Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.

scientific article published on May 1997

Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.17.5.2859
P8608Fatcat IDrelease_zstbkykglrc73hzpxttgrwh2xy
P932PMC publication ID232138
P698PubMed publication ID9111358
P5875ResearchGate publication ID14107518

P50authorDmitry A. GordeninQ55130852
Michael A ResnickQ62124589
P2093author name stringH T Tran
J D Keen
M Kricker
P2860cites workInactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instabilityQ24319995
DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiaeQ27929803
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activityQ27931124
Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functionsQ27932283
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesisQ27939891
Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspectsQ28118931
Patterns of Genetic and Phenotypic Suppression of lys2 Mutations in the Yeast SACCHAROMYCES CEREVISIAE.Q42284110
Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain.Q44920681
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancerQ45345220
Survey of human and rat microsatellites.Q48178876
rII cistrons of bacteriophage T4. DNA sequence around the intercistronic divide and positions of genetic landmarksQ48409047
Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumoursQ63407701
Frameshift mutagenesis by eucaryotic DNA polymerases in vitroQ69620654
Spectrum of spontaneous frameshift mutations. Sequences of bacteriophage T4 rII gene frameshiftsQ69729456
Exonucleolytic proofreading during replication of repetitive DNAQ70862403
Molecular analysis of mutations in mutator colorectal carcinoma cell linesQ70972736
Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stabilityQ71081409
Microsatellite instability and mismatch repair defects in cancerQ71133326
The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiaeQ72240900
Lessons from hereditary colorectal cancerQ28131788
Pathway correcting DNA replication errors in Saccharomyces cerevisiaeQ28263175
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancerQ28305622
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repairQ29618879
Adaptive mutation sequences reproduced by mismatch repair deficiencyQ33640315
Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiaeQ33842093
Meiotic gene conversion mutants in Saccharomyces cerevisiae. I. Isolation and characterization of pms1-1 and pms1-2.Q33951095
Spontaneous mutation in the Escherichia coli lacI geneQ33958486
The prevention of repeat-associated deletions in Saccharomyces cerevisiae by mismatch repair depends on size and origin of deletions.Q33968093
Selection of lys2 Mutants of the Yeast SACCHAROMYCES CEREVISIAE by the Utilization of alpha-AMINOADIPATE.Q34002073
Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthdayQ34229913
Z-DNA-forming sequences are spontaneous deletion hot spotsQ34307496
Differential expression of RNA transcripts encoding unique carboxy-terminal sequences of human parathyroid hormone-related peptideQ34307994
Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.Q34343418
Temperature-sensitive mutations in the yeast DNA polymerase I geneQ34618611
Mutator phenotypes in human colorectal carcinoma cell linesQ35568305
Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunitQ35598571
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.Q36412005
Replication slippage between distant short repeats in Saccharomyces cerevisiae depends on the direction of replication and the RAD50 and RAD52 genes.Q36555338
Altered replication and inverted repeats induce mismatch repair-independent recombination between highly diverged DNAs in yeast.Q36565513
Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteinsQ36568343
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
APC mutations in colorectal tumors with mismatch repair deficiencyQ37383704
Parathyroid hormone-related protein: biochemistry and molecular biologyQ37436735
Mutator phenotype may be required for multistage carcinogenesisQ37732904
Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotypeQ38358374
Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary-phase Escherichia coli K-12 cellsQ39841075
DNA polymerases required for repair of UV-induced damage in Saccharomyces cerevisiaeQ40016053
Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genesQ40022200
High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12.Q40388905
Microsatellite instability in inherited and sporadic neoplasmsQ40493550
DNA polymerase II, the epsilon polymerase of Saccharomyces cerevisiaeQ40777457
Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability.Q41206728
Cell-specific and regulator-induced promoter usage and messenger ribonucleic acid splicing for parathyroid hormone-related proteinQ41211109
Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma CellsQ41294837
DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell linesQ41338982
Spontaneous mutations at aprt locus in a mammalian cell line defective in mismatch recognitionQ41445831
Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.Q41676798
Mechanisms of spontaneous and induced frameshift mutation in bacteriophage T4.Q41879395
3'-->5' exonucleases of DNA polymerases epsilon and delta correct base analog induced DNA replication errors on opposite DNA strands in Saccharomyces cerevisiaeQ42117167
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectDNA mismatch repairQ2984243
P304page(s)2859-2865
P577publication date1997-05-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleHypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants
P478volume17

Reverse relations

cites work (P2860)
Q58696745A Case Study of Genomic Instability in an Industrial Strain of
Q64070379A Compendium of Mutational Signatures of Environmental Agents
Q35729697A Genetic Incompatibility Accelerates Adaptation in Yeast
Q63965569A Novel, Drug Resistance-Independent, Fluorescence-Based Approach To Measure Mutation Rates in Microbial Pathogens
Q36756806A genome-wide view of the spectrum of spontaneous mutations in yeast.
