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P50 | author | Walter Bodmer | Q7964332 |
P2093 | author name string | Mortensen NJ | |
Wheeler JM | |||
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MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers | Q74595724 | ||
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Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53 | Q77138798 | ||
hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability | Q77804814 | ||
Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region | Q28263090 | ||
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A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer | Q28289377 | ||
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GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells | Q28292790 | ||
Mutations of GTBP in genetically unstable cells | Q28292802 | ||
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases | Q28507226 | ||
hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA | Q28610839 | ||
Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha | Q28610863 | ||
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma | Q29615026 | ||
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair | Q29615027 | ||
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer | Q29615066 | ||
Cancer epigenetics comes of age | Q29617275 | ||
Genetic instability in colorectal cancers | Q29618711 | ||
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines | Q29620526 | ||
Microsatellite instability in cancer of the proximal colon | Q29620692 | ||
Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models | Q33758794 | ||
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Hereditary factors in cancer. Study of two large midwestern kindreds | Q34241416 | ||
The mutation rate and cancer | Q34410886 | ||
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The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA. | Q34657088 | ||
The molecular basis of Turcot's syndrome | Q34662365 | ||
Cancer family “G” revisited: 1895-1970 | Q34701495 | ||
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. | Q34732921 | ||
Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1. | Q35619996 | ||
Poorly differentiated colonic adenocarcinoma, medullary type: clinical, phenotypic, and molecular characteristics. | Q35764433 | ||
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma | Q35807817 | ||
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. | Q36213486 | ||
Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins | Q36568343 | ||
APC mutations in colorectal tumors with mismatch repair deficiency | Q37383704 | ||
Sp1 binding is inhibited by (m)Cp(m)CpG methylation. | Q38343513 | ||
Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes | Q40022200 | ||
p53 and human cancers. | Q40648173 | ||
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. | Q40907031 | ||
Apoptosis induced by overexpression of hMSH2 or hMLH1. | Q40943668 | ||
Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated review | Q41127594 | ||
Mismatch repair defects in human carcinogenesis | Q41170340 | ||
An update of HNPCC (Lynch syndrome). | Q41376773 | ||
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast | Q42427955 | ||
Clues to the pathogenesis of familial colorectal cancer | Q42622043 | ||
Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas | Q42677809 | ||
Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours | Q42817159 | ||
Morphology of sporadic colorectal cancer with DNA replication errors | Q43087650 | ||
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability | Q47704165 | ||
Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability | Q47801943 | ||
Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred | Q48044118 | ||
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer | Q48084125 | ||
Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. | Q50893078 | ||
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. | Q53445992 | ||
Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. | Q53452567 | ||
A century of progress in hereditary nonpolyposis colorectal cancer (Lynch syndrome). | Q53553203 | ||
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. | Q55033068 | ||
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers | Q55480673 | ||
Cancer risk associated with germline DNA mismatch repair gene mutations | Q56813769 | ||
Microsatellite Instability in Benign Skin Lesions in Hereditary Non-Polyposis Colorectal Cancer Syndrome | Q57337202 | ||
Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog | Q57337207 | ||
Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease | Q57567959 | ||
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients | Q57570041 | ||
Interpretation of Genetic Test Results for Hereditary Nonpolyposis Colorectal Cancer | Q57591274 | ||
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines | Q57978042 | ||
Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer | Q58862199 | ||
Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer | Q61946741 | ||
The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) | Q62978412 | ||
Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours | Q63407701 | ||
Familial aggregation of tumors in the three-year experience of a population-based colorectal cancer registry | Q69648588 | ||
Cancer family syndrome. Genetic analysis of 22 Finnish kindreds | Q69990101 | ||
Extracolonic cancer in hereditary nonpolyposis colorectal cancer | Q70557907 | ||
Colorectal adenomas in surgical specimens from subjects with hereditary non-polyposis colorectal cancer | Q70789109 | ||
Microsatellite instability and alterations in the hMSH2 gene in human ovarian cancer | Q70870193 | ||
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas | Q70972741 | ||
Familial colonic cancer without antecedent polyposis | Q71317779 | ||
Diagnostic use of microsatellite instability in hereditary non-polyposis colorectal cancer | Q71520203 | ||
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers | Q71729088 | ||
Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes | Q71733947 | ||
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability | Q72127255 | ||
Immune surveillance in colorectal carcinoma | Q72293575 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | colorectal cancer | Q188874 |
DNA mismatch repair | Q2984243 | ||
colorectal carcinoma | Q25493920 | ||
