Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer

scientific article

Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID1734424
P698PubMed publication ID10507723

P50authorGareth EvansQ29642643
Cecilia BrassettQ48504849
P2093author name stringE R Maher
R D Kolodner
L Verma
M F Kane
J Schmeits
P2860cites workUbiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesisQ22122362
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6Q24323176
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutationsQ27935158
Mutation of a mutL homolog in hereditary colon cancerQ28114939
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancerQ28253384
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancerQ28256988
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancerQ28257360
Biochemistry and genetics of eukaryotic mismatch repairQ28282377
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancerQ28289377
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor CellsQ28292781
Mutations of GTBP in genetically unstable cellsQ28292802
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repairQ28508905
Mouse models for hereditary nonpolyposis colorectal cancerQ28585761
Mutation in the mismatch repair gene Msh6 causes cancer susceptibilityQ28592583
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repairQ29615027
Microsatellite instability in cancer of the proximal colonQ29620692
Microsatellite instability in early onset and familial colorectal cancer.Q33678081
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
Functional overlap in mismatch repair by human MSH3 and MSH6.Q34603929
Mutator phenotypes in human colorectal carcinoma cell linesQ35568305
Mechanisms and biological effects of mismatch repairQ37041860
Genetic instability occurs in the majority of young patients with colorectal cancerQ38297232
Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancerQ38328724
Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genesQ40022200
Characterization of distinct human endometrial carcinoma cell lines deficient in mismatch repair that originated from a single tumorQ41005472
Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancerQ42005199
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeastQ42427955
Clues to the pathogenesis of familial colorectal cancerQ42622043
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformationQ46049171
Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindredQ48044118
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancerQ48084125
Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.Q50893078
Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression.Q53439660
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patientsQ57570041
Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal CancerQ61946741
The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)Q62978412
Colorectal cancer screeningQ68194974
Molecular analysis of mutations in mutator colorectal carcinoma cell linesQ70972736
Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genesQ71733947
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
microsatelliteQ265193
colorectal carcinomaQ25493920
P304page(s)678-682
P577publication date1999-09-01
P1433published inJournal of Medical GeneticsQ14640281
P1476titleMononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer
P478volume36

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cites work (P2860)
Q48252170Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors
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Q36611645MSH6 germline mutations in early-onset colorectal cancer patients without family history of the disease
Q49959979MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia
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Q90749821Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal Cancer
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