| scholarly article | Q13442814 |
| P356 | DOI | 10.1126/SCIENCE.275.5302.967 |
| P698 | PubMed publication ID | 9020077 |
| P50 | author | Manuel Perucho | Q30539723 |
| P2093 | author name string | Li Y | |
| Yamamoto H | |||
| Reed JC | |||
| Sawai H | |||
| Ionov Y | |||
| Rampino N | |||
| P2860 | cites work | Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis | Q22122362 |
| Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death | Q24312211 | ||
| Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability | Q24319995 | ||
| A genetic model for colorectal tumorigenesis | Q27860582 | ||
| Mismatch repair: mechanisms and relationship to cancer susceptibility | Q28271480 | ||
| Tumor suppressor p53 is a direct transcriptional activator of the human bax gene | Q28306186 | ||
| Bax-deficient mice with lymphoid hyperplasia and male germ cell death | Q28589360 | ||
| Regulators of cell death | Q29042165 | ||
| Microsatellite instability in cancer of the proximal colon | Q29620692 | ||
| Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6 | Q29622924 | ||
| Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday | Q34229913 | ||
| p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches | Q38294077 | ||
| Defects in replication fidelity of simple repeated sequences reveal a new mutator mechanism for oncogenesis | Q40431209 | ||
| Regulation of lymphocyte survival by the bcl-2 gene family | Q40444925 | ||
| Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives | Q40482404 | ||
| The tumor suppressor p53. | Q40838644 | ||
| The tumor suppressor genes | Q40856821 | ||
| Life, death, and the pursuit of apoptosis. | Q40942974 | ||
| Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation | Q46049171 | ||
| Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. | Q53452567 | ||
| Frameshift mutator mutations | Q57978058 | ||
| P433 | issue | 5302 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phenotype | Q104053 |
| microsatellite | Q265193 | ||
| P1104 | number of pages | 3 | |
| P304 | page(s) | 967-969 | |
| P577 | publication date | 1997-02-01 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. | |
| P478 | volume | 275 |
| Q44401682 | 5‐Fluorouracil efficiently enhanced apoptosis induced by adenovirus‐mediated transfer of caspase‐8 in DLD‐1 colon cancer cells |
| Q64379556 | A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells |
| Q24303520 | A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells |
| Q37701535 | A mononucleotide repeat in PRRT2 is an important, frequent target of mismatch repair deficiency in cancer. |
| Q40015731 | A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner |
| Q40923540 | A photosensitising adenovirus for photodynamic therapy |
| Q33816818 | A portrait of the Bcl-2 protein family: life, death, and the whole picture |
| Q36017683 | A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability |
| Q78141302 | A somatic BRCA2 mutation in RER+ endometrial carcinomas that specifically deletes the amino-terminal transactivation domain |
| Q35138968 | A time to kill: targeting apoptosis in cancer |
| Q24321639 | A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition |
| Q38305678 | Abnormal intracellular localization of Bax with a normal membrane anchor domain in human lung cancer cell lines |
| Q74601084 | Absence of intragenic mismatch mutations in small cell lung cancers with microsatellite instability |
| Q73477519 | Absence of microsatellite instability in transitional cell carcinoma of the bladder |
| Q73003043 | Accelerated apoptosis and low bcl-2 expression associated with neuroendocrine differentiation predict shortened survival in operated large cell carcinoma of the lung |
| Q35753544 | Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences |
| Q41020572 | Accumulation of genetic alterations and their significance in each primary human cancer and cell line |
| Q44800956 | Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis |
| Q28366563 | Activation and activities of the p53 tumour suppressor protein |
| Q40120481 | Activation of glycogen synthase kinase 3beta promotes the intermolecular association of tau. The use of fluorescence resonance energy transfer microscopy |
| Q44798254 | Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo |
| Q34133568 | Ageing and the mismatch repair system |
| Q35567264 | Alterations in the apoptotic machinery and their potential role in anticancer drug resistance |
| Q74434710 | Alterations of repeated sequences in 5' upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome |
| Q36637607 | Alternative genetic pathways in colorectal carcinogenesis. |
| Q38968877 | Alternative splicing and cell survival: from tissue homeostasis to disease |
| Q39744515 | Amplification of repeat-containing transcribed sequences (ARTS): a transcriptome fingerprinting strategy to detect functionally relevant microsatellite mutations in cancer |
| Q37448192 | An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression |
| Q35700262 | An introduction to the molecular mechanisms of apoptosis |
| Q42502670 | Analysis of p53 and BAX mutations, loss of heterozygosity, p53 and BCL2 expression and apoptosis in basal cell carcinoma in Korean patients |
| Q48587126 | Anaplastic oligoastrocytoma in Turcot syndrome |
| Q27009170 | Animal models of colorectal cancer |
| Q34001641 | Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer |
| Q35058958 | Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design |
| Q31888075 | Antioxidants enhance the susceptibility of colon carcinoma cells to 5-fluorouracil by augmenting the induction of the bax protein |
| Q34532325 | Apo2L/TRAIL and its death and decoy receptors |
| Q40636941 | Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells |
| Q33227197 | Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent. |
| Q58327271 | Apoptosis and cancer |
| Q34124148 | Apoptosis and cancer: strategies for integrating programmed cell death |
| Q37641452 | Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype |
| Q34214558 | Apoptosis and its clinical impact |
| Q41737530 | Apoptosis by p53: mechanisms, regulation, and clinical implications |
| Q33846227 | Apoptosis in cancer |
| Q40127987 | Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa. |
| Q34803681 | Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression |
| Q34395580 | Apoptosis regulators and their role in tumorigenesis |
| Q28593886 | Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis |
| Q41759481 | Apoptosis, cancer and cancer therapy. |
| Q34520432 | Apoptosis: a link between cancer genetics and chemotherapy |
| Q35088734 | Apoptotic cell signaling in cancer progression and therapy |
