Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy

scientific article published on 28 September 2016

Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/2159-8290.CD-16-0575
P932PMC publication ID5140283
P698PubMed publication ID27683556

P50authorElaine MardisQ5353251
Sonika DahiyaQ55545315
Edward ChangQ87411690
P2093author name stringRobert E Schmidt
Gavin P Dunn
Christopher A Miller
Arie Perry
Tanner M Johanns
Christina Tsien
Ravindra Uppaluri
Cole Ferguson
George Ansstas
Ian G Dorward
P2860cites workGermline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomasQ24617520
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolutionQ27321859
Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency.Q27853362
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Comprehensive molecular characterization of gastric adenocarcinomaQ28244985
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial CancerQ28260529
PD-1 Blockade in Tumors with Mismatch-Repair DeficiencyQ28262647
ClinVar: public archive of interpretations of clinically relevant variantsQ28603051
Signatures of mutational processes in human cancerQ29547191
SIFT: Predicting amino acid changes that affect protein functionQ29547211
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencingQ29614647
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancerQ29615679
COSMIC: exploring the world's knowledge of somatic mutations in human cancerQ29615725
Genetic basis for clinical response to CTLA-4 blockade in melanomaQ29620594
Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatmentQ33865925
Mutational analysis reveals the origin and therapy-driven evolution of recurrent gliomaQ34391844
Neoantigens in cancer immunotherapy.Q34470074
Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolutionQ35157212
Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatmentQ35787908
Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosisQ36082471
pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigensQ36521595
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockadeQ37173548
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoeditingQ37418530
Molecular and cellular heterogeneity: the hallmark of glioblastomaQ38272723
Principles of immunology and its nuances in the central nervous systemQ38620084
Getting personal with neoantigen-based therapeutic cancer vaccinesQ39945813
Predicting functional effect of human missense mutations using PolyPhen-2.Q42406410
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencingQ47163678
Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomasQ48404100
Spatiotemporal Evolution of the Primary Glioblastoma Genome.Q52149231
P433issue11
P921main subjectpatientQ181600
glioblastomaQ282142
immunotherapyQ1427096
P304page(s)1230-1236
P577publication date2016-09-28
P1433published inCancer DiscoveryQ15724440
P1476titleImmunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy
P478volume6

