MLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiae

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MLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID1462462
P698PubMed publication ID12618391

P2093author name stringThomas A Kunkel
Polina V Shcherbakova
Rhona H Borts
Eva R Hoffmann
P2860cites workHNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexesQ24291378
Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphismsQ24292177
The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombinationQ24300831
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1Q24555123
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female miceQ24606421
Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repairQ27617873
Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPaseQ27635053
Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.Q27929951
Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiaeQ27930781
Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functionsQ27932283
Supercomplex formation between Mlh1-Mlh3 and Sgs1-Top3 heterocomplexes in meiotic yeast cellsQ27933098
Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteinsQ27937399
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correctionQ27939611
New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiaeQ28131599
MSH4 acts in conjunction with MLH1 during mammalian meiosisQ28142773
The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repairQ28186022
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing overQ28282791
Mammalian MutS homologue 5 is required for chromosome pairing in meiosisQ28295022
Meiotic pachytene arrest in MLH1-deficient miceQ28510650
Meiotic arrest and aneuploidy in MLH3-deficient miceQ28593875
Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD.Q32108861
Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeastQ33878802
Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleasesQ33888460
Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiaeQ33933718
Length and distribution of meiotic gene conversion tracts and crossovers in Saccharomyces cerevisiaeQ33955761
Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Q33957827
Estimating interference and linkage map distance from two-factor tetrad data.Q33964818
A test of the double-strand break repair model for meiotic recombination in Saccharomyces cerevisiaeQ33968364
Biochemical Mutants in the Smut Fungus Ustilago Maydis.Q33975198
The many faces of mismatch repair in meiosisQ33984289
DNA mismatch repair and genetic instabilityQ34090778
DNA mismatch repair and cancerQ34164892
Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repairQ34463536
Regulation of meiotic recombination and prophase I progression in mammalsQ34464620
Distribution of crossing over on mouse synaptonemal complexes using immunofluorescent localization of MLH1 protein.Q34606677
EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiaeQ34609730
Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiaeQ34611088
Cloning-free PCR-based allele replacement methodsQ35020750
Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.Q36568353
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutationsQ36570003
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
Chiasma functionQ40536148
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correctionQ48076989
Crossing over analysis at pachytene in man.Q50335535
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repairQ71919357
The MutL ATPase is required for mismatch repairQ73586223
EXO1 and MSH4 differentially affect crossing-over and segregationQ73899517
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P1104number of pages12
P304page(s)515-526
P577publication date2003-02-01
P1433published inGeneticsQ3100575
P1476titleMLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiae
P478volume163

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cites work (P2860)
Q36648733A Computational Approach to Estimating Nondisjunction Frequency in Saccharomyces cerevisiae.
Q36082370BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint molecules
Q41991996Crossover homeostasis in yeast meiosis
Q27931634Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q36371989Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair
Q36670109Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis
Q36571740Distinct functions of MLH3 at recombination hot spots in the mouse.
Q40895728Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae.
Q24530701Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes
Q36083305Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae.
Q27659620Functional residues on the surface of the N-terminal domain of yeast Pms1
Q27932384Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast
Q35038787Genetic exchange between homeologous sequences in mammalian chromosomes is averted by local homology requirements for initiation and resolution of recombination
Q27936830MLH1 and MSH2 promote the symmetry of double-strand break repair events at the HIS4 hotspot in Saccharomyces cerevisiae.
Q64065581Noncanonical Contributions of MutLγ to VDE-Initiated Crossovers During Meiosis
Q36540776Roles for mismatch repair family proteins in promoting meiotic crossing over
Q34463536Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair
Q28301386Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions
Q43189001The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome
Q33486516The pch2Delta mutation in baker's yeast alters meiotic crossover levels and confers a defect in crossover interference
Q42107861Trans events associated with crossovers are revealed in the absence of mismatch repair genes in Saccharomyces cerevisiae

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