| Q36226739 | Apoptotic pathways and therapy resistance in human malignancies |
| Q34088809 | Application of molecular diagnostics for the detection of Lynch syndrome |
| Q35047698 | Ardipusilloside I induces apoptosis by regulating Bcl-2 family proteins in human mucoepidermoid carcinoma Mc3 cells |
| Q40700286 | Association of a novel single nucleotide polymorphism, G(-248)A, in the 5'-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance |
| Q61814935 | Augmented antitumor activity of 5-fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells |
| Q38720813 | Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma |
| Q54455470 | BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia. |
| Q55033193 | BAT-26 identifies sporadic colorectal cancers with mutator phenotype: a correlative study with clinico-pathological features and mutations in mismatch repair genes. |
| Q40702714 | BAX and BAK mediate p53-independent suppression of tumorigenesis |
| Q47753304 | BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability |
| Q35673934 | BAX pro-apoptotic gene alterations in repeated pregnancy loss |
| Q27002044 | BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore |
| Q36463059 | BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. |
| Q35079498 | BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak |
| Q45873402 | Bax induction activates apoptotic cascade via mitochondrial cytochrome c release and Bax overexpression enhances apoptosis induced by chemotherapeutic agents in DLD-1 colon cancer cells |
| Q36671241 | Bax is essential for mitochondrion-mediated apoptosis but not for cell death caused by photodynamic therapy |
| Q28513038 | Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis |
| Q33212700 | Bax-dependent regulation of Bak by voltage-dependent anion channel 2. |
| Q40077808 | Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation |
| Q47723057 | Bax. The pro-apoptotic Bcl-2 family member, Bax. |
| Q37424404 | BaxΔ2 Family Alternative Splicing Salvages Bax Microsatellite-Frameshift Mutations. |
| Q36298500 | BaxΔ2 is a novel bax isoform unique to microsatellite unstable tumors |
| Q42829391 | Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer |
| Q39895250 | Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells |
| Q34780626 | Bcl-2 family members as prognostic indicators in AML. |
| Q37310180 | Bcl-2 family proteins and cancer |
| Q36508817 | Bcl-2-family proteins and hematologic malignancies: history and future prospects |
| Q37373448 | Bcl2 family proteins in carcinogenesis and the treatment of cancer. |
| Q41896356 | Beyond Genetics in Glioma Pathways: The Ever-Increasing Crosstalk between Epigenomic and Genomic Events |
| Q38295926 | Bias in detection of instability of the (C)8 mononucleotide repeat of MSH6 in tumours from HNPCC patients |
| Q38326924 | Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis |
| Q34558159 | Biology and genetics of colorectal cancer |
| Q34669618 | Biology of colorectal cancer |
| Q91754859 | Biomarker-guided therapy for colorectal cancer: strength in complexity |
| Q38064740 | Biomarkers in early-stage colorectal cancer: ready for prime time? |
| Q24648909 | Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members |
| Q39711042 | Both microsatellite length and sequence context determine frameshift mutation rates in defective DNA mismatch repair |
| Q42427792 | Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. |
| Q40682509 | Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax. |
| Q36786062 | Cancer dormancy: lessons from a B cell lymphoma and adenocarcinoma of the prostate |
| Q38125424 | Cancer immunogenicity, danger signals, and DAMPs: what, when, and how? |
| Q28066868 | Cancer's Achilles' Heel: Apoptosis and Necroptosis to the Rescue |
| Q39547630 | Candidate driver genes in microsatellite-unstable colorectal cancer |
| Q35078813 | Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis |
| Q28253670 | Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics |
| Q33602258 | Carcinogenesis and natural selection: a new perspective to the genetics and epigenetics of colorectal cancer |
| Q34194253 | Carcinogenesis in the GI tract: from morphology to genetics and back again |
| Q33911332 | Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma |
| Q38827694 | Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner |
| Q53631481 | Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas. |
| Q33674213 | Cellular stress responses: cell survival and cell death |
| Q37238532 | Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways |
| Q34636547 | Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc(-/+) mice |
| Q36693771 | Chemotherapeutic implications in microsatellite unstable colorectal cancer |
| Q38094098 | Chemotherapy of MMR-deficient colorectal cancer |
| Q48032941 | Chromosomal assignment of loci susceptible to replication errors by radiation hybrid mapping |
| Q36617839 | Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes |
| Q46348708 | Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair |
| Q90386392 | Circulating DNA as prognostic biomarker in patients with advanced hepatocellular carcinoma: a translational exploratory study from the SORAMIC trial |
| Q36699559 | Classification of colorectal cancer based on correlation of clinical, morphological and molecular features |
| Q33990921 | Clinical relevance of microsatellite instability in colorectal cancer |
| Q57426147 | Clinical significance of mutator phenotype and chromosome 17p and 18q allelic loss in gastric cancer |
| Q35027793 | Clinical update of Ad-p53 gene therapy for lung cancer |
| Q54551065 | Clinicopathologic and molecular features of sporadic microsatellite- and chromosomal-stable colorectal cancers. |
| Q28143345 | Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants |
| Q35837213 | Colon cancer: genomics and apoptotic events |
| Q34768418 | Colorectal cancer "methylator phenotype": fact or artifact? |
| Q28240136 | Colorectal cancer: genetics of development and metastasis |
| Q33652932 | Colorectal cancer: molecules and populations |
| Q37183760 | Colorectal carcinogenesis: Review of human and experimental animal studies |
| Q35029022 | Colorectal polyps and other precursor lesions. Need for an expanded view |
| Q35097421 | Colorectal pretumor progression before and after loss of DNA mismatch repair |
| Q33186848 | Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability |
| Q53385235 | Comparative analysis of mutation frequency of coding and non coding short mononucleotide repeats in mismatch repair deficient colorectal cancers. |
| Q24650948 | Comparative genomics and molecular dynamics of DNA repeats in eukaryotes |
