| scholarly article | Q13442814 |
| P2093 | author name string | Polina V Shcherbakova | |
| Elizabeth A Moore | |||
| Daniel P Kane | |||
| Stephanie R Barbari | |||
| P2860 | cites work | Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas | Q24617520 |
| Comprehensive molecular characterization of human colon and rectal cancer | Q24630415 | ||
| Toward a Shared Vision for Cancer Genomic Data | Q26966456 | ||
| Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ | Q27687755 | ||
| DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae | Q27929803 | ||
| Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity | Q27931124 | ||
| New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites | Q28131597 | ||
| Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae | Q28131610 | ||
| Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis | Q28245001 | ||
| Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication | Q28248149 | ||
| Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers | Q28256331 | ||
| A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine | Q28260241 | ||
| The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data | Q28266682 | ||
| Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers | Q28270798 | ||
| A panoply of errors: polymerase proofreading domain mutations in cancer | Q28272700 | ||
| DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer | Q28287769 | ||
| Integrated genomic characterization of endometrial carcinoma | Q28289962 | ||
| New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis | Q28307340 | ||
| In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta | Q28354217 | ||
| Signatures of mutational processes in human cancer | Q29547191 | ||
| COSMIC: exploring the world's knowledge of somatic mutations in human cancer | Q29615725 | ||
| A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability | Q33591410 | ||
| Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae | Q33628462 | ||
| A mutation in POLE predisposing to a multi-tumour phenotype | Q33836509 | ||
| Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations. | Q33957827 | ||
| Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer | Q34705149 | ||
| Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment | Q34982562 | ||
| Prognostic significance of POLE proofreading mutations in endometrial cancer. | Q34994583 | ||
| Polymerase ɛ (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing | Q35007615 | ||
| Role of DNA mismatch repair defects in the pathogenesis of human cancer | Q35085461 | ||
| Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer | Q35154300 | ||
| Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity | Q35616094 | ||
| A clinically applicable molecular-based classification for endometrial cancers | Q35863143 | ||
| Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis | Q36082471 | ||
| Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants. | Q36568353 | ||
| Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma | Q36637663 | ||
| Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma | Q36850230 | ||
| Recurrent R-spondin fusions in colon cancer | Q36949683 | ||
| Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer | Q36951751 | ||
| Molecular Analysis of Mixed Endometrial Carcinomas Shows Clonality in Most Cases. | Q37268075 | ||
| DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice | Q37386020 | ||
| DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures | Q37416977 | ||
| A novel germline POLE mutation causes an early onset cancer prone syndrome mimicking constitutional mismatch repair deficiency. | Q37592779 | ||
| Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. | Q38798543 | ||
| Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study | Q38839775 | ||
| DNA Replication-A Matter of Fidelity | Q38853128 | ||
| Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy | Q39421725 | ||
| Mutation spectrum of POLE and POLD1 mutations in South East Asian women presenting with grade 3 endometrioid endometrial carcinomas. | Q40126456 | ||
| Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma. | Q41593170 | ||
| A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading | Q41990410 | ||
| Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy | Q42821853 | ||
| Response to PD-1 Blockade in Microsatellite Stable Metastatic Colorectal Cancer Harboring a POLE Mutation. | Q45979172 | ||
| Comprehensive Analysis of Hypermutation in Human Cancer | Q46592106 | ||
| Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours. | Q47647485 | ||
| Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas | Q48404100 | ||
| Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis. | Q51006500 | ||
| Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis. | Q53210791 | ||
| Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing. | Q54275718 | ||
| POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium. | Q54351302 | ||
| Defective DNA polymerase-delta proofreading causes cancer susceptibility in mice | Q73954766 | ||
| P433 | issue | 3 | |
| P921 | main subject | Saccharomyces cerevisiae | Q719725 |
| P304 | page(s) | 1019-1029 | |
| P577 | publication date | 2018-03-02 | |
| P1433 | published in | G3 | Q5512701 |
| P1476 | title | Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae | |
| P478 | volume | 8 |
| Q61124737 | A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme |
| Q89983002 | DNA polymerase δ proofreads errors made by DNA polymerase ε |
| Q64109038 | Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient |
| Q95326700 | Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction |
| Q94467585 | Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors |
| Q92009964 | POLE proofreading defects: Contributions to mutagenesis and cancer |
| Q64997686 | Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load. |
| Q98463593 | Role of POLE and POLD1 in familial cancer |
| Q97529348 | Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes |
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