Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae

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Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2001PNAS...98.9760T
P356DOI10.1073/PNAS.161175998
P932PMC publication ID55526
P698PubMed publication ID11481425
P5875ResearchGate publication ID11862441

P2093author name stringP T Tran
J A Simon
R M Liskay
P2860cites workHuman exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidanceQ22009967
The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesQ22010967
Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysisQ22254324
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domainsQ24599484
Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repairQ27617873
Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repairQ27629464
A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperoneQ27739168
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperoneQ27740876
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesisQ27766073
Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.Q27929951
Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.Q27932001
Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repairQ27932017
Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complexQ27932428
Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeastQ27934236
A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognitionQ27934451
MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathwayQ27934604
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repairQ27935389
MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.Q27936681
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperonesQ27938505
Eukaryotic DNA mismatch repairQ27939116
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correctionQ27939611
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesisQ27939891
Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complexQ28142999
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing overQ28282791
Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombinationQ28289308
Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reactionQ28610824
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairQ28610858
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrierQ29618081
GHKL, an emergent ATPase/kinase superfamilyQ33818817
Mammalian DNA mismatch repairQ33847720
Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiaeQ33865368
Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.Q33923929
The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiaeQ33957467
Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiaeQ33964716
DNA mismatch repair and genetic instabilityQ34090778
The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast.Q34606599
Regulation of mitotic homeologous recombination in yeast. Functions of mismatch repair and nucleotide excision repair genesQ34608647
EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiaeQ34609730
Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiaeQ34611088
Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90Q35816373
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitroQ36568265
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutationsQ36570003
Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeastQ36574453
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosisQ38293261
The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertionsQ38299752
Biochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA.Q38320783
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repairQ39449001
Saccharomyces cerevisiae exonuclease-1 plays a role in UV resistance that is distinct from nucleotide excision repairQ39724404
The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid.Q41064501
DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes.Q41284239
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutantsQ46691965
MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2.Q48065235
A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe.Q53926783
A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.Q53963518
A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repairQ64389285
Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stabilityQ71081409
DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiaeQ73406613
The MutL ATPase is required for mismatch repairQ73586223
UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiaeQ73741858
Eukaryotic mismatch repair: an updateQ77753605
The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexesQ77863139
Analysis of yeast pms1, msh2, and mlh1 mutators points to differences in mismatch correction efficiencies between prokaryotic and eukaryotic cellsQ77964964
EXO1 of Saccharomyces cerevisiae functions in mutagenesis during double-strand break repairQ78026677
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)9760-9765
P577publication date2001-07-31
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleInteractions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae
P478volume98

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cites work (P2860)
Q36161227A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations
Q36749550A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.
Q36540457A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair
Q36457060ATR-dependent pathways control hEXO1 stability in response to stalled forks.
Q35690218Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
Q28513971Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
Q34614513Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.
Q27934521Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae
Q36231123Antibody class switch recombination: roles for switch sequences and mismatch repair proteins
Q37699397Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma
Q33471395Avoiding dangerous missense: thermophiles display especially low mutation rates
Q34926104Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome
Q33791321Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1.
Q37072156Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair
Q27934255Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae
Q34816808Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
Q38351980Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability
Q39652175Conservation of functional asymmetry in the mammalian MutLα ATPase
Q40744193Contribution of human mlh1 and pms2 ATPase activities to DNA mismatch repair
Q77382253Current awareness on yeast
Q42280794DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase
Q28211143DNA mismatch repair and mutation avoidance pathways
Q34568596DNA mismatch repair defects: role in colorectal carcinogenesis
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q34196484Detection of heterozygous mutations in the genome of mismatch repair defective diploid yeast using a Bayesian approach
Q38289639Dominant Saccharomyces cerevisiae msh6 mutations cause increased mispair binding and decreased dissociation from mispairs by Msh2-Msh6 in the presence of ATP.
Q42426732EXO1 plays a role in generating type I and type II survivors in budding yeast
Q24316068Evidence for involvement of HMGB1 protein in human DNA mismatch repair
Q35564759Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zeta
Q28261787Exonuclease 1-dependent and independent mismatch repair
Q36862037Functional analysis helps to clarify the clinical importance of unclassified variants in DNA mismatch repair genes
Q27659620Functional residues on the surface of the N-terminal domain of yeast Pms1
Q27932384Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast
Q28185113Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability
Q31119964Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain
Q24292224Human exonuclease I is required for 5' and 3' mismatch repair
Q33791326Hydrolytic function of Exo1 in mammalian mismatch repair.
Q38358603Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity
Q28182219Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
Q24815214Inverted repeat-stimulated sister-chromatid exchange events are RAD1-independent but reduced in a msh2 mutant
Q47135454Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae.
Q55274152Isolation and Characterization of N-acyl Homoserine Lactone-Producing Bacteria From Cattle Rumen and Swine Intestines.
Q34617068MLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiae
Q24300483Mechanism of 5'-directed excision in human mismatch repair
Q38288690Ntg2p, a Saccharomyces cerevisiae DNA N-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidative DNA damage, interacts with the DNA mismatch repair protein Mlh1p. Identification of a Mlh1p binding motif.
Q34030005PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro
Q33961620PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.
Q28610670Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A
Q33628462Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae
Q36694981Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response
Q42911480Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway.
Q60920607Replication stress-induced Exo1 phosphorylation is mediated by Rad53/Pph3 and Exo1 nuclear localization is controlled by 14-3-3 proteins
Q36540776Roles for mismatch repair family proteins in promoting meiotic crossing over
Q35027619Single molecule studies of DNA mismatch repair
Q27684073Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site
Q27933098Supercomplex formation between Mlh1-Mlh3 and Sgs1-Top3 heterocomplexes in meiotic yeast cells
Q34463536Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair
Q28301386Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions
Q36370917The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response
Q33615733The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans.
Q27932484The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains
Q53195871The significance of Exonuclease 1 K589E polymorphism on hepatocellular carcinoma susceptibility in the Turkish population: a case-control study.
Q36162012The unstructured linker arms of Mlh1-Pms1 are important for interactions with DNA during mismatch repair
Q24298905Thymosin beta 4 expression and nuclear transport are regulated by hMLH1
Q54442651Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.
Q36338245Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.
Q27935389exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair

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