| Q80281973 | Complete activation of Bax by a single site mutation |
| Q33383866 | Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample |
| Q36973617 | Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers |
| Q73212113 | Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells |
| Q48328376 | Conservation of mononucleotide repeats within 3' and 5' untranslated regions and their instability in MSI-H colorectal cancer |
| Q42009519 | Controlling TRAIL-mediated caspase-3 activation. |
| Q60921028 | Cordycepin induces Bax‑dependent apoptosis in colorectal cancer cells |
| Q51030548 | Correlation of bcl-2 and bax with apoptosis in human pituitary adenomas. |
| Q90737510 | Correlations between microsatellite instability and the biological behaviour of tumours |
| Q24672170 | CpG island methylator phenotype in colorectal cancer |
| Q78066993 | Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer |
| Q36672197 | Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation |
| Q37020817 | DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers |
| Q36167430 | DNA damage-induced programmed cell death: potential roles in germ cell development |
| Q37790063 | DNA fingerprinting techniques for the analysis of genetic and epigenetic alterations in colorectal cancer |
| Q35019579 | DNA methylation in cancer and ageing |
| Q35360590 | DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. |
| Q74701340 | DNA mismatch repair and cancer |
| Q34568596 | DNA mismatch repair defects: role in colorectal carcinogenesis |
| Q78054861 | DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: a molecular case report |
| Q33947053 | DNA mismatch repair genes and colorectal cancer |
| Q41536289 | DNA mismatch repair in mammals: role in disease and meiosis |
| Q28589698 | Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo |
| Q28217065 | Death and anti-death: tumour resistance to apoptosis |
| Q35743149 | Death receptors in chemotherapy and cancer |
| Q37921609 | Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases |
| Q38115674 | Decoding and unlocking the BCL-2 dependency of cancer cells |
| Q42040567 | Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells |
| Q38320932 | Defective DNA mismatch repair and XRCC2 mutation in uterine carcinosarcomas |
| Q53315455 | Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia. |
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| Q99349998 | Defining the susceptibility of colorectal cancers to BH3-mimetic compounds |
| Q44795441 | Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events |
| Q34264428 | Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells |
| Q43955963 | Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities |
| Q28277027 | Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability |
| Q34569214 | Diagnosis of microsatellite instability-positive colorectal cancer |
| Q37235042 | Differences and evolution of the methods for the assessment of microsatellite instability |
| Q50915480 | Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors. |
| Q28592891 | Different mutator phenotypes in Mlh1- versus Pms2-deficient mice |
| Q34391153 | Differential colorectal carcinogenesis: Molecular basis and clinical relevance |
| Q31039347 | Differential expression of the mismatch repair gene hMSH2 in malignant prostate tissue is associated with cancer recurrence |
| Q43902939 | Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells |
| Q52124747 | Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability. |
| Q28141250 | Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers |
| Q30353924 | Direct Activation of Bax Protein for Cancer Therapy |
| Q33991388 | Direct selection for mutators in Escherichia coli. |
| Q37319386 | Directing cancer cells to self-destruct with pro-apoptotic receptor agonists |
| Q38782374 | Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise. |
| Q57272486 | Dissecting the apoptotic mechanisms of chemotherapeutic drugs and lymphocytes to design effective anticancer therapies |
| Q48156509 | Distinct functional domains of PNMA5 mediate protein-protein interaction, nuclear localization, and apoptosis signaling in human cancer cells |
| Q34615912 | Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability |
| Q35877059 | Don't stop for repairs in a war zone: Darwinian evolution unites genes and environment in cancer development |
| Q33912974 | Down-regulation of epidermal growth factor receptor by selective expansion of a 5'-end regulatory dinucleotide repeat in colon cancer with microsatellite instability |
| Q36625664 | Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. |
| Q34658574 | Dysregulation of apoptosis genes in hematopoietic malignancies. |
| Q64229234 | Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells |
| Q36584253 | Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas |
| Q38398064 | Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment. |
| Q35747961 | Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability |
| Q37236178 | Endometrial cancer as a familial tumor: pathology and molecular carcinogenesis (review). |
| Q37061792 | Epigenetics and colorectal cancer pathogenesis |
| Q36526103 | Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells |
| Q41655689 | Errors of homeostasis and deregulated apoptosis |
| Q34615970 | Escherichia coli strains (ndk) lacking nucleoside diphosphate kinase are powerful mutators for base substitutions and frameshifts in mismatch-repair-deficient strains |
| Q40908590 | Establishment and characterization of seven human renal cell carcinoma cell lines |
| Q38130013 | Evading apoptosis in cancer |
| Q45290287 | Evaluation of some cell death features by real time real space microscopy |
| Q61196038 | Evaluation of the replication error phenotype in relation to molecular and clinicopathological features in hereditary and early onset colorectal cancer |
| Q46901189 | Evidence for apoptosis of the majority of T cells activated in vitro with Actinobacillus actinomycetemcomitans |
| Q44412165 | Evodiamine, a constituent of Evodiae Fructus, induces anti‐proliferating effects in tumor cells |
| Q34622521 | Evolution of colorectal cancer: change of pace and change of direction. |
| Q77619057 | Excess of hMLH1 germline mutations in Swiss families with hereditary non-polyposis colorectal cancer |
| Q34428897 | Exploiting DNA mismatch repair deficiency as a therapeutic strategy |
| Q43692641 | Expression of apoptosis regulating proteins identifies stage II and III colon cancer patients with high risk of recurrence |
| Q28359548 | Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer |
| Q31003475 | Expression of bcl-2, bax and bcl-xl in human gliomas: a re-appraisal. |
