Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities

scientific article published on 04 February 2019

Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FONC.2019.00041
P932PMC publication ID6369148
P698PubMed publication ID30778375

P50authorSiham SabriQ57612301
Janusz RakQ67256958
Ahmad ChaddadQ39934599
P2093author name stringBassam S Abdulkarim
Brian Meehan
Bertrand Jean-Claude
Paul Daniel
P2860cites workA distinct "side population" of cells with high drug efflux capacity in human tumor cellsQ24564100
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structuresQ24606873
Identification of a CpG island methylator phenotype that defines a distinct subgroup of gliomaQ24612429
IDH1 and IDH2 mutations in gliomasQ24648948
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Structural and functional features of central nervous system lymphatic vesselsQ27316769
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agentsQ27777800
Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency.Q27853362
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.Q55463299
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain TumorQ57815290
Abscopal effect of radiotherapy combined with immune checkpoint inhibitorsQ58773898
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DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significanceQ73724513
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Combining radiation therapy and cancer immune therapies: From preclinical findings to clinical applicationsQ91345120
Identification of a cancer stem cell in human brain tumorsQ28131688
The somatic genomic landscape of glioblastomaQ28300185
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastomaQ29615604
A restricted cell population propagates glioblastoma growth after chemotherapyQ29615605
Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis.Q30249563
CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010.Q30427255
Improved survival time trends for glioblastoma using the SEER 17 population-based registriesQ33828439
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Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repairQ34723491
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Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastomaQ35232507
Genetic pathways to primary and secondary glioblastomaQ35757144
Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatmentQ35787908
Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to TemozolomideQ35920638
Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro modelsQ36059965
The Changes in MGMT Promoter Methylation Status in Initial and Recurrent GlioblastomasQ36310665
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.Q36673354
Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM ModelQ38739262
The Damaging Effect of Passenger Mutations on Cancer ProgressionQ38768283
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summaryQ38829244
Clonal evolution of glioblastoma under therapy.Q39704836
An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cellsQ40250980
Structure, Function, and Inhibition of O6-Alkylguanine-DNA AlkyltransferaseQ40473972
M2 macrophages are more resistant than M1 macrophages following radiation therapy in the context of glioblastomaQ42700764
Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade ImmunotherapyQ42821853
MGMT promoter hypermethylation in a series of 104 glioblastomasQ43298120
Chromatin marks shape mutation landscape at early stage of cancer progressionQ47094097
Tumor Mutational Burden and Response Rate to PD-1 Inhibition.Q47270933
Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy.Q47903730
Ionizing radiation induces O6-alkylguanine-DNA-alkyltransferase mRNA and activity in mouse tissuesQ48310488
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanineQ48479768
Radiotherapy Upregulates Programmed Death Ligand-1 through the Pathways Downstream of Epidermal Growth Factor Receptor in GliomaQ49359610
Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitizationQ50089383
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.Q50116977
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectRecurrenceQ1903551
temozolomideQ425088
gliomaQ1365309
P304page(s)41
P577publication date2019-02-04
P1433published inFrontiers in OncologyQ26839986
P1476titleTemozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities
P478volume9

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cites work (P2860)
Q100945825BET degrader inhibits tumor progression and stem-like cell growth via Wnt/β-catenin signaling repression in glioma cells
Q91820401CDK4/6 inhibition suppresses tumour growth and enhances the effect of temozolomide in glioma cells
Q90380770Glypican-1 in human glioblastoma: implications in tumorigenesis and chemotherapy
Q97555747Human genes differ by their UV sensitivity estimated through analysis of UV-induced silent mutations in melanoma
Q92675121Inhibition of Metabolic Shift can Decrease Therapy Resistance in Human High-Grade Glioma Cells
Q93167485Long Non-coding RNA EPIC1 Promotes Cell Proliferation and Motility and Drug Resistance in Glioma
Q99630184Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway
Q92004993Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT
Q96155628Next Generation Sequencing and Machine Learning Technologies Are Painting the Epigenetic Portrait of Glioblastoma
Q91790776Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide
Q99413885Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Smart Drug Delivery Systems in the Treatment of Glioblastoma Multiforme
Q89684724The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas
Q91736360circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling
Q90160575miR-152-5p suppresses glioma progression and tumorigenesis and potentiates temozolomide sensitivity by targeting FBXL7

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