Q42266867A molecular characterization of spontaneous frameshift mutagenesis within the trpA gene of Escherichia coli.
Q36724317A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae
Q58695959A novel panel of short mononucleotide repeats linked to informative polymorphisms enabling effective high volume low cost discrimination between mismatch repair deficient and proficient tumours
Q33958881A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.
Q28534685A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability
Q48188761Abundance, distribution, and mutation rates of homopolymeric nucleotide runs in the genome of Caenorhabditis elegans
Q35038676Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements
Q73793665Analysis of microsatellites in 13 hemiascomycetous yeast species: mechanisms involved in genome dynamics
Q50332644Analytical parameters and validation of homopolymer detection in a pyrosequencing-based next generation sequencing system.
Q33384119Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiae.
Q44939272Arabidopsis thaliana AtPOLK encodes a DinB-like DNA polymerase that extends mispaired primer termini and is highly expressed in a variety of tissues
Q40597558Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure
Q34285681Avoidance of long mononucleotide repeats in codon pair usage
Q34443496Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae
Q38320783Biochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA.
Q33828325Break-induced replication is highly inaccurate
Q37142738Cadmium is a mutagen that acts by inhibiting mismatch repair.
Q34194253Carcinogenesis in the GI tract: from morphology to genetics and back again
Q37237633Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae.
Q34606398Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader
Q46691965Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants
Q35865056Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins.
Q38297805Chromosome targeting at short polypurine sites by cationic triplex-forming oligonucleotides.
Q34612185Cis-elements governing trinucleotide repeat instability in Saccharomyces cerevisiae.
Q27936220Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control
Q28474763Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes
Q24650948Comparative genomics and molecular dynamics of DNA repeats in eukaryotes
Q40806587Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion.
Q64387724Cooperation between non-essential DNA polymerases contributes to genome stability in Saccharomyces cerevisiae
Q41216018DNA mutation motifs in the genes associated with inherited diseases.
Q73357737DNA polymerase III proofreading mutants enhance the expansion and deletion of triplet repeat sequences in Escherichia coli
Q41670559DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability
Q36457026DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences
Q89983002DNA polymerase δ proofreads errors made by DNA polymerase ε
Q33754229DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1
Q28295863DNA replication fidelity and cancer
Q33537493DNA secondary structure: a common and causative factor for expansion in human disease
Q25255444DNA sequences shaped by selection for stability
Q34196484Detection of heterozygous mutations in the genome of mismatch repair defective diploid yeast using a Bayesian approach
Q35562130Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects
Q27934236Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast
Q36371989Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair
Q40895728Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae.
Q28277921Division of labor at the eukaryotic replication fork
Q92203157Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex
Q90480019Effects of OsMSH6 Mutations on Microsatellite Stability and Homeologous Recombination in Rice
Q36764079Endonuclease activities of MutLα and its homologs in DNA mismatch repair
Q43104148Escherichia coli DNA polymerase IV contributes to spontaneous mutagenesis at coding sequences but not microsatellite alleles
Q33711830Eukaryotic Mismatch Repair in Relation to DNA Replication
Q37420612Every microsatellite is different: Intrinsic DNA features dictate mutagenesis of common microsatellites present in the human genome
Q24796773Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations
Q36115776Evidence that the DNA mismatch repair system removes 1-nucleotide Okazaki fragment flaps
Q51326292Evolution of simple sequence repeat-mediated phase variation in bacterial genomes.
Q52681774Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair.
Q34701239Extensive microsatellite variation in rice induced by introgression from wild rice (Zizania latifolia Griseb.).
Q42644527Fidelity of replication of repetitive DNA in mutS and repair proficient Escherichia coli
Q54979482Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.
Q36568343Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins
Q33951115Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase.
Q35748265Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae.
Q33791245Frameshift mutation, microsatellites and mismatch repair
Q49911660Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae
Q34693488Functional analysis of human MutSalpha and MutSbeta complexes in yeast
Q33739955Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions
Q34376982Functional analysis of iceA1, a CATG-recognizing restriction endonuclease gene in Helicobacter pylori
Q34497819Functional heterologous protein expression by genetically engineered probiotic yeast Saccharomyces boulardii
Q24290314Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes
Q27659620Functional residues on the surface of the N-terminal domain of yeast Pms1
Q56749499GINS is a DNA polymerase epsilon accessory factor during chromosomal DNA replication in budding yeast
Q34750817Generation of a strong mutator phenotype in yeast by imbalanced base excision repair
Q35834445Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing
Q27932384Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast
Q34606865Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.