| Q53394313 | Expression of early lung cancer detection marker: hnRNP-A2/B1 and its relation to microsatellite alteration in non-small cell lung cancer. |
| Q77925474 | Expression of p53, p21/waf, bcl-2, bax, Rb and Ki67 proteins in colorectal adenocarcinomas |
| Q46550944 | Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract |
| Q50639647 | Expression of the proapoptotic protein Bax is reduced in bronchial mucous cells of asthmatic subjects. |
| Q81437106 | Expressional and mutational analysis of pro-apoptotic Bcl-2 member PUMA in hepatocellular carcinomas |
| Q52826936 | Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. |
| Q36558024 | Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy |
| Q30799362 | Fabrication of DNA microarrays onto polymer substrates using UV modification protocols with integration into microfluidic platforms for the sensing of low-abundant DNA point mutations |
| Q39457791 | Flanking nucleotide specificity for DNA mismatch repair-deficient frameshifts within activin receptor 2 (ACVR2). |
| Q53374898 | Frameshift Mutations in the Bax Gene Are Not Involved in Development of Ovarian Endometrioid Carcinoma |
| Q47791002 | Frameshift mismatch recognition by the human MutS alpha complex |
| Q55092553 | Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability. |
| Q33791245 | Frameshift mutation, microsatellites and mismatch repair |
| Q46898106 | Frameshift mutations at mononucleotide repeats in RAD50 recombinational DNA repair gene in colorectal cancers with microsatellite instability |
| Q57978027 | Frameshift mutations in Fas, Apaf-1 and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype |
| Q24337018 | Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability |
| Q77768810 | Frameshift mutations of human gastrin receptor gene (hGARE) in gastrointestinal cancers with microsatellite instability |
| Q40801080 | Frameshift peptide-derived T-cell epitopes: a source of novel tumor-specific antigens |
| Q33949281 | Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer |
| Q57978049 | Frequent alterations in gene expression in colon tumor cells of the microsatellite mutator phenotype |
| Q40734946 | Frequent and multiple mutations at minisatellite loci in sporadic human colorectal and gastric cancers--possible mechanistic differences from microsatellite instability in cancer cells |
| Q22253396 | Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines |
| Q53966209 | Frequent mutations of Fas gene in nasal NK/T cell lymphoma. |
| Q37010058 | Frequent truncating mutation of TFAM induces mitochondrial DNA depletion and apoptotic resistance in microsatellite-unstable colorectal cancer |
| Q33952944 | Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype. |
| Q40462587 | G125A single-nucleotide polymorphism in the human BAX promoter affects gene expression. |
| Q73602630 | Gastric cancer with mutator phenotype: molecular bases and mechanisms of progression |
| Q47673133 | Gastrointestinal Malignancy: Genetic Implications to Clinical Applications |
| Q33599177 | Gastrointestinal polyposis syndromes |
| Q43981220 | Gene-specific oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa |
| Q55476452 | Genetic alterations in pediatric high-grade astrocytomas. |
| Q74234550 | Genetic alterations of sporadic colorectal cancer with microsatellite instability, especially characteristics of primary multiple colorectal cancers |
| Q33961252 | Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutations |
| Q34177743 | Genetic and epigenetic changes in stomach cancer |
| Q42726260 | Genetic instability and the mutator phenotype. Studies in ulcerative colitis |
| Q28214754 | Genetic instability in human mismatch repair deficient cancers |
| Q73898283 | Genetic instability in intestinal metaplasia is a frequent event leading to well-differentiated early adenocarcinoma of the stomach |
| Q33711610 | Genetic pathways in colorectal and other cancers |
| Q57337198 | Genetic pathways in colorectal and other cancers |
| Q31464606 | Genetic predisposition and somatic diversification in tumor development and progression |
| Q37523207 | Genetic prognostic and predictive markers in colorectal cancer |
| Q24670186 | Genetic reconstruction of individual colorectal tumor histories |
| Q42121380 | Genetically-directed Sparse Neuronal Labeling in BAC Transgenic Mice through Mononucleotide Repeat Frameshift |
| Q80946836 | Genetics of colorectal cancer |
| Q57977995 | Genetics supersedes epigenetics in colon cancer phenotype |
| Q33724516 | Genomic amplification of the human DHFR/MSH3 locus remodels mismatch recognition and repair activities |
| Q33836026 | Genomic and epigenetic instability in colorectal cancer pathogenesis |
| Q24792044 | Genomic approaches to research in pulmonary hypertension |
| Q28369693 | Genomic imbalance in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
| Q36474291 | Genomic instability of murine hepatocellular carcinomas with low and high metastatic capacities |
| Q36115550 | Genomic loci susceptible to replication errors in cancer cells |
| Q42013009 | Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas |
| Q42856984 | Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer |
| Q57978009 | Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype |
| Q39305823 | Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer. |
| Q40810320 | Growth inhibition due to complementation of transforming growth factor-beta receptor type II-defect by human chromosome 3 transfer in human colorectal carcinoma cells |
| Q41056926 | Growth inhibition of DU-145 prostate cancer cells by a Bcl-2 antisense oligonucleotide is enhanced by N-(2-hydroxyphenyl)all-trans retinamide |
| Q56928447 | Hereditary breast cancer |
| Q73167197 | Hereditary non-polyposis colorectal cancer associated with disseminated superficial porokeratosis. Microsatellite instability in skin tumours |
| Q34316225 | Hereditary non-polyposis colorectal cancer syndrome: combined risk of gastrointestinal and gynaecological cancer |
| Q34480707 | Hereditary ovarian cancer: not only BRCA 1 and 2 genes. |
| Q53414631 | Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability. |
| Q42850802 | Histopathological evaluation of apoptosis in cancer |
| Q42284928 | History and pathogenesis of lynch syndrome |
| Q35032556 | Hormone-refractory prostate cancer: a multi-step and multi-event process |
| Q34290061 | How apoptosis is regulated, and what goes wrong in cancer |
| Q39762451 | Human papillomavirus type 16 E5 protein inhibits hydrogen-peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells |
| Q36812749 | Human postmeiotic segregation 2 exhibits biased repair at tetranucleotide microsatellite sequences |
