The role of DNA exonucleases in protecting genome stability and their impact on ageing.

scientific article

The role of DNA exonucleases in protecting genome stability and their impact on ageing. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S11357-011-9306-5
P932PMC publication ID3528374
P698PubMed publication ID21948156

P50authorLynne S CoxQ47503394
P2093author name stringPenelope A Mason
P2860cites workStructure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activityQ22003979
Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complexQ22008596
Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidanceQ22009967
Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleasesQ22010206
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD proteinQ22010212
The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesQ22010967
Eukaryotic DNA PolymerasesQ22065416
Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonucleaseQ22253323
Ku complex interacts with and stimulates the Werner proteinQ22253994
Characterization of the human and mouse WRN 3'-->5' exonucleaseQ22254412
Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genesQ24291021
Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteinsQ24291054
p53 Modulates the exonuclease activity of Werner syndrome proteinQ24291371
Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonucleaseQ47070640
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.Q51618454
Caenorhabditis elegans DNA-2 helicase/endonuclease plays a vital role in maintaining genome stability, morphogenesis, and life span.Q51886397
Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injuryQ57537758
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formationQ60284598
Two Pathways for Base Excision Repair in Mammalian CellsQ60702220
p53 Protein exhibits 3'-to-5' exonuclease activityQ71170481
Fanconi anemiaQ72146633
Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease IIIQ73384174
A 3'-5' exonuclease in human leukemia cells: implications for resistance to 1-beta -D-arabinofuranosylcytosine and 9-beta -D-arabinofuranosyl-2-fluoroadenine 5'-monophosphateQ73838487
Defective DNA polymerase-delta proofreading causes cancer susceptibility in miceQ73954766
The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunitQ74371876
Biochemical characterization of the DNA substrate specificity of Werner syndrome helicaseQ77948758
A nuclear 3'-5' exonuclease proofreads for the exonuclease-deficient DNA polymerase alphaQ78804406
Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase deltaQ82346662
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activityQ24291787
Human exonuclease I is required for 5' and 3' mismatch repairQ24292224
An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNAQ24292267
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repairQ24293244
Premature ageing in mice expressing defective mitochondrial DNA polymeraseQ24294365
Feedback between p21 and reactive oxygen production is necessary for cell senescenceQ24299631
The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CADQ24301815
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesQ24304488
Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1Q24305550
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substratesQ24308828
Asymmetry of DNA replication fork progression in Werner's syndromeQ24311409
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaksQ24311761
p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosisQ24312817
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediatesQ24312975
A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonucleaseQ24314103
Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2Q24314329
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleasesQ24314357
Human Dna2 is a nuclear and mitochondrial DNA maintenance proteinQ24316108
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseasesQ24317166
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processingQ24318651
XPG endonuclease makes the 3' incision in human DNA nucleotide excision repairQ24320768
The characterization of a mammalian DNA structure-specific endonucleaseQ24336672
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2Q24337575
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agentsQ24337605
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repairQ24337655
Circulating mitochondrial DAMPs cause inflammatory responses to injuryQ29614470
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteinsQ29615270
Positional cloning of the Werner's syndrome geneQ29618393
Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator miceQ30498491
DNA replication: partners in the Okazaki two-stepQ30755185
The protein components and mechanism of eukaryotic Okazaki fragment maturationQ31034204
On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processingQ31038690
Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domainsQ33234879
Tissue specific mutagenic and carcinogenic responses in NER defective mouse modelsQ33246534
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional miceQ33297433
Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repairQ33402478
FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cellsQ33670045
The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.Q33884556
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell agingQ33891793
ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activationQ33940379
Delineation of WRN helicase function with EXO1 in the replicational stress responseQ33945750
The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiaeQ33957467
Stability of the human fragile X (CGG)(n) triplet repeat array in Saccharomyces cerevisiae deficient in aspects of DNA metabolismQ33958980
Novel function of Rad27 (FEN-1) in restricting short-sequence recombinationQ33967784
DNA damage-dependent nuclear dynamics of the Mre11 complexQ33975168
An mre11 mutation that promotes telomere recombination and an efficient bypass of senescenceQ34007895
Evidence for extrinsic exonucleolytic proofreading.Q34010452