P304 | page(s) | 148-153 | |
P577 | publication date | 2000-07-01 | |
P1433 | published in | Gut | Q5621669 |
P1476 | title | DNA mismatch repair genes and colorectal cancer | |
P478 | volume | 47 |
Q34777582 | 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer. |
Q35723844 | An Integrative Approach for Mapping Differentially Expressed Genes and Network Components Using Novel Parameters to Elucidate Key Regulatory Genes in Colorectal Cancer. |
Q39325874 | An Unusual Variant of Adenocarcinoma of the Left Colon Associated With Microsatellite Instability: A Case Report |
Q38328409 | Analysis of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 and MLH1-PMS1 complexes with DNA using a reversible DNA end-blocking system. |
Q84591037 | Assessment of microsatellite instability in colorectal cancer patients from Brazil |
Q44177099 | Association between Mismatch-repair Genetic variation and the Risk of Multiple Primary Cancers: A Meta-Analysis |
Q51449182 | Association between methylation in mismatch repair genes, V600E BRAF mutation and microsatellite instability in colorectal cancer patients. |
Q34270970 | Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene |
Q35026049 | Changes in apoptosis during the development of colorectal cancer: a systematic review of the literature |
Q54551065 | Clinicopathologic and molecular features of sporadic microsatellite- and chromosomal-stable colorectal cancers. |
Q45741007 | Colorectal cancer in Iran: immunohistochemical profiles of four mismatch repair proteins |
Q47149577 | Combination of primary tumor location and mismatch repair status guides adjuvant chemotherapy in stage II colon cancer |
Q83131182 | Consideration of hereditary nonpolyposis colorectal cancer in BRCA mutation-negative familial ovarian cancers |
Q92004818 | DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy |
Q34568596 | DNA mismatch repair defects: role in colorectal carcinogenesis |
Q24647002 | DNA mismatch repair: molecular mechanism, cancer, and ageing |
Q41441021 | Development of a new analog of SGK1 inhibitor and its evaluation as a therapeutic molecule of colorectal cancer |
Q38289639 | Dominant Saccharomyces cerevisiae msh6 mutations cause increased mispair binding and decreased dissociation from mispairs by Msh2-Msh6 in the presence of ATP. |
Q24793645 | Effects of camptothecin on double-strand break repair by non-homologous end-joining in DNA mismatch repair-deficient human colorectal cancer cell lines |
Q36436073 | Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair |
Q40146719 | Epidemiology of colorectal cancer: the 21-year experience of a specialised registry. |
Q37061792 | Epigenetics and colorectal cancer pathogenesis |
Q39736506 | Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers |
Q93163404 | Establishment and characterization of 18 human colorectal cancer cell lines |
Q36265836 | Evaluation of microsatellite instability in tumors of central nervous system: A pilot study |
Q39108890 | Genetic aberrations in childhood acute lymphoblastic leukaemia: application of high-density single nucleotide polymorphism array. |
Q36696628 | Genetic testing among high-risk individuals in families with hereditary nonpolyposis colorectal cancer. |
Q57737908 | Genotype-phenotype correlations in individuals with a founder mutation in the MLH1 gene and hereditary non-polyposis colorectal cancer |
Q38730390 | Helicobacter pylori infection modulates the expression of miRNAs associated with DNA mismatch repair pathway. |
Q35571225 | Hereditary nonpolyposis colorectal cancer: preventive management |
Q35562099 | Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects |
Q47375648 | INK4a-ARF alterations in Barrett's epithelium, intraepithelial neoplasia and Barrett's adenocarcinoma |
Q35594804 | INK4a-ARF alterations in liver cell adenoma |
Q46967606 | INK4a-ARF alterations in liver cell adenoma |
Q90113851 | Immunotherapy, Inflammation and Colorectal Cancer |
Q43429867 | Impact of colonoscopic screening in male and female Lynch syndrome carriers with an MSH2 mutation |
Q53676958 | Mechanisms and anticarcinogenic effects of diet-related apoptosis in the intestinal mucosa. |
Q33947093 | Methylation analysis of MLH1 improves the selection of patients for genetic testing in Lynch syndrome. |
Q34378429 | Methylation and colorectal cancer |
Q36776983 | Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series |
Q36779731 | Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications |
Q44644581 | Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma. |
Q35234577 | Mismatch repair genes expression defects & association with clinicopathological characteristics in colorectal carcinoma |
Q55224542 | Mismatch repair protein expression in patients with stage II and III sporadic colorectal cancer. |
Q33758325 | Mismatch repair proteins are activators of toxic responses to chromium-DNA damage |
Q35760529 | Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer |
Q28508841 | Mitochondrial dysfunction and increased sensitivity to excitotoxicity in mice deficient in DNA mismatch repair |
Q28081871 | Mouse models of colorectal cancer as preclinical models |
Q28506656 | Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner |
Q26769850 | Pharmacologic resistance in colorectal cancer: a review |
Q34583335 | Prevention and chemoprevention of colorectal neoplasms |
Q92287784 | Prognostic Relevance of SFRP1 Gene Promoter Methylation in Colorectal Carcinoma |
Q43006449 | Proximal and progressive: adenomas in HNPCC. |
Q34657323 | Review of histopathological and molecular prognostic features in colorectal cancer |
Q57784305 | Stochastic Processes and Component Plasticity Governing DNA Mismatch Repair |
Q35969977 | Symptomatic presentation of early colorectal cancer |
Q37172151 | The genomics of colorectal cancer: state of the art. |
Q44511151 | The phenotypic expression of three MSH2 mutations in large Newfoundland families with Lynch syndrome |
Q57190619 | Trinucleotide Repeat Expansion Diseases, RNAi, and Cancer |
Q37507301 | Tumour MLH1 promoter region methylation testing is an effective prescreen for Lynch Syndrome (HNPCC). |
Q33675252 | Utility of p16 immunohistochemistry for the identification of Lynch syndrome |
Q34619340 | When is molecular genetic testing for colorectal cancer indicated? |
Q33726141 | miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2. |
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