| Q46591528 | Hydroxyurea (HU)-induced apoptosis in the mouse fetal lung |
| Q35029017 | Hypermethylation pathways to colorectal cancer. Implications for prevention and detection |
| Q34603856 | Hypermutability in carcinogenesis |
| Q37011260 | Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance |
| Q28215990 | Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability |
| Q40619350 | Identification of an HLA-A0201-restricted CTL epitope generated by a tumor-specific frameshift mutation in a coding microsatellite of the OGT gene |
| Q34106765 | Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated by the (-1) frame of U79260(FTO). |
| Q52826323 | Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines. |
| Q34162250 | Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability |
| Q40211704 | Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells |
| Q34311701 | Immunogenic cell death and DAMPs in cancer therapy |
| Q34662777 | Immunohistochemical and mutational analysis of FLASH in gastric carcinomas |
| Q36292668 | Immunohistochemical detection of p53 and Bcl-2 in colorectal carcinoma: no evidence for prognostic significance |
| Q28068788 | Immunotherapy in human colorectal cancer: Challenges and prospective |
| Q35204983 | Impact of proapoptotic proteins Bax and Bak in tumor progression and response to treatment |
| Q33180786 | Impaired BAX protein expression in breast cancer: mutational analysis of the BAX and the p53 gene |
| Q36107605 | Implication of microsatellite instability in human gastric cancers |
| Q40988373 | In situ detection of frameshift mutations in mouse cells |
| Q40575996 | Inactivating mutations of proapoptotic Bad gene in human colon cancers |
| Q46803219 | Inactivation of Id-1 in prostate cancer cells: A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathway |
| Q29615026 | Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma |
| Q51330907 | Increased susceptibility to apoptosis in CD45(+) myeloma cells accompanied by the increased expression of VDAC1. |
| Q35043420 | Induction of apoptosis in cancer: new therapeutic opportunities |
| Q41750576 | Influence of BCL2-938C>A and BAX-248G>A promoter polymorphisms in the development of AML: case-control study from South India. |
| Q77344025 | Infrequent bax gene mutations in B-cell lymphomas |
| Q74073108 | Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines |
| Q45880920 | Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivo |
| Q51970952 | Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. |
| Q40845540 | Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis |
| Q54593462 | Interleukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability. |
| Q38020473 | Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer. |
| Q57623629 | Investigation of bax, bcl-2, bcl-x and p53 gene polymorphisms in multiple sclerosis |
| Q92095889 | Involvement of proapoptotic genes in autophagic cell death induced by irradiation |
| Q73444099 | K-ras mutations in endometrial carcinomas with microsatellite instability |
| Q35223910 | Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody |
| Q31136038 | Ku70 suppresses the apoptotic translocation of Bax to mitochondria. |
| Q55343224 | Learning on the Fly: The Interplay between Caspases and Cancer. |
| Q38440406 | Loss of BCL-2 in the progression of oral cancer is not attributable to mutations |
| Q37505528 | Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors. |
| Q47895480 | Lymphoma development in Bax transgenic mice is inhibited by Bcl-2 and associated with chromosomal instability. |
| Q36259687 | Lynch syndrome (hereditary non-polyposis colorectal cancer): current concepts and approaches to management |
| Q24337383 | MAP-1 is a mitochondrial effector of Bax. |
| Q38276483 | Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma. |
| Q28145150 | Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer |
| Q28473094 | Mathematical modelling of cell-fate decision in response to death receptor engagement |
| Q49830082 | Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins. |
| Q34224865 | Mechanisms of action of flavopiridol |
| Q56609201 | Mechanisms of apoptosis |
| Q35866050 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis |
| Q77900186 | Metabolism of 1alpha,25(OH)2D3 and its 20-epi analog integrates clonal expansion, maturation and apoptosis during HL-60 cell differentiation |
| Q24538673 | Metapopulation dynamics and spatial heterogeneity in cancer |
| Q35142162 | Methods for screening tumors for p53 status and therapeutic exploitation. |
| Q34378429 | Methylation and colorectal cancer |
| Q35550260 | Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans |
| Q56602274 | Microsatellite Instability in the Adenoma-Carcinoma Sequence of the Stomach |
| Q77531679 | Microsatellite alterations and p53, TGFbetaRII, IGFIIR and BAX mutations in sporadic non-small-cell lung cancer |
| Q74141755 | Microsatellite alterations and target gene mutations in the early stages of multiple gastric cancer |
| Q38307980 | Microsatellite instability and alteration of E2F-4 gene in adenosquamous and squamous cell carcinomas of the stomach |
| Q54935980 | Microsatellite instability and frameshift mutations in the Bax gene in hereditary nonpolyposis colorectal carcinoma. |
| Q63966362 | Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract |
| Q35753493 | Microsatellite instability and mutation of DNA mismatch repair genes in gliomas. |
| Q73719421 | Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma |
| Q55475900 | Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene. |
| Q31400528 | Microsatellite instability associated with hepatocarcinogenesis |
| Q53436328 | Microsatellite instability in Japanese hereditary non-polyposis colorectal cancer does not induce mutation of a simple repeat sequence of the bax gene. |
| Q36338134 | Microsatellite instability in gastrointestinal tract cancers: a brief update |
| Q35557578 | Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract |
| Q73758307 | Microsatellite instability in squamous cell carcinoma of head and neck from the Indian patient population |
| Q53400371 | Microsatellite instability in synchronous gastric carcinomas. |
| Q58493764 | Microsatellite instability induced by hydrogen peroxide in Escherichia coli |
| Q48667067 | Microsatellite instability is associated with a better prognosis for gastric cancer patients after curative surgery |
| Q54053592 | Microsatellite instability is associated with genetic alteration but not with low levels of expression of the human mismatch repair proteins hMSH2 and hMLH1. |