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progressionQ34098053
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link RepairQ34128701
Homologous recombination resolution defect in werner syndromeQ34150355
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forksQ34166526
Identification and characterization of the human mus81-eme1 endonucleaseQ34193657
Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiationQ34302249
Hereditary non-polyposis colorectal cancer and the role of hPMS2 and hEXO1 mutationsQ34544905
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilationQ34587260
The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA.Q34602847
A DNA polymerase epsilon mutant that specifically causes +1 frameshift mutations within homonucleotide runs in yeastQ34610131
Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolismQ34613942
The Mre11 complex: at the crossroads of dna repair and checkpoint signallingQ34623788
Drosophila and human RecQ5 exist in different isoforms generated by alternative splicingQ24548864
Human xeroderma pigmentosum group G gene encodes a DNA endonucleaseQ24562951
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient miceQ24598687
DNA mismatch repair: molecular mechanism, cancer, and ageingQ24647002
Rapamycin fed late in life extends lifespan in genetically heterogeneous miceQ24647805
Caloric restriction delays disease onset and mortality in rhesus monkeysQ24655994
Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2Q24677826
A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in ArabidopsisQ24810688
trt-1 is the Caenorhabditis elegans catalytic subunit of telomeraseQ25257224
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase betaQ25257806
Structure of the replicating complex of a pol alpha family DNA polymeraseQ27632340
Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulationQ27655485
Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint ComplexQ27656003
Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 SuperfamilyQ27667524
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease FamilyQ27667527
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structureQ27729885
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Analysis of the role of the NUC1 endo/exonuclease in yeast mitochondrial DNA recombinationQ27930773
Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombinationQ27930776
Mutations in DNA replication genes reduce yeast life spanQ27934618
Endonuclease G regulates budding yeast life and deathQ27934853
Purification and properties of the major nuclease from mitochondria of Saccharomyces cerevisiae.Q27936136
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenanceQ27937328
Identification of Holliday junction resolvases from humans and yeastQ27937498
Polymerase epsilon is required to maintain replicative senescenceQ27938473
Evidence for a role of FEN1 in maintaining mitochondrial DNA integrityQ27939094
EXOG, a novel paralog of Endonuclease G in higher eukaryotesQ28114799
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorderQ28115238
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2Q28116237
Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damageQ28138254
Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiaeQ28140402
Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosisQ28141886
The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome proteinQ28155868
Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNAQ28182710
Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC formsQ28190757
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51Q28202527
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathwayQ28203777
Endonuclease G is an apoptotic DNase when released from mitochondriaQ28206238
Human Mus81-associated endonuclease cleaves Holliday junctions in vitroQ28210371
Mammalian mitochondrial endonuclease G. Digestion of R-loops and localization in intermembrane spaceQ28215595
Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairsQ28239438
Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repairQ28240258
DNA repairQ28247467
The biologic clock: the mitochondria?Q28249363
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell deathQ28250070
Reconstitution of complete SV40 DNA replication with purified replication factorsQ28251397
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locusQ28252435
The Werner syndrome protein has separable recombination and survival functionsQ28256444
The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things togetherQ28274236
Linking functional decline of telomeres, mitochondria and stem cells during ageingQ28277689
The Werner syndrome protein at the crossroads of DNA repair and apoptosisQ28279631
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axisQ28280037
Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombinationQ28289308
The high fidelity and unique error signature of human DNA polymerase epsilonQ28297227
Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and humanQ28302765
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator miceQ28474793
Do mtDNA deletions drive premature aging in mtDNA mutator mice?Q28742556
Mammalian mitochondrial endonuclease GQ29300273
Blinded by the Light: The Growing Complexity of p53Q29547590
Displacement of DNA-PKcs from DNA ends by the Werner syndrome proteinQ39688137
Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damageQ39698684
Mitofusin 2 inhibits mitochondrial antiviral signalingQ39811050
Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory diseaseQ39851605
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophyQ40101085
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repairQ40135858
Genetic association of single nucleotide polymorphisms in endonuclease G-like 1 gene with type 2 diabetes in a Japanese population.Q40148417
Correction of proliferation and drug sensitivity defects in the progeroid Werner's Syndrome by Holliday junction resolution.Q40155557
Mitochondrial role in cell agingQ40300244
Exogenous expression of exonuclease domain-deleted WRN interferes with the repair of radiation-induced DNA damagesQ40333594
Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.Q40422537
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.Q40481955
Structural basis for recruitment of human flap endonuclease 1 to PCNAQ41106952
Fanconi's anemia and malignanciesQ41189229
Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethalityQ41283109
Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1.Q41656068
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repairQ41914934
Biochemical characterization of an exonuclease from Arabidopsis thaliana reveals similarities to the DNA exonuclease of the human Werner syndrome proteinQ42606844
Hydrolysis of 3'-terminal mispairs in vitro by the 3'----5' exonuclease of DNA polymerase delta permits subsequent extension by DNA polymerase alphaQ42632067
Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblastsQ42989281
The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestQ43189875
Live fast, die young: new lessons in mammalian longevity.Q43282002
Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forksQ44041879
Biochemical characterization of the WRN-FEN-1 functional interactionQ44160517
The exonuclease activity of human apurinic/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G.Q44353890
Structural and functional characterization of mitochondrial EndoG, a sugar non-specific nuclease which plays an important role during apoptosisQ44831847
Dna2 helicase/nuclease causes replicative fork stalling and double-strand breaks in the ribosomal DNA of Saccharomyces cerevisiaeQ46123466
DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonucleaseQ46290652
Evidence that yeast SGS1, DNA2, SRS2, and FOB1 interact to maintain rDNA stabilityQ46510173
Fen1 mutations result in autoimmunity, chronic inflammation and cancersQ46593630
A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks.Q46845186
Endonuclease G: a role for the enzyme in recombination and cellular proliferationQ34694745
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune diseaseQ34719398
Activation and regulation of ATM kinase activity in response to DNA double-strand breaksQ34722727
Identification of germ plasm-associated transcripts by microarray analysis of Xenopus vegetal cortex RNA.Q34726011
DNA structure dependent checkpoints as regulators of DNA repairQ35046592
Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.Q35085004
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancerQ35085696
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndromeQ35159006
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repairQ35618148
Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditisQ35663520
Extension of base mispairs by Taq DNA polymerase: implications for single nucleotide discrimination in PCRQ35927120
Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeresQ35946397
Sequence and expression of NUC1, the gene encoding the mitochondrial nuclease in Saccharomyces cerevisiaeQ36000714
Cockayne's syndrome: a case report. Literature review.Q36464213
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitroQ36568265
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humansQ36658296
Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrityQ36691491
Evolving views of DNA replication (in)fidelityQ36772885
DNA replication and transcription in mammalian mitochondriaQ36780113
New insights into the combined Cockayne/xeroderma pigmentosum complex: human XPG protein can function in transcription factor stabilityQ36805145
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondriaQ36845992
The premature ageing syndrome protein, WRN, is a 3'-->5' exonucleaseQ37083237
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activationQ37104813
Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant miceQ37320331
Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stabilityQ37424442
Cytoplasmic functions of the tumour suppressor p53.Q37466228
Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?Q37485742
DNA2 resolves expanding flap in mitochondrial base excision repairQ37668905
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1.Q37695856
Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease 1 in complex with a nicked DNA product: use of a DPCS kit for efficient protein-DNA complex crystallizationQ38271895
A conserved 5' to 3' exonuclease activity in the yeast and human nucleotide excision repair proteins RAD2 and XPG.Q38301223
DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathwaysQ38303463
Fidelity of eucaryotic DNA polymerase delta holoenzyme from Schizosaccharomyces pombeQ38313569
Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1.Q38332703
Properties of and substrate determinants for the exonuclease activity of human apurinic endonuclease Ape1.Q38352576
P433issue6
P921main subjectgenome stabilityQ98655700
P304page(s)1317-1340
P577publication date2011-09-23
P1433published inAgeQ4691832
P1476titleThe role of DNA exonucleases in protecting genome stability and their impact on ageing
P478volume34

Reverse relations

cites work (P2860)
Q41877420A fluorescence-based exonuclease assay to characterize DmWRNexo, orthologue of human progeroid WRN exonuclease, and its application to other nucleases
Q96434565Artificial selection reveals the role of transcriptional constraints in the maintenance of life history variation
Q38485116Degradation systems in heart failure
Q41144456Differential expression profile analysis of DNA damage repair genes in CD133+/CD133- colorectal cancer cells
Q56637826Fidelity of DNA replication—a matter of proofreading
Q34031638Free radicals and antioxidants: updating a personal view
Q34052630Implications of the colonic deposition of free hemoglobin-α chain: a previously unknown tissue by-product in inflammatory bowel disease
Q38870074POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies
Q34619374The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers
Q24618841The antioxidant paradox: less paradoxical now?
Q55322083The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair.

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