from proliferating cell nuclear antigen to mispaired bases in DNA.
Q37694831Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome
Q28253635Unfaithful DNA polymerase caught in the act
Q33847472Vaccinia virus telomeres: interaction with the viral I1, I6, and K4 proteins
Q33854065Variation in efficiency of DNA mismatch repair at different sites in the yeast genome
Q36338245Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.
Q52644492YB-1 disrupts mismatch repair complex formation, interferes with MutSα recruitment on mismatch and inhibits mismatch repair through interacting with PCNA.

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