Single molecule studies of DNA mismatch repair

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Single molecule studies of DNA mismatch repair is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.DNAREP.2014.03.007
P932PMC publication ID4310750
P698PubMed publication ID24746644

P2093author name stringDorothy A Erie
Keith R Weninger
P2860cites workMLH3: a DNA mismatch repair gene associated with mammalian microsatellite instabilityQ22010995
Human exonuclease I is required for 5' and 3' mismatch repairQ24292224
A defined human system that supports bidirectional mismatch-provoked excisionQ24298110
Mechanism of 5'-directed excision in human mismatch repairQ24300483
DNA polymerase delta is required for human mismatch repair in vitroQ24313002
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repairQ24318892
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6Q24323176
Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systemsQ24630140
Determination of protein-DNA binding constants and specificities from statistical analyses of single molecules: MutS-DNA interactionsQ24815928
Single-molecule analysis of DNA replication in Xenopus egg extractsQ27027222
Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repairQ27617873
Crystal structures of mismatch repair protein MutS and its complex with a substrate DNAQ27627633
The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatchQ27627644
Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPaseQ27635053
Monovalent cation dependence and preference of GHKL ATPases and kinasesQ27641375
Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substratesQ27641807
Structure of the human MutSalpha DNA lesion recognition complexQ27644980
Structure of the endonuclease domain of MutL: unlicensed to cut.Q27663136
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesisQ27766073
hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalphaQ38336441
Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in YeastQ38355096
Facilitated target location in biological systemsQ38597415
Dynamics of MutS-mismatched DNA complexes are predictive of their repair phenotypesQ38739461
Single-molecule FRET TACKLE reveals highly dynamic mismatched DNA-MutS complexesQ40124687
Strand-specific mismatch repair in mammalian cellsQ41602506
Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNAQ41884304
Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repairQ42160273
Structure of unliganded GRP94, the endoplasmic reticulum Hsp90. Basis for nucleotide-induced conformational changeQ42659468
DNA bending by Cro protein in specific and nonspecific complexes: implications for protein site recognition and specificityQ43660607
DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexesQ43664681
Mismatch repair in human nuclear extracts. Time courses and ATP requirements for kinetically distinguishable steps leading to tightly controlled 5' to 3' and aphidicolin-sensitive 3' to 5' mispair-provoked excisionQ43990123
Differential requirement for proliferating cell nuclear antigen in 5' and 3' nick-directed excision in human mismatch repairQ44761854
Stable and functional immobilization of histidine-tagged proteins via multivalent chelator headgroups on a molecular poly(ethylene glycol) brushQ46461739
Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI.Q46530498
Analysis of the quaternary structure of the MutL C-terminal domainQ46604277
Specific and stable fluorescence labeling of histidine-tagged proteins for dissecting multi-protein complex formationQ46944358
MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2.Q48065235
Endonucleolytic function of MutLalpha in human mismatch repairQ50335575
The diffusion constant of a labeled protein sliding along DNA.Q51592959
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory.Q52732418
A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.Q53963518
[Homologs of MutS and MutL during mammalian meiosis].Q54522520
Visualization of single molecules of RNA polymerase sliding along DNA.Q54647002
Bi-directional Processing of DNA Loops by Mismatch Repair-dependent and -independent Pathways in Human CellsQ58074430
DNA template requirements for human mismatch repair in vitroQ64387816
DNA mismatch repair and cancerQ73282031
Interaction of Escherichia coli MutS and MutL at a DNA mismatchQ73923892
A novel single-molecule study to determine protein--protein association constantsQ74013434
Visualizing DNA replication at the single-molecule levelQ84565022
Single-molecule DNA repair in live bacteria.Q36855094
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repairQ37181822
Involvement of the beta clamp in methyl-directed mismatch repair in vitro.Q37432125
Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repairQ37592729
ATP alters the diffusion mechanics of MutS on mismatched DNA.Q37683114
Atomic force microscopy captures MutS tetramers initiating DNA mismatch repair.Q38254948
Detection of high-affinity and sliding clamp modes for MSH2-MSH6 by single-molecule unzipping force analysisQ38317910
Bidirectional excision in methyl-directed mismatch repairQ38318540
Analysis of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 and MLH1-PMS1 complexes with DNA using a reversible DNA end-blocking system.Q38328409
Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.Q27929951
The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairsQ27930815
Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeastQ27934236
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimerQ27936605
Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterilityQ28182219
The lac repressor-operator interaction. 3. Kinetic studiesQ28247930
DNA mismatch repairQ28256190
The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switchQ28258968
Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signallingQ28264548
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor CellsQ28292781
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cellsQ28292790
DNA mismatch repair: functions and mechanismsQ28296096
Single-molecule analysis reveals the kinetics and physiological relevance of MutL-ssDNA bindingQ28476139