| Q73653671 | Microsatellite instability is associated with the loss of apoptosis in ductal breast carcinomas |
| Q64101180 | Microsatellite instability is inversely associated with type 2 diabetes mellitus in colorectal cancer |
| Q53360291 | Microsatellite instability of selective target genes in HNPCC-associated colon adenomas. |
| Q37157691 | Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803. |
| Q36618286 | Microsatellite instability, Epstein-Barr virus, mutation of type II transforming growth factor beta receptor and BAX in gastric carcinomas in Hong Kong Chinese |
| Q53313816 | Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B. |
| Q38363519 | Microsatellite instability: an update |
| Q34217505 | Microsatellite instability: application in hereditary non-polyposis colorectal cancer. |
| Q54102997 | Microsatellite instability: impact on cancer progression in proximal and distal colorectal cancers. |
| Q78651262 | Microsatellite mutations of transforming growth factor-beta receptor type II and caspase-5 occur in human precursor T-cell lymphoblastic lymphomas/leukemias in vivo but are not associated with hMSH2 or hMLH1 promoter methylation |
| Q43864989 | Milestones of Lynch syndrome: 1895-2015. |
| Q37566211 | Mimicking the BH3 domain to kill cancer cells |
| Q36596138 | Minisatellite instability in severe combined immunodeficiency mouse cells |
| Q35129256 | Mismatch repair proficiency and in vitro response to 5-fluorouracil |
| Q35225280 | Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters |
| Q58690234 | Mitochondrial Markers for Cancer: Relevance to Diagnosis, Therapy, and Prognosis and General Understanding of Malignant Disease Mechanisms |
| Q37700096 | Mitochondrial signaling in cell death via the Bcl-2 family |
| Q28586588 | Mlh1 mediates tissue-specific regulation of mitotic recombination |
| Q42770281 | Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. |
| Q33849634 | Modeling variation in tumors in vivo |
| Q36056087 | Modulator of Apoptosis 1: A Highly Regulated RASSF1A-Interacting BH3-Like Protein |
| Q82521439 | Molecular Genetics of Colorectal Cancer |
| Q37004224 | Molecular Genetics of Colorectal Cancer: An Overview |
| Q37708015 | Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer. |
| Q78167044 | Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum |
| Q36329300 | Molecular classification and correlates in colorectal cancer |
| Q42480226 | Molecular cloning and functional analysis of the murine bax gene promoter |
| Q33919200 | Molecular detection of the G(-248)A BAX promoter nucleotide change in B cell chronic lymphocytic leukaemia |
| Q33670210 | Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects |
| Q41005399 | Molecular events after antisense inhibition of hMSH2 in a HeLa cell line |
| Q38762495 | Molecular evolution of colorectal cancer: from multistep carcinogenesis to the big bang |
| Q48164758 | Molecular genetic analysis of BAX and cyclin D1 genes in patients with malignant glioma |
| Q36501198 | Molecular mediators of cell death in multistep carcinogenesis: a path to targeted therapy |
| Q25257401 | Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis |
| Q37139174 | Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention |
| Q35069428 | Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan |
| Q36192733 | Molecular testing for microsatellite instability and its value in tumor characterization |
| Q35763450 | Molecular tumor clocks and dynamic phenotype |
| Q37253354 | MonoSeq Variant Caller Reveals Novel Mononucleotide Run Indel Mutations in Tumors with Defective DNA Mismatch Repair |
| Q77495447 | Mononucleotide repeat instability is infrequent in neuroblastoma |
| Q43087650 | Morphology of sporadic colorectal cancer with DNA replication errors |
| Q33751157 | Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells |
| Q38469522 | Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors |
| Q36308958 | Mutation analysis of APC gene in gastric cancer with microsatellite instability |
| Q55239937 | Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma. |
| Q35064299 | Mutation at intronic repeats of the ataxia-telangiectasia mutated (ATM) gene and ATM protein loss in primary gastric cancer with microsatellite instability |
| Q34635921 | Mutation frequencies at codon 248 of the p53 tumour suppressor gene are not increased in colon cancer cell lines with the RER+ phenotype |
| Q40762457 | Mutation frequency in coding and non-coding repeat sequences in mismatch repair deficient cells derived from normal human tissue |
| Q40909698 | Mutation of BAX occurs infrequently in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas. |
| Q35910074 | Mutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis |
| Q55260080 | Mutational analyses of multiple target genes in histologically heterogeneous gastric cancer with microsatellite instability. |
| Q47632068 | Mutational analysis of Noxa gene in human cancers |
| Q33576288 | Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability |
| Q53597447 | Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas. |
| Q28206338 | Mutational analysis of salvador gene in human carcinomas |
| Q37264027 | Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution |
| Q36417805 | Mutational targets in colorectal cancer cells with microsatellite instability. |
| Q74223885 | Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity |
| Q58408451 | Mutations de l’ADN mitochondrial et cancer colorectal |
| Q24290355 | Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling |
| Q34276988 | Mutations in apoptosis genes: a pathogenetic factor for human disease |
| Q52828898 | Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines. |
| Q40572643 | Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability |
| Q35360361 | Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum |
| Q37981834 | New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy |
| Q35150716 | Nonredundant role of Bax and Bak in Bid-mediated apoptosis |
| Q77891937 | Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium |
| Q24310705 | Noxa in colorectal cancer: a study on DNA, mRNA and protein expression |
| Q62805283 | Oestrogen receptors and microsatellite instability in colorectal carcinoma patients |
| Q28066110 | Opportunities for immunotherapy in microsatellite instable colorectal cancer |
| Q58493769 | Origin of Multiple Mutations in Human Cancers |
| Q40942248 | Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability |
| Q35747653 | PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers |
| Q24550772 | PUMA mediates the apoptotic response to p53 in colorectal cancer cells |
| Q55266327 | Parameter sensitivity analysis for a stochastic model of mitochondrial apoptosis pathway. |
