Resolvases, Dissolvases, and Helicases in Homologous Recombination: Clearing the Road for Chromosome Segregation

scientific article published on 08 January 2020

Resolvases, Dissolvases, and Helicases in Homologous Recombination: Clearing the Road for Chromosome Segregation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/GENES11010071
P932PMC publication ID7017083
P698PubMed publication ID31936378

P50authorAndrés Clemente-BlancoQ80066543
P2093author name stringPedro A San-Segundo
P2860cites workCdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repairQ21144986
Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertilityQ21245297
The Bloom's syndrome gene product is homologous to RecQ helicasesQ24313440
Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiaeQ24548169
Mutations of the SLX4 gene in Fanconi anemiaQ24628650
Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptorQ27324663
Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2Q27677554
Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1Q27681649
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesQ27860662
A comprehensive two-hybrid analysis to explore the yeast protein interactomeQ27861093
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processingQ27929897
Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1Q27930407
Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forksQ27930441
Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiaeQ27931342
RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis.Q27932144
Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.Q27932379
Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeastQ27932384
Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleasesQ27932385
Budding Yeast SLX4 Contributes to the Appropriate Distribution of Crossovers and Meiotic Double-Strand Break Formation on Bivalents During MeiosisQ27932605
Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repairQ27933139
An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forksQ27933571
Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.Q27934090
Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeastQ27934236
Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicaseQ27934381
Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifsQ27934845
Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosisQ27934904
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.Q27934939
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiaeQ27935770
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonucleaseQ27935913
Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?Q27936167
MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.Q27936681
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosisQ27936840
Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicaseQ27936891
Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae.Q41768296
Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage.Q41785600
Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosisQ42007696
The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosisQ42015953
Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4.Q42030288
A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication.Q42108506
A global view of meiotic double-strand break end resectionQ42176298
Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6.Q42203705
The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkagesQ42395973
Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination RegulationQ42596381
Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.Q42793326
Inhibition of the Smc5/6 complex during meiosis perturbs joint molecule formation and resolution without significantly changing crossover or non-crossover levels.Q42917873
Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregationQ44566568
Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2pQ46576875
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaksQ46952804
Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2.Q47104636
The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damageQ47243177
PARPi focus the spotlight on replication fork protection in cancer.Q47583474
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correctionQ48076989
Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes.Q48256770
Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomesQ27937337
Identification of Holliday junction resolvases from humans and yeastQ27937498
Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinaseQ27938070
Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenanceQ27938444
Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.Q27938895
RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombinationQ27939265
Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.Q27939352
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correctionQ27939611
MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiaeQ27939646
Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediatesQ27940191
Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.Q27940287
Meiotic crossover control by concerted action of Rad51-Dmc1 in homolog template bias and robust homeostatic regulationQ27940335
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyraseQ28170377
SUMO-modified PCNA recruits Srs2 to prevent recombination during S phaseQ28254244
BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolismQ28264465
Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvaseQ28264475
Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctionsQ28301386
Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonucleaseQ28305501
The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctionsQ28306188
Gradual implementation of the meiotic recombination program via checkpoint pathways controlled by global DSB levelsQ28649852
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break endsQ29615269
DNA helicase Srs2 disrupts the Rad51 presynaptic filamentQ29618305
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeastQ29618612
The PHD finger: implications for chromatin-mediated transcriptional regulationQ29620426
Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1.Q30827295
OsSEND-1: a new RAD2 nuclease family member in higher plantsQ33338122
Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombinationQ33347993
Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repairQ33408756
The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans.Q33615733
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.Q33681974
Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loopsQ33719607
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stressQ33751481
Meiotic recombination intermediates are resolved with minimal crossover formation during return-to-growth, an analogue of the mitotic cell cycleQ33921194
The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates.Q33938817
The Smc5-Smc6 complex is required to remove chromosome junctions in meiosis.Q33952127
Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpointQ36438748
DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9Q36508259
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL geneQ36643609
DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage.Q36663129
Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1.Q36715620
A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiaeQ36724317
Mutants defective in Rad1-Rad10-Slx4 exhibit a unique pattern of viability during mating-type switching in Saccharomyces cerevisiaeQ36836982
