Inactivation of DNA mismatch repair by increased expression of yeast MLH1.

scientific article

Inactivation of DNA mismatch repair by increased expression of yeast MLH1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.21.3.940-951.2001
P932PMC publication ID86684
P698PubMed publication ID11154280

P2093author name stringC A Afshari
P R Bushel
K J Martin
T A Kunkel
S E Bennett
M S Lewis
M C Hall
P V Shcherbakova
P2860cites workMLH3: a DNA mismatch repair gene associated with mammalian microsatellite instabilityQ22010995
Mismatch repair deficiency associated with overexpression of the MSH3 geneQ24681589
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesisQ27766073
Exploring the metabolic and genetic control of gene expression on a genomic scaleQ27860705
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activityQ27931124
Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complexQ27932428
The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblastsQ78109130
Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeastQ27934236
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexesQ27939412
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correctionQ27939611
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesisQ27939891
The interaction of the human MutL homologues in hereditary nonpolyposis colon cancerQ28137782
Pathway correcting DNA replication errors in Saccharomyces cerevisiaeQ28263175
Biochemistry and genetics of eukaryotic mismatch repairQ28282377
MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomasQ28288475
DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repairQ28610848
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinomaQ29615026
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell linesQ29620526
Steady-state regulation of the human DNA mismatch repair system.Q33896699
The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiaeQ33957467
Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Q33957827
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
A DNA polymerase epsilon mutant that specifically causes +1 frameshift mutations within homonucleotide runs in yeastQ34610131
The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA.Q34657088
Functional analysis of human MutSalpha and MutSbeta complexes in yeastQ34693488
Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.Q35063954
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifsQ36159638
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.Q36213486
Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.Q36568353
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutationsQ36570003
Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiaeQ38336291
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.Q40920177
Apoptosis induced by overexpression of hMSH2 or hMLH1.Q40943668
DNA-replication fidelity, mismatch repair and genome instability in cancer cellsQ41016785
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Transcriptional profiling on all open reading frames of Saccharomyces cerevisiae.Q42685209
Protein-protein interactions of HIV-1 reverse transcriptase: implication of central and C-terminal regions in subunit bindingQ43867754
Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences.Q52641055
Mutation screening in the hMLH1 gene in Swedish hereditary nonpolyposis colon cancer familiesQ58862127
Transcription of mutS and mutL-homologous genes in Saccharomyces cerevisiae during the cell cycleQ71616387
The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiaeQ72240900
Identification of a second MutL DNA mismatch repair complex (hPMS1 and hMLH1) in human epithelial cellsQ73626700
hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instabilityQ77804814
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectDNA mismatch repairQ2984243
P304page(s)940-951
P577publication date2001-02-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleInactivation of DNA mismatch repair by increased expression of yeast MLH1.
P478volume21

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cites work (P2860)
Q33513323Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeast
Q37072156Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair
Q24302011Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA
Q34967180DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.
Q27937399Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins
Q36772885Evolving views of DNA replication (in)fidelity
Q27659620Functional residues on the surface of the N-terminal domain of yeast Pms1
Q52589171Genomic Instability Promoted by Overexpression of Mismatch Repair Factors in Yeast: A Model for Understanding Cancer Progression.
Q40746606Implication of protein kinase C in the regulation of DNA mismatch repair protein expression and function
Q24791298Integrating phenotypic and expression profiles to map arsenic-response networks
Q50487055Involvement of the Arabidopsis thaliana AtPMS1 gene in somatic repeat instability.
Q35019055Methylation-induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1
Q36475458Mismatch repair hMSH2, hMLH1, hMSH6 and hPMS2 mRNA expression profiles in precancerous and cancerous urothelium
Q36009224Modulation of microRNA processing by mismatch repair protein MutLα.
Q28084645New insights into the mechanism of DNA mismatch repair
Q37637302Novel Implications in Molecular Diagnosis of Lynch Syndrome.
Q38288690Ntg2p, a Saccharomyces cerevisiae DNA N-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidative DNA damage, interacts with the DNA mismatch repair protein Mlh1p. Identification of a Mlh1p binding motif.
Q38969209Over-Expression of YLR162W in Saccharomyces cerevisiae Inhibits Cell Proliferation and Renders Cells Susceptible to the Hypoxic Conditions Induced by Cobalt Chloride
Q47793305Overexpression of MutL homolog 1 and MutS homolog 2 proteins have reversed prognostic implications for stage I-II colon cancer patients
Q53317052PMS1 from Arabidopsis thaliana: optimization of protein overexpression in Escherichia coli.
Q35027619Single molecule studies of DNA mismatch repair
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Q49043239Yeast mutator phenotype enforced by Arabidopsis PMS1 expression

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