Q37271649Genome-wide In Silico Analysis, Characterization and Identification of Microsatellites in Spodoptera littoralis Multiple nucleopolyhedrovirus (SpliMNPV).
Q34618433Genomic Instability Induced by Mutations in Saccharomyces cerevisiae POL1
Q52589171Genomic Instability Promoted by Overexpression of Mismatch Repair Factors in Yeast: A Model for Understanding Cancer Progression.
Q38273272Genomic and global approaches to unravelling how hypermutable sequences influence bacterial pathogenesis.
Q34187406Genomic mutation rates: what high-throughput methods can tell us
Q52551102Germline mutations at microsatellite loci in homozygous and heterozygous mutants for mismatch repair and PCNA genes in Drosophila.
Q24792585Homopolymer tract length dependent enrichments in functional regions of 27 eukaryotes and their novel dependence on the organism DNA (G+C)% composition
Q40153707How a Genetically Stable Extremophile Evolves: Modes of Genome Diversification in the Archaeon Sulfolobus acidocaldarius
Q34603856Hypermutability in carcinogenesis
Q28215990Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability
Q27934694Identification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiae
Q34700410Ig gene hypermutation: a mechanism is due.
Q40988373In situ detection of frameshift mutations in mouse cells
Q39572388In vitro expansion of mammalian telomere repeats by DNA polymerase alpha-primase
Q36177419In-silico prediction and deep-DNA sequencing validation indicate phase variation in 115 Neisseria meningitidis genes.
Q33967139Inactivation of DNA mismatch repair by increased expression of yeast MLH1.
Q57802932Incompatibilities in Mismatch Repair Genes Contribute to a Wide Range of Mutation Rates in Human Isolates of Baker's Yeast
Q33345237Incompatibilities involving yeast mismatch repair genes: a role for genetic modifiers and implications for disease penetrance and variation in genomic mutation rates
Q28285253Induction of microsatellite instability by oxidative DNA damage
Q35728727Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta.
Q33719300Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair.
Q90429771Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex
Q60301717Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor
Q47135454Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae.
Q50487055Involvement of the Arabidopsis thaliana AtPMS1 gene in somatic repeat instability.
Q34012877Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast
Q35100950Isolation and characterization of polymorphic microsatellites in the genome of yak (Bos grunniens).
Q43077169Large-scale expansions of Friedreich's ataxia GAA repeats in yeast
Q36132253Lesion-Induced Mutation in the Hyperthermophilic Archaeon Sulfolobus acidocaldarius and Its Avoidance by the Y-Family DNA Polymerase Dbh.
Q34617068MLH1 mutations differentially affect meiotic functions in Saccharomyces cerevisiae
Q28544021MMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variants
Q27320576Mathematical and live meningococcal models for simple sequence repeat dynamics - coherent predictions and observations
Q36319705Mechanisms of glycosylase induced genomic instability
Q33970339Microsatellite Instability in Yeast: Dependence on the Length of the Microsatellite
Q40022200Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes
Q28262642Microsatellites: simple sequences with complex evolution
Q48244295Mismatch Repair Incompatibilities in Diverse Yeast Populations
Q36540568Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer
Q33984294Mismatch repair proteins and mitotic genome stability
Q27937434Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.
Q47313905Missense variants in hMLH1 identified in patients from the German HNPCC consortium and functional studies
Q28305501Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease
Q36128650Mutation hot spots in yeast caused by long-range clustering of homopolymeric sequences
Q34573244Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans
Q37128670Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast
Q39542902Mutational analyses of dinucleotide and tetranucleotide microsatellites in Escherichia coli: influence of sequence on expansion mutagenesis
Q28395673Mutational landscape of yeast mutator strains
Q33786781Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR.
Q39646894Mutations in polI but not mutSLH destabilize Haemophilus influenzae tetranucleotide repeats
Q53412320Mutator phenotype due to loss of heterozygosity in diploid yeast strains with mutations in MSH2 and MLH1.
Q33957827Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.
Q34919969Mutator phenotypes due to DNA replication infidelity.
Q35063954Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.
Q41671780Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii
Q34480201Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair
Q36540667Non-canonical actions of mismatch repair
Q34097342Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication
Q57009219Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1
Q33816436Numerous length polymorphisms at short tandem repeats in human cytomegalovirus.
Q35613347POS5 gene of Saccharomyces cerevisiae encodes a mitochondrial NADH kinase required for stability of mitochondrial DNA.