MTE1 Functions with MPH1 in Double-Strand Break RepairQ36875579
The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repairQ37127298
Structural and functional relationships of the XPF/MUS81 family of proteinsQ37179480
Putative antirecombinase Srs2 DNA helicase promotes noncrossover homologous recombination avoiding loss of heterozygosityQ37218424
Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediatesQ37283116
Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruptionQ37421132
Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domainsQ37577441
Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosisQ37673546
Srs2 prevents Rad51 filament formation by repetitive motion on DNA.Q37691468
RecQ Helicases: Conserved Guardians of Genomic Integrity.Q38060579
Self-organization of meiotic recombination initiation: general principles and molecular pathwaysQ38271059
Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonucleaseQ38293464
The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damageQ38319089
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
Meiotic Recombination: The Essence of HeredityQ38618828
Subnuclear Relocalization of Structure-Specific Endonucleases in Response to DNA DamageQ38622049
The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability.Q38777052
Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instabilityQ38786931
A Life Investigating Pathways That Repair Broken ChromosomesQ38978945
Pervasive and essential roles of the Top3-Rmi1 decatenase orchestrate recombination and facilitate chromosome segregation in meiosisQ38988847
Multifunctional roles of Saccharomyces cerevisiae Srs2 protein in replication, recombination and repairQ39052177
Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damageQ39498251
Structural and Mechanistic Analysis of the Slx1-Slx4 EndonucleaseQ39893896
Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossoverQ39947084
Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing.Q40101630
Cdc14 targets the Holliday junction resolvase Yen1 to the nucleus in early anaphaseQ40464973
DmGEN, a novel RAD2 family endo-exonuclease from Drosophila melanogasterQ40637329
Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeastQ40816101
Smc5/6 is required for repair at collapsed replication forksQ41076824
The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defectsQ41117313
Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates.Q41335010
The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH geneQ33957478
Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutantsQ33959832
Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotesQ34025948
Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4Q34298450
Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replicationQ34430247
Top3-Rmi1 DNA single-strand decatenase is integral to the formation and resolution of meiotic recombination intermediatesQ34463801
DNA RECOMBINATION. Base triplet stepping by the Rad51/RecA family of recombinasesQ34491322
Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeastQ34492648
Competing crossover pathways act during meiosis in Saccharomyces cerevisiaeQ34569381
The Mus81/Mms4 Endonuclease Acts Independently of Double-Holliday Junction Resolution to Promote a Distinct Subset of Crossovers During Meiosis in Budding YeastQ34617616
Heteroduplex DNA position defines the roles of the Sgs1, Srs2, and Mph1 helicases in promoting distinct recombination outcomesQ34629211
Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repairQ34644150
Slx1-Slx4 are subunits of a structure-specific endonuclease that maintains ribosomal DNA in fission yeast.Q34785526
Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activitiesQ35059088
Smc5/6-Mms21 prevents and eliminates inappropriate recombination intermediates in meiosis.Q35079911
Top3-Rmi1 dissolve Rad51-mediated D loops by a topoisomerase-based mechanismQ35113821
The Mechanism of Mus81-Mms4 Cleavage Site Selection Distinguishes It from the Homologous Endonuclease Rad1-Rad10Q35148358
Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formationQ35541880
The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctionsQ35643073
Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchangeQ35943337
RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the geneQ35945829
DNA helicases involved in DNA repair and their roles in cancerQ35961508
BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint moleculesQ36082370
Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repairQ36210916
The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeatsQ36236720
Making crossovers during meiosisQ36295514
Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repairQ36371989
Mechanistic View and Genetic Control of DNA Recombination during Meiosis.Q52329930
Mus81-Mms4 and Yen1 resolve a novel anaphase bridge formed by noncanonical Holliday junctions.Q52997071
Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.Q55055759
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtypeQ55671559
Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinaseQ57292165
Context-dependent remodeling of Rad51-DNA complexes by Srs2 is mediated by a specific protein-protein interactionQ57755739
Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formationQ59326816
Homologous Recombination: To Fork and BeyondQ60919487
Regulation of Structure-Specific Endonucleases in Replication StressQ60955060
Regulated Crossing-Over Requires Inactivation of Yen1/GEN1 Resolvase during Meiotic Prophase IQ63965511
Structure-Specific Endonucleases and the Resolution of Chromosome UnderreplicationQ64075900
The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filamentsQ64114343
Dynamic Processing of Displacement Loops during Recombinational DNA RepairQ64387930
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repairQ71919357
Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicasesQ73844491
DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress responseQ84617121
TOPping Off MeiosisQ88388233
PP4 phosphatase cooperates in recombinational DNA repair by enhancing double-strand break end resectionQ90212650
Unresolved Recombination Intermediates Cause a RAD9-Dependent Cell Cycle Arrest in Saccharomyces cerevisiaeQ90338823
Competing interaction partners modulate the activity of Sgs1 helicase during DNA end resectionQ91578516
S. cerevisiae Srs2 helicase ensures normal recombination intermediate metabolism during meiosis and prevents accumulation of Rad51 aggregatesQ91871060
Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and MeiosisQ92223579
Moving forward one step back at a time: reversibility during homologous recombinationQ92258646
Ddc2ATRIP promotes Mec1ATR activation at RPA-ssDNA tractsQ92339908
Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombinationQ92351337
The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric CancerQ92381542
Srs2 helicase prevents the formation of toxic DNA damage during late prophase I of yeast meiosisQ92552377
MUS81 Inhibition Increases the Sensitivity to Therapy Effect in Epithelial Ovarian Cancer via Regulating CyclinB PathwayQ93148848
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P577publication date2020-01-08
P1433published inGenesQ5532699
P1476titleResolvases, Dissolvases, and Helicases in Homologous Recombination: Clearing the Road for Chromosome Segregation
P478volume11

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