Meiotic arrest and aneuploidy in MLH3-deficient miceQ28593875
Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein AQ28610670
Mechanism of MutS searching for DNA mismatches and signaling repairQ28756121
Structure-based model of the stepping motor of PcrA helicaseQ28768048
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complexQ29617515
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA.Q30477242
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusionQ30483015
A peptide tag system for facile purification and single-molecule immobilizationQ30492389
Detecting the conformation of individual proteins in live cellsQ30493864
Dynamic basis for one-dimensional DNA scanning by the mismatch repair complex Msh2-Msh6.Q30496957
Single-molecule imaging reveals target-search mechanisms during DNA mismatch repairQ30528236
Facilitated target location on DNA by individual Escherichia coli RNA polymerase molecules observed with the scanning force microscope operating in liquid.Q30708246
Single-molecule imaging of RNA polymerase-DNA interactions in real timeQ31917016
Reconstitution of 5'-directed human mismatch repair in a purified systemQ33222844
Human mismatch repair: reconstitution of a nick-directed bidirectional reactionQ33224078
Real-time single-molecule observation of rolling-circle DNA replicationQ33401167
Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repairQ33465403
Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alphaQ33645614
GHKL, an emergent ATPase/kinase superfamilyQ33818817
MutS mediates heteroduplex loop formation by a translocation mechanismQ33887145
Nonspecifically bound proteins spin while diffusing along DNA.Q33929106
Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiaeQ33933718
Inactivation of DNA mismatch repair by increased expression of yeast MLH1.Q33967139
Stoichiometry and architecture of active DNA replication machinery in Escherichia coliQ34022163
Direct observation of enzymes replicating DNA using a single-molecule DNA stretching assayQ34035354
DNA mismatch repair and genetic instabilityQ34090778
Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalphaQ34123282
Direct observation of one-dimensional diffusion and transcription by Escherichia coli RNA polymeraseQ34171591
Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin latticeQ34193203
Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperoneQ34338453
Four-Color Single-Molecule Fluorescence with Noncovalent Dye Labeling to Monitor Dynamic Multimolecular ComplexesQ34373984
DNA bending and unbending by MutS govern mismatch recognition and specificityQ34385782
Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta}Q34396924
The selection for mismatch repair defects in hereditary nonpolyposis colorectal cancer: revising the mutator hypothesis.Q34405031
Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangementsQ34575808
Functional analysis of human MutSalpha and MutSbeta complexes in yeastQ34693488
MutS switches between two fundamentally distinct clamps during mismatch repairQ34698570
DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.Q34967180
Microsatellite repeat instability and neurological diseaseQ35064141
Quantitative characterization of biomolecular assemblies and interactions using atomic force microscopyQ35073581
Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loopsQ35409526
Mismatch repair and response to DNA-damaging antitumour therapiesQ35548710
DNA mismatch repair: molecular mechanisms and biological functionQ35550610
Human mismatch repair, drug-induced DNA damage, and secondary cancer.Q35630361
Mutations in DNA mismatch repair genes: implications for DNA damage signaling and drug sensitivity (review).Q35686587
Interplay between mismatch repair and chromatin assemblyQ35750965
Mismatch repair proteins, meiosis, and mice: understanding the complexities of mammalian meiosisQ35761810
The rotation-coupled sliding of EcoRVQ35956081
Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.Q36338245
Saccharomyces cerevisiae MutLalpha is a mismatch repair endonucleaseQ36549257
Exonuclease 1 preferentially repairs mismatches generated by DNA polymerase αQ36553485
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutationsQ36570003
Central dogma at the single-molecule level in living cellsQ36692659
P921main subjectDNA mismatch repairQ2984243
P304page(s)71-81
P577publication date2014-04-18
P1433published inDNA RepairQ3894086
P1476titleSingle molecule studies of DNA mismatch repair
P478volume20

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cites work (P2860)
Q36540457A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair
Q36296925Atomic force microscopy captures the initiation of methyl-directed DNA mismatch repair
Q57060631Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS
Q78177428DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens.
Q36540658DNA mismatch repair and the DNA damage response
Q35666411Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress
Q36549244Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.
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Q36560065Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2.
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Q91808014Homologous Recombination under the Single-Molecule Fluorescence Microscope
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Q38254881Mismatch binding, ADP-ATP exchange and intramolecular signaling during mismatch repair
Q38923851Mismatch repair system proteins in oral benign and malignant lesions
Q36055693MutL traps MutS at a DNA mismatch
Q30829969Single molecule techniques in DNA repair: a primer
Q39237485Single-Molecule FRET to Measure Conformational Dynamics of DNA Mismatch Repair Proteins
Q42511820Single-Nucleotide Polymorphisms of the MSH2 and MLH1 Genes, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population
Q44873571Using Atomic Force Microscopy to Characterize the Conformational Properties of Proteins and Protein-DNA Complexes That Carry Out DNA Repair.
Q47206557We FRET so You Don't Have To: New Models of the Lipoprotein Lipase Dimer

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