Q41859611Phase variable genes of Campylobacter jejuni exhibit high mutation rates and specific mutational patterns but mutability is not the major determinant of population structure during host colonization
Q41855884PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper
Q77206910Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process
Q41982548Proofreading and secondary structure processing determine the orientation dependence of CAG x CTG trinucleotide repeat instability in Escherichia coli
Q53062576Proper functioning of the GINS complex is important for the fidelity of DNA replication in yeast.
Q64388364R-loop formation by dCas9 is mutagenic in Saccharomyces cerevisiae
Q33340572Rapid accumulation of mutations during seed-to-seed propagation of mismatch-repair-defective Arabidopsis
Q50492858Reduction of stability of arabidopsis genomic and transgenic DNA-repeat sequences (microsatellites) by inactivation of AtMSH2 mismatch-repair function.
Q33865368Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae
Q26825747Replicative DNA polymerase mutations in cancer
Q28258327Replicative DNA polymerase δ but not ε proofreads errors in Cis and in Trans
Q35084896Role of endogenous retroviruses in autoimmune diseases
Q33792439Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase
Q46554910Saccharomyces cerevisiae DNA polymerase delta: high fidelity for base substitutions but lower fidelity for single- and multi-base deletions.
Q35653058Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition
Q36549257Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease
Q39449001Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair
Q34610604Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae.
Q42676800Simple sequence repeats in the Helicobacter pylori genome
Q24652779Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes
Q35728306Specialized mismatch repair function of Glu339 in the Phe-X-Glu motif of yeast Msh6
Q34604252Spectra of spontaneous frameshift mutations at the hisD3052 allele of Salmonella typhimurium in four DNA repair backgrounds
Q34613326Spontaneous frameshift mutations in Saccharomyces cerevisiae: accumulation during DNA replication and removal by proofreading and mismatch repair activities.
Q33338279Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choice
Q28507252Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers
Q73176036Strand asymmetry of +1 frameshift mutagenesis at a homopolymeric run by DNA polymerase III holoenzyme of Escherichia coli
Q31136996Targeting DNA Mismatches with Rhodium Metalloinsertors
Q35037449The "A" rule revisited: polymerases as determinants of mutational specificity
Q33957467The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae
Q53049781The Arabidopsis DNA mismatch repair gene PMS1 restricts somatic recombination between homeologous sequences.
Q34433261The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability
Q35445785The DNA damage checkpoint allows recombination between divergent DNA sequences in budding yeast
Q33254833The DNA polymerase activity of Pol epsilon holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extracts
Q43189001The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome
Q51312086The Major Replicative Histone Chaperone CAF-1 Suppresses the Activity of the DNA Mismatch Repair System in the Cytotoxic Response to a DNA-methylating Agent.
Q36026779The N terminus of Saccharomyces cerevisiae Msh6 is an unstructured tether to PCNA
Q34265917The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.
Q33691482The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis
Q34607157The effect of DNA replication mutations on CAG tract stability in yeast.
Q90084152The fitness cost of mismatch repair mutators in Saccharomyces cerevisiae: partitioning the mutational load
Q35064113The in vitro fidelity of yeast DNA polymerase δ and polymerase ε holoenzymes during dinucleotide microsatellite DNA synthesis
Q27934540The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae: insights into Pol zeta- and Pol eta-dependent frameshift mutagenesis
Q31833517The instability within: problems in current analyses of microsatellite instability
Q42617085The length of a tetranucleotide repeat tract in Haemophilus influenzae determines the phase variation rate of a gene with homology to type III DNA methyltransferases.
Q27932484The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains
Q36571784The rate and spectrum of microsatellite mutation in Caenorhabditis elegans and Daphnia pulex
Q41612088The roles of the eukaryotic DNA polymerases in DNA repair synthesis
Q36162012The unstructured linker arms of Mlh1-Pms1 are important for interactions with DNA during mismatch repair
Q42575223Topical reversion at the HIS1 locus of Saccharomyces cerevisiae. A tale of three mutants.
Q93216537Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
Q27938847Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates.
Q38940317Understanding how mismatch repair proteins participate in the repair/anti-recombination decision
Q44100502Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgene
Q27933894YNK1, the yeast homolog of human metastasis suppressor NM23, is required for repair of UV radiation- and etoposide-induced DNA damage
Q74825051Yeast ARMs (DNA at-risk motifs) can reveal sources of genome instability
Q64082866Yeast expression of mammalian Onzin and fungal FCR1 suggests ancestral functions of PLAC8 proteins in mitochondrial metabolism and DNA repair
Q49043239Yeast mutator phenotype enforced by Arabidopsis PMS1 expression
Q27935389exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair
Q42352313mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.
Q28478414p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system

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