| Q34975960 | Pathogenesis and clinical management of hereditary non-polyposis colorectal cancer |
| Q47967953 | Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes |
| Q37368316 | Pathological features of colorectal carcinomas in MYH-associated polyposis |
| Q36961965 | Pathophysiological Significance of Hepatic Apoptosis |
| Q41855884 | PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper |
| Q53421519 | Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds. |
| Q28295556 | Pro-apoptotic PUMA and anti-apoptotic phospho-BAD are highly expressed in colorectal carcinomas |
| Q35963747 | Proapoptotic BID is required for myeloid homeostasis and tumor suppression |
| Q74133434 | Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas |
| Q36490192 | Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities |
| Q38293314 | Proficient mismatch repair protein expression in Hodgkin and Reed Sternberg cells |
| Q74372251 | Prognostic relevance of hMLH1, hMSH2, and BAX protein expression in endometrial carcinoma |
| Q90339349 | Prognostic value and susceptibility of BAX rs4645878 polymorphism in cancer: A systematic review and meta-analysis |
| Q34634857 | Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. |
| Q37245289 | Promoter methylation in the genesis of gastrointestinal cancer |
| Q35871679 | RETRACTED: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function |
| Q36963387 | Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway |
| Q35878431 | Rapamycin rescues ABT-737 efficacy in small cell lung cancer |
| Q54647238 | Reassessing the TARBP2 mutation rate in hereditary nonpolyposis colorectal cancer. |
| Q51347935 | Reduced risk of apoptosis: mechanisms of stress responses. |
| Q57092286 | Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis |
| Q41563049 | Regional Bias of Intratumoral Genetic Heterogeneity of Apoptosis-Related Genes BAX, APAF1, and FLASH in Colon Cancers with High Microsatellite Instability |
| Q34245385 | Regulation and function of the p53 tumor suppressor protein |
| Q42775424 | Regulation of CD30 antigen expression and its potential significance for human disease |
| Q39461469 | Regulation of cell death in cancer-possible implications for immunotherapy |
| Q53998721 | Relationship between grade of microsatellite instability and target genes of mismatch repair pathways in sporadic colorectal carcinoma. |
| Q78123204 | Relationship between intratumor histological heterogeneity and genetic abnormalities in gastric carcinoma with microsatellite instability |
| Q34390964 | Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. |
| Q43938032 | Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status |
| Q52000126 | Resolving the evolutionary paradox of genetic instability: a cost-benefit analysis of DNA repair in changing environments. |
| Q24806345 | Role of APC and DNA mismatch repair genes in the development of colorectal cancers |
| Q38108758 | Role of BAX for outcome prediction in gastrointestinal malignancies. |
| Q31523620 | Role of BAX in the apoptotic response to anticancer agents |
| Q77733988 | Role of BAX mutations in mismatch repair-deficient colorectal carcinogenesis |
| Q34733047 | Role of Bcl-2 family of proteins in malignancy |
| Q37331465 | Role of apoptosis in colon cancer biology, therapy, and prevention |
| Q26865637 | Role of apoptosis in disease |
| Q91584504 | Role of apoptosis repressor with caspase recruitment domain (ARC) in cancer |
| Q44399860 | Role of polymorphisms in BCL-2 and BAX genes in modulating the risk of developing non-Hodgkin lymphoma |
| Q40020072 | Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. |
| Q42003162 | S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis |
| Q27824786 | SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer |
| Q35438561 | Screening for microsatellite instability target genes in colorectal cancers. |
| Q52831040 | Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers. |
| Q48939509 | Second primary glioblastoma |
| Q24643420 | SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology |
| Q35207960 | Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies |
| Q78068271 | Shortened microsatellite d(CA)21 sequence down-regulates promoter activity of matrix metalloproteinase 9 gene |
| Q39737975 | Signatures of mutation and selection in the cancer genome |
| Q33846180 | Significance of multiple mutations in cancer |
| Q31041738 | Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarray |
| Q24297546 | Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis |
| Q61449459 | Somatic alterations of the androgen receptor CAG repeat in human colon cancer delineate a novel mutation pathway independent of microsatellite instability |
| Q24803238 | Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype |
| Q53414620 | Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. |
| Q73035204 | Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability |
| Q30423124 | Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types |
| Q86114026 | Somatic mutations of amino acid metabolism-related genes in gastric and colorectal cancers and their regional heterogeneity--a short report |
| Q37483818 | Subchronic perfluorooctanesulfonate (PFOS) exposure induces elevated mutant frequency in an in vivo λ transgenic medaka mutation assay |
| Q53410171 | Synchronous multiple primary gastrointestinal cancer exhibits frequent microsatellite instability. |
| Q42215995 | Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines. |
| Q53398388 | Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cells. |
| Q24288715 | TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers |
| Q46179627 | TP53 mutations in canine brain tumors |
| Q39753656 | TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. |
| Q24309591 | TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process |
| Q92632099 | Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles |
| Q26765447 | Targeting Cell Survival Proteins for Cancer Cell Death |
| Q39248620 | Targeting FLIP and Mcl-1 using a combination of aspirin and sorafenib sensitizes colon cancer cells to TRAIL. |
| Q38881119 | Targeting Programmed Cell Death Using Small-Molecule Compounds to Improve Potential Cancer Therapy |
| Q90590454 | Targeting apoptosis in cancer therapy |
| Q42175008 | Targeting apoptosis signaling pathways for anticancer therapy |
| Q34791120 | Targeting death and decoy receptors of the tumour-necrosis factor superfamily |
| Q26866936 | Targeting the Bcl-2 family for cancer therapy |
| Q37862534 | Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis |
| Q36397223 | Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer |