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cites work (P2860)
Q64969067A case study of a long-term glioblastoma survivor with unmethylated MGMT and hypermutated genotype.
Q90228006Accounting for proximal variants improves neoantigen prediction
Q90648467Actively personalized vaccination trial for newly diagnosed glioblastoma
Q47569046Advances in immunotherapeutic research for glioma therapy.
Q39243060Applied Cancer Immunogenomics: Leveraging Neoantigen Discovery in Glioblastoma
Q64090740Association of BRCA1- and BRCA2-deficiency with mutation burden, expression of PD-L1/PD-1, immune infiltrates, and T cell-inflamed signature in breast cancer
Q64087356BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer
Q47304287Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastomas
Q39181810Biomarkers and Immunotherapeutic Targets in Glioblastoma
Q38847147Cancer Immunogenomics: Computational Neoantigen Identification and Vaccine Design.
Q64254749Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma
Q38635512Clinical Trials Investigating Immune Checkpoint Blockade in Glioblastoma
Q90730544Clinical activity and safety of atezolizumab in patients with recurrent glioblastoma
Q64267591Clinical chimeric antigen receptor-T cell therapy: a new and promising treatment modality for glioblastoma
Q42696942ClonEvol: clonal ordering and visualization in cancer sequencing
Q47621538Combining DNA damaging therapeutics with immunotherapy: more haste, less speed.
Q46592106Comprehensive Analysis of Hypermutation in Human Cancer
Q46037449Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.
Q55457323Current state of immunotherapy for glioblastoma.
Q39384263DNA Damage and Repair Biomarkers of Immunotherapy Response
Q57486475Dendritic Cell Cancer Therapy: Vaccinating the Right Patient at the Right Time
Q64268794Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma
Q55025484Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair.
Q55457095Durable Complete Responses in Some Recurrent High Grade Glioma Patients Treated with Toca 511 & Toca FC.
Q92839701Effects of ASPP2 on proliferation and apoptosis of malignant spinal tumor cells
Q52674249Exome analysis of carotid body tumor.
Q91734249Extensive Leptomeningeal Intracranial and Spinal Metastases in a Patient with a Supratentorial Glioblastoma Multiforme, IDH-Wildtype
Q49911660Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae
Q92179996Genomic correlates of response to immune checkpoint blockade
Q38676440Genomic landscape of high-grade meningiomas.
Q92830555Genomics-Enabled Precision Medicine for Cancer
Q58110826Germline mutation p.N363K in POLE is associated with an increased risk of colorectal cancer and giant cell glioblastoma
Q64110950Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma
Q89767107Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
Q94365704Highlights from the Literature
Q90399651Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations
Q38743793Immune Checkpoint Inhibitors in Gliomas.
Q47915209Immunotherapies for malignant glioma.
Q90623091Immunotherapy Against Gliomas: is the Breakthrough Near?
Q47555498Immunotherapy for brain tumors: understanding early successes and limitations
Q90640719Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens
Q90661815Lynch syndrome-associated ultra-hypermutated pediatric glioblastoma mimicking a constitutional mismatch repair deficiency syndrome
Q64252479Mechanisms of Primary and Secondary Resistance to Immune Checkpoint Inhibitors in Cancer
Q56886821Mechanisms of Resistance to Immune Checkpoint Blockade
Q92267431Mechanisms of immunotherapy resistance: lessons from glioblastoma
Q92799371Molecular Neuropathology in Practice: Clinical Profiling and Integrative Analysis of Molecular Alterations in Glioblastoma
Q58107960Molecular predictors of response to PD-1/PD-L1 inhibition in urothelial cancer
Q97543564Molecular profiling-based decision for targeted therapies in IDH wild-type glioblastoma
Q90472252Multiparametric MRI for early identification of therapeutic response in recurrent glioblastoma treated with immune checkpoint inhibitors
Q57060417N2M2 (NOA20) phase I/II trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma
Q62745893Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
Q47221163Neoantigen Targeting-Dawn of a New Era in Cancer Immunotherapy?
Q58543063Novel POLE pathogenic germline variant in a family with multiple primary tumors results in distinct mutational signatures
Q63383798PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer
Q47140563PD-1 inhibitors in endometrial cancer
Q55277238Pediatric High Grade Gliomas in the Context of Cancer Predisposition Syndromes.
Q90175028Pleomorphic xanthoastrocytoma: a brief review
Q47701712Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer
Q55456776Precision Neuro-oncology: the Role of Genomic Testing in the Management of Adult and Pediatric Gliomas.
Q57176314Programmed Death Ligand 1 Is a Negative Prognostic Marker in Recurrent Isocitrate Dehydrogenase-Wildtype Glioblastoma
Q45999303Prospective feasibility trial for genomics-informed treatment in recurrent and progressive glioblastoma.
Q96432088Prostate carcinogenesis: inflammatory storms
Q57798069RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma
Q60914597Recent Advances in Oncolytic Virotherapy and Immunotherapy for Glioblastoma: A Glimmer of Hope in the Search for an Effective Therapy?
Q39421725Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy
Q92881504Resistance Mechanisms and Barriers to Successful Immunotherapy for Treating Glioblastoma
Q38373829SOX2 immunity and tissue resident memory in children and young adults with glioma
Q42745976Successful Treatment of a Patient with Glioblastoma and a Germline POLE Mutation: Where Next?
Q97543552TP53, ATRX alterations, and low tumor mutation load feature IDH-wildtype giant cell glioblastoma despite exceptional ultra-mutated tumors
Q90707206Targeting DNA repair in cancer: current state and novel approaches
Q50130464Targeting Neoantigens in Glioblastoma: An Overview of Cancer Immunogenomics and Translational Implications.
Q61800092Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities
Q49922510Temozolomide-associated Hypermutation in Gliomas
Q58119182The DNA damage response in immunotherapy and radiation
Q61449923The Prognostic and Therapeutic Value of PD-L1 in Glioma
Q89684724The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas
Q91728273Therapeutic implications of germline genetic findings in cancer
Q90057920Treatment of an Aggressive Orthotopic Murine Glioblastoma Model with Combination Checkpoint Blockade and a Multivalent Neoantigen Vaccine
Q46410671Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Q90273707Tumor mutational burden is associated with poor outcomes in diffuse glioma
Q92452822Tumoral and immune heterogeneity in an anti-PD-1-responsive glioblastoma: a case study
Q50112440Tumour heterogeneity and resistance to cancer therapies
Q49865882Unwrapping the genomic characteristics of urothelial bladder cancer and successes with immune checkpoint blockade therapy
Q52623832Vaccine Strategies in Gliomas.
Q63246502Virus-Based Immunotherapy of Glioblastoma