DNA mismatch repair genes and colorectal cancer

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DNA mismatch repair genes and colorectal cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1136/GUT.47.1.148
P932PMC publication ID1727951
P698PubMed publication ID10861278
P5875ResearchGate publication ID12457982

P50authorWalter BodmerQ7964332
P2093author name stringMortensen NJ
Wheeler JM
P2860cites workUbiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesisQ22122362
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The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairsQ27930815
Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complexQ27932428
Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.Q27934985
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
Mutation of a mutL homolog in hereditary colon cancerQ28114939
Genetic instabilities in human cancersQ28131826
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancerQ28253384
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancerQ28256988
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancerQ28257360
Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patientsQ72313890
Unicryptal loss of heterozygosity in hereditary non-polyposis colorectal cancerQ72634694
Genomic instability occurs in colorectal carcinomas but not in adenomasQ72649470
Genomic instability in colorectal cancer: relationship to clinicopathological variables and family historyQ72657539
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Association between CpG island methylation and microsatellite instability in colorectal cancerQ73622839
Microsatellite instability in human solid tumorsQ74546889
MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancersQ74595724
Excision repair invades the territory of mismatch repairQ74610856
Diagnosis of hereditary non-polyposis colorectal cancerQ74802565
Genetics of colonic cancerQ77096087
Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53Q77138798
hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instabilityQ77804814
Methylation-sensitive sequence-specific DNA binding by the c-Myc basic regionQ28263090
Genetic mapping of a locus predisposing to human colorectal cancerQ28268634
Biochemistry and genetics of eukaryotic mismatch repairQ28282377
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancerQ28289377
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor CellsQ28292781
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cellsQ28292790
Mutations of GTBP in genetically unstable cellsQ28292802
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferasesQ28507226
hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNAQ28610839
Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalphaQ28610863
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinomaQ29615026
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
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Cancer epigenetics comes of ageQ29617275
Genetic instability in colorectal cancersQ29618711
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell linesQ29620526
Microsatellite instability in cancer of the proximal colonQ29620692
Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical modelsQ33758794
1998 Runme Shaw Memorial Lecture: somatic evolution of cancerQ33781124
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The mutation rate and cancerQ34410886
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA.Q34657088
The molecular basis of Turcot's syndromeQ34662365
Cancer family “G” revisited: 1895-1970Q34701495
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.Q34732921
Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1.Q35619996
Poorly differentiated colonic adenocarcinoma, medullary type: clinical, phenotypic, and molecular characteristics.Q35764433
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinomaQ35807817
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.Q36213486
Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteinsQ36568343
APC mutations in colorectal tumors with mismatch repair deficiencyQ37383704
Sp1 binding is inhibited by (m)Cp(m)CpG methylation.Q38343513
Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genesQ40022200
p53 and human cancers.Q40648173
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.Q40907031
Apoptosis induced by overexpression of hMSH2 or hMLH1.Q40943668
Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated reviewQ41127594
Mismatch repair defects in human carcinogenesisQ41170340
An update of HNPCC (Lynch syndrome).Q41376773
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Clues to the pathogenesis of familial colorectal cancerQ42622043
Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomasQ42677809
Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumoursQ42817159
Morphology of sporadic colorectal cancer with DNA replication errorsQ43087650
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instabilityQ47704165
Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instabilityQ47801943
Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindredQ48044118
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancerQ48084125
Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.Q50893078
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.Q53445992
Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer.Q53452567
A century of progress in hereditary nonpolyposis colorectal cancer (Lynch syndrome).Q53553203
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.Q55033068
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancersQ55480673
Cancer risk associated with germline DNA mismatch repair gene mutationsQ56813769
Microsatellite Instability in Benign Skin Lesions in Hereditary Non-Polyposis Colorectal Cancer SyndromeQ57337202
Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dogQ57337207
Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the DiseaseQ57567959
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patientsQ57570041
Interpretation of Genetic Test Results for Hereditary Nonpolyposis Colorectal CancerQ57591274
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda GuidelinesQ57978042
Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancerQ58862199
Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal CancerQ61946741
The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)Q62978412
Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumoursQ63407701
Familial aggregation of tumors in the three-year experience of a population-based colorectal cancer registryQ69648588
Cancer family syndrome. Genetic analysis of 22 Finnish kindredsQ69990101
Extracolonic cancer in hereditary nonpolyposis colorectal cancerQ70557907
Colorectal adenomas in surgical specimens from subjects with hereditary non-polyposis colorectal cancerQ70789109
Microsatellite instability and alterations in the hMSH2 gene in human ovarian cancerQ70870193
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomasQ70972741
Familial colonic cancer without antecedent polyposisQ71317779
Diagnostic use of microsatellite instability in hereditary non-polyposis colorectal cancerQ71520203
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancersQ71729088
Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genesQ71733947
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instabilityQ72127255
Immune surveillance in colorectal carcinomaQ72293575
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
DNA mismatch repairQ2984243
colorectal carcinomaQ25493920
P304page(s)148-153
P577publication date2000-07-01
P1433published inGutQ5621669
P1476titleDNA mismatch repair genes and colorectal cancer
P478volume47

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