| Q36067778 | The BCL-2 protein family, BH3-mimetics and cancer therapy |
| Q24620437 | The Bcl-2 apoptotic switch in cancer development and therapy |
| Q35591695 | The Bcl-2 family: roles in cell survival and oncogenesis. |
| Q38268329 | The Bcl-2 family: structures, interactions and targets for drug discovery |
| Q29614982 | The Bcl2 family: regulators of the cellular life-or-death switch |
| Q35448964 | The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck |
| Q34241295 | The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors |
| Q28594399 | The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation |
| Q34265917 | The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. |
| Q73810807 | The apoptotic regulatory gene, BCL10, is mutated in sporadic mismatch repair deficient colorectal cancers |
| Q33717586 | The apoptotic response in HCT116 BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein |
| Q33762979 | The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside |
| Q28115905 | The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice |
| Q33771774 | The cellular response to p53: the decision between life and death |
| Q35753518 | The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes |
| Q35541834 | The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak |
| Q34263814 | The contribution of endogenous sources of DNA damage to the multiple mutations in cancer |
| Q40078553 | The death of human cancer cells following photodynamic therapy: apoptosis competence is necessary for Bcl-2 protection but not for induction of autophagy |
| Q37959968 | The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance |
| Q39102953 | The effects of silencing of PI3K p85α on 5-FU-induced colorectal cancer cells apoptosis |
| Q35083049 | The essential role of evasion from cell death in cancer |
| Q34989790 | The genetic pathogenesis of colorectal cancer |
| Q34180336 | The genetics and genomics of cancer |
| Q24814928 | The immunogenicity of colorectal cancers with high-degree microsatellite instability |
| Q37412188 | The landscape of microsatellite instability in colorectal and endometrial cancer genomes |
| Q29547648 | The landscape of somatic copy-number alteration across human cancers |
| Q34533276 | The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome |
| Q27012559 | The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death |
| Q34027887 | The molecular genetics of colorectal cancer |
| Q74481910 | The mutation rate and cancer |
| Q41489275 | The p53-Bcl-2 connection |
| Q36558006 | The permeability transition pore complex in cancer cell death |
| Q44539646 | The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells |
| Q38448770 | The replication error phenotype is associated with the development of distant metastases in hormonally treated patients with breast carcinoma |
| Q33811934 | The role of DNA mismatch repair in cisplatin mutagenicity |
| Q36615234 | The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers |
| Q35745852 | The role of microsatellite instability in gastric low- and high-grade lymphoma development |
| Q41659044 | The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy |
| Q28487756 | The sensitivity of diffuse large B-cell lymphoma cell lines to histone deacetylase inhibitor-induced apoptosis is modulated by BCL-2 family protein activity |
| Q34108917 | The use of FRET imaging microscopy to detect protein-protein interactions and protein conformational changes in vivo |
| Q37313219 | Therapeutic modulation of apoptosis: targeting the BCL-2 family at the interface of the mitochondrial membrane |
| Q73855680 | There is no increase in frequency of somatic mutations in metastases compared with primary colorectal carcinomas with microsatellite instability |
| Q38715430 | Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies |
| Q36296721 | Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide |
| Q44402973 | Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: β2‐microglobulin inactivation in MSI‐positive tumors and LMP7/TAP2 downregulation in MSI‐negative tumors |
| Q35065708 | Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression |
| Q50538007 | Transforming growth factor β type II receptor as a marker in diffuse large B cell lymphoma. |
| Q90974923 | Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon |
| Q33834246 | Tumor cells utilize multiple pathways to down-modulate apoptosis. Lessons from a mouse model of islet cell carcinogenesis |
| Q26866179 | Tumor immunotherapy: lessons from autoimmunity |
| Q33846232 | Tumor progression and metastasis |
| Q43903493 | Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. |
| Q34985439 | Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations. |
| Q40827748 | Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro |
| Q36216663 | Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability |
| Q57977998 | Tumors with microsatellite instability: many mutations, targets and paradoxes |
| Q35565700 | Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status |
| Q28508905 | Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair |
| Q85075327 | Turning up the heat on colorectal cancer |
| Q92322223 | Uncovering missed indels by leveraging unmapped reads |
| Q40579532 | Unique characteristics of rectal carcinoma cell lines derived from invasive carcinomas in ulcerative colitis patients |
| Q24657391 | Unregulated smooth-muscle myosin in human intestinal neoplasia |
| Q39189499 | Upregulation of DR5 receptor by the diaminothiazole DAT1 [4-amino-5-benzoyl-2-(4-methoxy phenyl amino) thiazole] triggers an independent extrinsic pathway of apoptosis in colon cancer cells with compromised pro and antiapoptotic proteins |
| Q50335614 | Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability |
| Q38327592 | Villin expression is frequently lost in poorly differentiated colon cancer. |
| Q36254857 | Viruses with deletions in antiapoptotic genes as potential oncolytic agents. |
| Q44100502 | Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgene |
| Q38352979 | XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway |
| Q74825051 | Yeast ARMs (DNA at-risk motifs) can reveal sources of genome instability |
| Q53414161 | [Explanation of enigmas of the Lynch syndrome thanks to a new carcinogenesis model characterized by an unorthodox initiation process]. |
| Q34008781 | p38α MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance. |
| Q45886663 | p53 Gene therapy for lung cancer |
| Q44588662 | p53 alterations and their relationship to SDHD mutations in parasympathetic paragangliomas |
| Q29617084 | p53 and metabolism |
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